Results 121 to 130 of about 925,039 (306)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Comparing regional differentiation of land cover changes in natural and administrative regions of the Czech Republic using multivariate statistics [PDF]
The detection and evaluations of land cover changes represent the major task for landscape transformation studies in post-communistic countries. The results of such evaluation are, however, highly influenced by spatial delimitation of monitored units as ...
JiřÃÂ Anděl +4 more
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
On the differential approximation of MIN SET COVER
, 2005 We present in this paper differential approximation results for MIN SET COVER and MIN WEIGHTED SET COVER. We first show that the differential approximation ratio of the natural greedy algorithm for MIN SET COVER is bounded below by 1.365/Δ and above by 4/
Monnot, Jérôme +3 more
core +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Discovery of the Major Mechanism of Global Warming and Climate Change
, 2012 Statistical analysis of the number of destructive earthquakes versus global temperature and greenhouse gases revealed very significant correlations. The motion of the North Pole, deduced from the geomagnetic polar shift data, is highly correlated with ...
Rivera, Paul C., Khan, Tariq Masood Ali
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Approximating the dense set-cover problem
, 2004 We study the set-cover problem, i.e. given a collection C of subsets of a finite set U, find a minimum size subset C′⊆C such that every element in U belongs to at least one member of C.
Kehat, Zehavit, Bar-Yehuda, Reuven
core +1 more source