Results 71 to 80 of about 1,431,450 (340)

Clothes as a source of creativity in interior design

open access: yesJournal of Architecture, Art & Humanistic Science, 2019
The imagination of the artist “designer” plays an important role in the aesthetic creativity of all applied arts; regardless of their types and methods. Without this creativity, the designer can’t express their ideas by using plastic raw material/s which
Nihal Afify, Wael Kamel El Sayed
doaj   +1 more source

Dynamic effect of high speed railway traffic loads on the ballast track settlement [PDF]

open access: yes, 2011
The traditional ballast track structures are still being used in high speed railways lines with success, however technical problems or performance features have led to non-ballast track solution in some cases.
Gabaldón Castillo, Felipe   +2 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Influence of Mortar Rheology on Aggregate Settlement [PDF]

open access: yes, 2000
The influence of the rheology of fresh concrete on the settlement of aggregate is examined. Fresh concrete exhibits a yield stress that, under certain conditions, prevents the settlement of coarse aggregate, although its density is larger than that of ...
Gadala-Maria, Francis   +4 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Degradation of Poliovirus Sabin 2 Genome After Electron Beam Irradiation

open access: yesVaccines
Objectives: Most antiviral vaccines are created by inactivating the virus using chemical methods. The inactivation and production of viral vaccine preparations after the irradiation of viruses with accelerated electrons has a number of significant ...
Dmitry D. Zhdanov   +12 more
doaj   +1 more source

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