Results 111 to 120 of about 925,039 (306)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Species Distribution and Forest Type Mapping in Mexico

, 2009
The study analyzed the potential of multi-temporal satellite remote sensing data (Terra-MODIS) for phenological studies in Mexico. Within two conceptually and methodologically independent approaches, we analyzed vegetation index data to continuously ...
Cord, Anna, Schmidt, Michael, Dech, Stefan, Anna Cord, Colditz, Rene, Rene R. Colditz, Stefan Dech, Michael Schmidt   +7 more
core   +1 more source

Fractional Set Cover in the Streaming Model [PDF]

, 2017
We study the Fractional Set Cover problem in the streaming model. That is, we consider the relaxation of the set cover problem over a universe of n elements and a collection of m sets, where each set can be picked fractionally, with a value in [0,1].
Indyk, Piotr, Vakilian, Ali, Ullman, Jonathan, Mahabadi, Sepideh, Rubinfeld, Ronitt, Yodpinyanee, Anak   +5 more
core   +1 more source

Semi-Streaming Set Cover

ACM Transactions on Algorithms, 2016
This article studies the set cover problem under the semi-streaming model. The underlying set system is formalized in terms of a hypergraph G = ( V , E ) whose edges arrive one by one, and the goal is to construct an edge cover F ⊆ E
Yuval Emek, Adi Rosén
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Glubran- 2 Acrylic Glue for Percutaneous Embolization of Intramuscular Vascular Malformations of Lower Limbs: Preliminary Experience

, 2020
Aims: Vascular anomalies (VA) represent a heterogeneous and rare group of pathologies. Ethanol is considered the gold standard in endovascular embolization procedures, but its use exposes to the risk of major complications. Glubran-2 is a new glue agent,
Ruggiero, Federica, Compagna, Rita, Mattassi, Raul, Amato, Bruno, Stillo, Francesco   +4 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Partially polynomial kernels for set cover and test cover

, 2016
An instance of the (n-k)-Set Cover or the (n-k)-Test Cover problems is of the form (U, S, k), where U is a set with n elements, S ⊆ 2U with |S| = m, and k is the parameter. The instance is a Yes-instance of (n - k)-Set Cover if and only if there exists S\
Francis, Mathew C., Basavaraju, Manu, Ramanujan, M. S., Saurabh, Saket   +3 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The 0-1 inverse maximum stable set problem [PDF]

Given an instance of a weighted combinatorial optimization problem and its feasible solution, the usual inverse problem is to modify as little as possible (with respect to a fixed norm) the given weight system to make the giiven feasible solution optimal.
Yerim Chung, Marc Demange
core