Results 81 to 90 of about 449,899 (310)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Settlement of Macoma balthica larvae in response to benthic diatom films [PDF]

, 2009
The role of multi-species benthic diatom films (BDF) in the settlement of late pediveliger larvae of the bivalve Macoma balthica was investigated in still-water bioassays and multiple choice flume experiments.
Vincx, M., Lenoir, J., Backer, A., De, Degraer, S., Ysebaert, T., Colen, C., van, Vanelslander, B.   +6 more
core   +1 more source

Degradation of Poliovirus Sabin 2 Genome After Electron Beam Irradiation

Vaccines
Objectives: Most antiviral vaccines are created by inactivating the virus using chemical methods. The inactivation and production of viral vaccine preparations after the irradiation of viruses with accelerated electrons has a number of significant ...
Dmitry D. Zhdanov, Anastasia N. Shishparenok, Yury Y. Ivin, Anastasia A. Kovpak, Anastasia N. Piniaeva, Igor V. Levin, Sergei V. Budnik, Oleg A. Shilov, Roman S. Churyukin, Lubov E. Agafonova, Alina V. Berezhnova, Victoria V. Shumyantseva, Aydar A. Ishmukhametov   +12 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Evaluation of Residents’ Satisfaction with Cultural Spaces in Historic Districts Based on ERG Theory—A Case Study of Longweiguan Historic and Cultural District in Dali City, China

Buildings
Amid urbanization, historic districts serve as key carriers of urban cultural memory, confronting dual challenges of integrating tradition with modernity and balancing cultural inheritance with spatial renewal.
Zitong Tang, Dingqing Zhang, Lu Zhang, Yingtao Qi, Mengying Wang   +4 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Developing a Holistic Approach for Constructing Rural Living Circles in the Loess Plateau—Taking Yongning Village as an Example

Buildings
Insufficient public service facilities in rural areas, which leads to failures in meeting the needs of villagers, has become a significant barrier to the high-quality development of rural regions.
Mengying Wang, Mingzhi Zhang, Yingtao Qi, Dingqing Zhang, Chenguang Wang, Wenying Yao, Dian Zhou   +6 more
doaj   +1 more source

Assessing urban fire risk in the central business district of Dar es Salaam, Tanzania

Jàmbá, 2010
Buildings as infrastructure along with people’s lives need protection against fire outbreaks. Knowledge on the use of installed facilities is essential in tackling There emergencies, otherwise their installation becomes meaningless.
Yohannes Kachenje, Jacob Kihila, Huba Nguluma   +2 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source