Results 71 to 80 of about 1,332,882 (309)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Approaches to the development of durum wheat cultivars (Triticum durum Desf.) with wide variability of the growing season

Вавиловский журнал генетики и селекции, 2015
Differentiation in the duration of growing period is an inherent and, in many respects, decisive factor of task-oriented formation of the cultivar pool in the region.
P. N. Malchikov, M. G. Myasnikova
doaj   +1 more source

Political Settlements: Issues paper [PDF]

, 2009
Why do similar sets of formal institutions often have such divergent outcomes? An analysis of political settlements goes some way to answering this question by bringing into focus the contending interests that exist within any state, which constrain and ...
Di John, Jonathan, Putzel, James
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Degradation of Poliovirus Sabin 2 Genome After Electron Beam Irradiation

Vaccines
Objectives: Most antiviral vaccines are created by inactivating the virus using chemical methods. The inactivation and production of viral vaccine preparations after the irradiation of viruses with accelerated electrons has a number of significant ...
Dmitry D. Zhdanov, Anastasia N. Shishparenok, Yury Y. Ivin, Anastasia A. Kovpak, Anastasia N. Piniaeva, Igor V. Levin, Sergei V. Budnik, Oleg A. Shilov, Roman S. Churyukin, Lubov E. Agafonova, Alina V. Berezhnova, Victoria V. Shumyantseva, Aydar A. Ishmukhametov   +12 more
doaj   +1 more source

Conflicts Between Dispute Settlement Mechanisms in Regional Trade Agreements and the WTO — What Should WTO Do? [PDF]

, 2009
It was a tremendous pleasure to participate in a symposium that honored one of the giants of the World Trade Organization\u27s (WTO) Appellate Body—Professor Yasuhei Taniguchi.
Hillman, Jennifer A.
core   +2 more sources

Structural behaviour of masonry arch with no-horizontal springing settlement [PDF]

, 2017
This paper presents a calculation procedure for assessing the structural integrity of a masonry arch with non-horizontal springing settlement. By applying the Principle of Virtual Work (PVW) to the deformed arch system, the procedure proposed herein ...
Pellegrino, Carlo, Simoncello, Nicolo', Zampieri, Paolo   +2 more
core   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Evaluation of Residents’ Satisfaction with Cultural Spaces in Historic Districts Based on ERG Theory—A Case Study of Longweiguan Historic and Cultural District in Dali City, China

Buildings
Amid urbanization, historic districts serve as key carriers of urban cultural memory, confronting dual challenges of integrating tradition with modernity and balancing cultural inheritance with spatial renewal.
Zitong Tang, Dingqing Zhang, Lu Zhang, Yingtao Qi, Mengying Wang   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source