Results 81 to 90 of about 94,352 (268)

A Study on the Perceptual Differences in Street Space in Historic and Cultural Districts from the Host–Guest Shared Perspective: A Case Study of the Sajinqiao Area in Xi’an, China

Buildings
In historic and cultural districts characterized by the coexistence of residential and commercial functions, street spaces play a pivotal role in shaping urban cultural continuity and local identity.
Lu Zhang, Dingqing Zhang, Zitong Tang, Yingtao Qi, Mengying Wang   +4 more
doaj   +1 more source

Agro-ecological monitoring of the territory of the Chelyabinsk agriculture research institute [PDF]

BIO Web of Conferences
Agroecological monitoring of lands is an important tool in regulating the development of unfavorable processes of lands suitable for agricultural use. It is a component of land use forecasting. The article is devoted to the organization of agroecological
Ottinger D.M., Gusev A.S., Inysheva V.A., Lopukhov P.M., Anisimov Yu.B.   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Foliar Application of Strontium for the Identification of Roots from Specific Wheat Plants

Agriculture
In the field of crop research, the study of roots involves many challenges, particularly the lack of effective methods for identifying crop roots. To deal with this problem, this study proposes a solution strategy: in applying strontium to crop leaves ...
Senlin Fu, Di Liu, Yanjiao Tian, Xiaofeng Xu, Zhaoyong Shi   +4 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Modelling the Impact of Blockchain Technology Barriers on Construction Procurement Systems in Nigeria

Advances in Civil Engineering
Blockchain is a decentralised system based on cryptographic procedures and smart contracts that records every transaction and shares it with all parties involved, thereby handling issues of delays and trust.
David Ojimaojo Ebiloma, Opeoluwa Akinradewo, Clinton Ohis Aigbavboa, Babatunde Fatai Ogunbayo   +3 more
doaj   +1 more source

‘Keep learning, keep trying’: exploring food and cultural experiences and supports of Inuvialuit youth in the Inuvialuit Settlement Region

Global Public Health
Country food (CF) and subsistence harvesting are crucial for Inuvialuit of the Inuvialuit Settlement Region, contributing to food security, wellbeing and cultural continuity. However, youth face barriers to participating in these activities, with a shift
Maria Ramirez Prieto, Sonja Ostertag, Kanelsa Noksana, Shayla Arey, Denise Wolki, Susie Memogana, Celina Wolki, Aimee Yurris, Kelly Skinner   +8 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source