Results 71 to 80 of about 152,676 (293)

First order optimality condition for constrained set-valued optimization [PDF]

A constrained optimization problem with set-valued data is considered. Different kind of solutions are defined for such a problem. We recall weak minimizer, efficient minimizer and proper minimizer.
Rocca Matteo, Ginchev Ivan, Crespi Giovanni P.   +2 more
core  

Sharp Lagrange multipliers for set-valued optimization problems

, 2022
In this paper, we give a comparison among some notions of weak sharp minima introduced in Amahroq et al. [Le matematiche J. 73 (2018) 99–114], Durea and Strugariu [Nonlinear Anal. 73 (2010) 2148–2157] and Zhu et al. [Set-Valued Var. Anal.
Abdessamad Oussarhan, Tijani Amahroq
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

First order optimality conditions in set-valued optimization [PDF]

A a set-valued optimization problem minC F(x), x 2 X0, is considered, where X0 X, X and Y are Banach spaces, F : X0 Y is a set-valued function and C Y is a closed cone.
Rocca Matteo, Ginchev Ivan, Crespi Giovanni P.   +2 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Painlevé-Kuratowski convergence for set optimization solutions using improvement sets

Applied Mathematics in Science and Engineering
This paper investigates the Painlevé-Kuratowski convergence of solution sets in set optimization problems under perturbations. By introducing the notion of [Formula: see text]-[Formula: see text]-Strictly quasiconvexity for set-valued mappings, we ...
Taiyong Li, Manli Yang
doaj   +1 more source

Coderivatives and Aubin property of efficient point and efficient solution set-valued maps in parametric vector optimization

Journal of Inequalities and Applications, 2020
The aim of this paper is computing the coderivatives of efficient point and efficient solution set-valued maps in a parametric vector optimization problem.
Xiaowei Xue
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Higher-Order Optimality Conditions in Set-Valued Optimization with Respect to General Preference Mappings. [PDF]

Set Valued Var Anal, 2022
Michalak A, Studniarski M.
europepmc   +1 more source