Results 41 to 50 of about 1,431,450 (340)

Research on the Vibration Fatigue Characteristics of Ancient Building Wood Materials

Buildings
In this study, we selected ancient building timber as the research object. A series of static load tests were conducted to analyze the different performances of timber under tensile and compressive loads.
Chunyu Qian, Mingze Li, Hongjian Liao, Chenhe Zhang, Hangzhou Li   +4 more
doaj   +1 more source

Early Settlement in European Merger Control [PDF]

, 2016
We analyse the determinants of early settlement between merging parties and the European Commission over remedies that remove concerns of anticompetitive effects.
Aktas, Ashenfelter, Ausubel, Baker, Bebchuk, Bergman, Bougette, Bourjade, Coate, Coate, Coate, Coate, Cooter, Cramton, Davies, Davies, Davies, Dougherty, Duso, Fenn, Fenn, Fenn, Fernández, Fournier, Fournier, Friedman, Fudenberg, Grossman, Ivaldi, Kennan, Kessler, Kessler, Kouliavtsev, Kühn, Lindsay, Lyons, Ormosi, Perloff, Priest, Reinganum, Sobel, Spier, Spier, Ven, Waldfogel   +44 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The Role of the Judge in Non-Class Settlement [PDF]

, 2013
This commentary argues that judges lack the authority, as a general matter, to approve or reject non-class settlements. While judges overseeing mass litigation can set the stage for settlement by instituting phased discovery, scheduling bellwether trials,
Erichson, Howard M.
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Satisfaction of female-headed households on state-led resettlement housing in Kigali: A gender intersectionality lens

Cogent Social Sciences
Female-headed households (FHHs) constitute a heterogeneous social group with diverse resettlement housing needs, expectations, and aspirations. This study intends to expand knowledge on resettlement housing schemes using a gender lens.
Tharcille Dukuzemariya, Wilbard J. Kombe, Tatu Mtwangi-Limbumba   +2 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Conflicts Between Dispute Settlement Mechanisms in Regional Trade Agreements and the WTO — What Should WTO Do? [PDF]

, 2009
It was a tremendous pleasure to participate in a symposium that honored one of the giants of the World Trade Organization\u27s (WTO) Appellate Body—Professor Yasuhei Taniguchi.
Hillman, Jennifer A.
core   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Parametric Analysis Towards the Design of Micro-Scale Wind Turbines: A Machine Learning Approach

Applied System Innovation
Wind turbine design is an iterative process. Many aspects are considered when designing a wind turbine, including aerodynamic and power performance, structural loads and behavior, and control techniques.
Raneem Mansour, Seifelden Osama, Hazem Ahmed, Mohamed Nasser, Norhan Mahmoud, Amira Elkodama, Amr Ismaiel   +6 more
doaj   +1 more source