Results 61 to 70 of about 5,511 (190)

Development of Deferoxamine‐Functionalized Cyclodextrin Polymer for Targeted Iron Chelation

ChemistryOpen, Volume 14, Issue 10, October 2025.
The cyclodextrin polymer is conjugated with 35 deferoxamine units and can form iron(III) complexes. The polymer exhibits significantly lower antiproliferative activity than free deferoxamine. The cyclodextrin polymer with multiple deferoxamine units may present a promising strategy for improving the efficacy of iron chelation therapies.
Roberta Panebianco, Maurizio Viale, Graziella Vecchio   +2 more
wiley   +1 more source

A randomized, double-blind, placebo-controlled, dose-ranging study using Genz-644470 and sevelamer carbonate in hyperphosphatemic chronic kidney disease patients on hemodialysis

International Journal of Nephrology and Renovascular Disease, 2014
Moustafa Moustafa,1 Lawrence Lehrner,2 Fahd Al-Saghir,3 Mark Smith,4 Sunita Goyal,5 Maureen Dillon,5 John Hunter,5 Randy Holmes-Farley5 1South Carolina Nephrology and Hypertension Center Inc., Orangeburg, SC, USA; 2Kidney Specialists of Southern Nevada ...
Moustafa M, Lehrner L, Al-Saghir F, Smith M, Goyal S, Dillon M, Hunter J, Holmes-Farley R   +7 more
doaj  

Association between sevelamer use and outcomes in acute kidney injury with hyperphosphataemia: evidence from the MIMIC-IV

Frontiers in Pharmacology
BackgroundHyperphosphataemia is consistently linked to adverse clinical outcomes in Acute Kidney Injury (AKI). Sevelamer, a non-calcium phosphate binder widely used in chronic kidney disease (CKD), has not been adequately evaluated for efficacy in AKI ...
Shuzhen Suo, Qilin Yang, Weiyan Chen, Liya Luo, Yongkang Song, Chunxiang Ling, Jianzhong Wang, Deliang Wen, Changbo Liu   +8 more
doaj   +1 more source

Vitamin K antagonists predispose to calciphylaxis in patients with end-stage renal disease. [PDF]

, 2015
BACKGROUND/AIMS: Calciphylaxis is associated with a poor prognosis in dialysis patients, and its pathogenesis remains incompletely understood. Although the use of vitamin K antagonists (VKA) has been implicated, previous reports are conflicting. We aimed
Bardsley, Victoria, El-Damanawi, Ragada, Fry, Andrew C, Galloway, Peter AG, Hiemstra, Thomas F, Ojha, Sanjay K, Pritchard, Nicholas R   +6 more
core   +1 more source

Chronic kidney disease in the primary care setting: A narrative review

Journal of General and Family Medicine, Volume 26, Issue 5, Page 385-393, September 2025.
Abstract Chronic kidney disease (CKD) is a growing public health concern globally, with primary care physicians (PCPs) playing a pivotal role in its early detection and management. This review explores the epidemiology, risk factors, screening strategies, and clinical manifestations of CKD within primary care settings.
Faryal Safdar, Ahsan Aslam
wiley   +1 more source

"Fish-scales" and graft nephrectomy: unexpected findings at an unusual site [PDF]

Journal of Nephropathology, 2017
Background: Kayexalate and sevelamer are resin medications commonly used in the setting of chronic renal failure for the treatment of hyperkalemia and hyperphosphatemia respectively, are known to cause bowel ischemia, ulcerations, necrosis, pseudotumors ...
Smiley Annie George, Issam Francis
doaj   +1 more source

Chronic kidney disease mineral and bone disorder in children [PDF]

, 2007
Childhood and adolescence are crucial times for the development of a healthy skeletal and cardiovascular system. Disordered mineral and bone metabolism accompany chronic kidney disease (CKD) and present significant obstacles to optimal bone strength ...
Katherine Wesseling, Sevcan Bakkaloglu, Isidro Salusky   +2 more
core   +1 more source

Practical use of sevelamer in chronic kidney disease patients on dialysis in People’s Republic of China

Therapeutics and Clinical Risk Management, 2015
Lin Meng,1,2 Bin Fu1 1Department of Nephrology, Second Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 2Tianjin University of Traditional Chinese Medicine, Tianjin, People’s ...
Meng L, Fu B
doaj  

Lack of evidence does not justify neglect. how can we address unmet medical needs in calciphylaxis [PDF]

, 2016
Calcific uraemic arteriolopathy (CUA), or calciphylaxis, is a rare disease predominantly occurring in comorbidity with dialysis. Due to the very low frequency of CUA, prospective studies on its management are lacking and even anecdotal reports on ...
Brandenburg, Vincent Matthias, Cozzolino, Mario, ERA-EDTA Working Group on CKD-MBD, EUCALNET, Evenepoel, Pieter, Floege, Jürgen, Goldsmith, David, Kramann, Rafael, Massy, Ziad, Mazzaferro, Sandro, Schurgers, Leon J., Sinha, Smeeta, Torregrosa, Vicens, Ureña-Torres, Pablo, Vervloet, Marc   +14 more
core   +1 more source

Chronic kidney disease and valvular heart disease: State of the art

Physiological Reports, Volume 13, Issue 18, September 2025.
Abstract Chronic kidney disease (CKD) and valvular heart disease (VHD) frequently coexist and are associated with a significant increase in morbidity and mortality. Their interplay is complex and multifactorial, involving shared pathophysiological mechanisms such as chronic inflammation, mineral and bone disorder, vascular and valvular calcification ...
S. Saltarocchi, M. D'Abramo, P. De Orchi, F. Spunticchia, M. Totaro, E. M. Cirio, F. Miraldi   +6 more
wiley   +1 more source