Results 71 to 80 of about 449,899 (310)

Plan of Shanghai [cartographic material]

, 1928
This is a reduced copy of the official plan published by the Municipal Council in April 1928, coloured and marked for the purpose of showing the historical particulars required.
Shanghai (China : International Settlement). Municipal Council.
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Exploring the Complex Effects and Their Spatial Associations of the Built Environment on the Vitality of Community Life Circles Using an eXtreme Gradient Boosting–SHapley Additive exPlanations Approach: A Case Study of Xi’an

Buildings
Disentangling the effects of the built environment on urban vitality at the scale of community life circles is crucial for informing precise urban planning and design, particularly in the context of urban renewal.
Keju Liu, Dian Zhou, Yingtao Qi, Mingzhi Zhang, Yulin Ren, Yupeng Wei, Jinghan Wang   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Approaches to the development of durum wheat cultivars (Triticum durum Desf.) with wide variability of the growing season

Вавиловский журнал генетики и селекции, 2015
Differentiation in the duration of growing period is an inherent and, in many respects, decisive factor of task-oriented formation of the cultivar pool in the region.
P. N. Malchikov, M. G. Myasnikova
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Trade dispute settlement mechanisms: the WTO dispute settlement understanding in the wake of the GATT [PDF]

A critical feature of the GATT Uruguay Round negotiations was the establishment of a new and more effective system of dealing with international trade disputes, known as the WTO Dispute Settlement Understanding (DSU). The original GATT dispute settlement
R A Read
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How Does Life Settlement Affect the Primary Life Insurance Market? [PDF]

We study the effect of the life settlement market on the structure of long term contracts offered by the primary market for life insurance, as well as the effect on consumer welfare, using a dynamic model of life insurance with one sided commitment and ...
Hanming Fang, Edward Kung
core   +2 more sources

Greening–degradation paradox in a semi-arid coalfield: Remote sensing evidence of vegetation–soil moisture decoupling and hidden degradation risk

Ecological Indicators
In the transition zone between the Loess Plateau and the Mu Us Sandy Land, apparent vegetation greening can mask ecohydrological stress in coal-mining subsidence areas.
Li Feng, Zhen Du, Qingyang Han, Haotian Liang, Wenzhong Chen, Fan Zhang, Songtao Kou, Linghui Kong, Hao Liu, Maosheng Zhang   +9 more
doaj   +1 more source