Results 131 to 140 of about 1,084,937 (314)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Comparing Rough Set Theory with Multiple Regression Analysis as Automated Valuation Methodologies [PDF]

open access: yes
This paper focuses on the problem of applying rough set theory to mass appraisal. This methodology was first introduced by a Polish mathematician, and has been applied recently as an automated valuation methodology by the author.
Maurizio d’Amato
core  

Initial self-embeddings of models of set theory [PDF]

open access: yes
This article has been published in a revised form in [Journal of Symbolic Logic] [http://doi.org/10.1017/jsl.2021.62]. This version is published under a Creative Commons CC-BY-NC-ND licence. No commercial re-distribution or re-use allowed.
McKenzie, Zachiri, Enayat, Ali
core   +1 more source

Of ends and means: Development policy assessment with human development and multiple causality

open access: yesDesarrollo y Sociedad, 2019
Policy assessment often involves the study of outcomes and their causes. Development policy analyses have conventionally used an economistic perspective with a focus mainly on pecuniary indicators and the search for the one model of best fit. However, i)
Pablo Garcés Velástegui
doaj   +1 more source

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