Results 111 to 120 of about 569,433 (400)

Neurological symptoms, manifestations, and complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19)

Journal of Neurology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, is responsible for the outbreak of coronavirus disease 19 (COVID-19) and was first identified in Wuhan, China in December 2019.
B. Harapan, H. Yoo
semanticscholar   +1 more source

Asthma, severe acute respiratory syndrome coronavirus-2 and coronavirus disease 2019

Current Opinion in Allergy & Clinical Immunology, 2021
Purpose of review In December 2019, a novel respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first described and named coronavirus disease 2019 (COVID-19). Although the knowledge base surrounding COVID-19 and SARS-CoV-2 has grown rapidly, significant gaps in our knowledge remain and
Timberlake, Dylan T., Strothman, Kasey, Grayson, Mitchell H.   +2 more
openaire   +3 more sources

SARS-CoV-2 Infection among Pregnant and Postpartum Women, Kenya, 2020–2021

Emerging Infectious Diseases, 2021
We determined incidence of severe acute respiratory syndrome coronavirus 2 and influenza virus infections among pregnant and postpartum women and their infants in Kenya during 2020–2021.
Nancy A. Otieno, Eduardo Azziz-Baumgartner, Bryan O. Nyawanda, Eunice Oreri, Sascha Ellington, Clayton Onyango, Gideon O. Emukule   +6 more
doaj   +1 more source

Predicting Infectious Severe Acute Respiratory Syndrome Coronavirus 2 From Diagnostic Samples

Clinical Infectious Diseases, 2020
Reverse-transcription polymerase chain reaction (RT-PCR) has become the primary method to diagnose viral diseases, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
J. Bullard, Kerry Dust, D. Funk, J. Strong, D. Alexander, L. Garnett, Carl Boodman, A. Bello, A. Hedley, Zachary Schiffman, Kaylie Doan, N. Bastien, Yan Li, P. V. Van Caeseele, G. Poliquin   +14 more
semanticscholar   +1 more source

Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019

Clinical Infectious Diseases, 2020
Although the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load in respiratory specimens has been widely used to diagnose coronavirus disease 2019 (COVID-19), it is undeniable that serum SARS-CoV-2 nucleic acid ...
Xiaohua Chen, Binghong Zhao, Y. Qu, Yurou Chen, J. Xiong, Yong Feng, Dong Men, Qianchuan Huang, Yanjun Liu, Bo Yang, Jinya Ding, Feng Li   +11 more
semanticscholar   +1 more source

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a review [PDF]

Molecular Cancer, 2020
AbstractIn recent years, the prevalence and spread of coronavirus has had a huge impact on global public health. Due to the incomplete understanding of the pathogenic mechanism of the virus, it is difficult for humans to fight against the virus quickly and effectively once the outbreak occurs. In early 2020, a novel coronavirus was discovered in Wuhan,
Feng Wang, Wei Zong, Wei Feng, Shaoqing Ju   +3 more
openaire   +4 more sources

NMR screening of low molecular weight inhibitors targeting the papain‐like protease (PLPro) of SARS‐CoV‐2

FEBS Open Bio, EarlyView.
Papain‐like protease from SARS‐CoV‐2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR screening study. We identified 86 binding compounds, of which five candidates were chosen for in‐depth analysis.
Dennis J. Pyper, Sridhar Sreeramulu, Benjamin T. Lanham, Elizabeth M. Engle, David Fushman, Harald Schwalbe   +5 more
wiley   +1 more source

Presentation of Severe Acute Respiratory Syndrome-Coronavirus 2 Infection as Cholestatic Jaundice in Two Healthy Adolescents [PDF]

, 2020
© 2020 Elsevier Inc. Liver abnormalities in severe acute respiratory syndrome-coronavirus 2 infection, including hepatitis and cholestasis, have been observed in adults and are associated with worse outcomes.
Ahuja, K. L., Kogan-Liberman, D., Ovchinsky, N., Perez, A., Raizner, A., Sheflin-Findling, S.   +5 more
core   +2 more sources

Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1

Advanced Functional Materials, EarlyView.
This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras, Saahil S. Baghel, Rune F. Jensen, Aneesh Thakur, Henrik Franzyk, Oskar Thofte, Marco Herrera‐Barrera, Madeleine Landry, Melike Ongun, Ahmad Tami, Marlene P. Thanthrige, Eva Callens, Corinne Beinat, Thomas Rades, Søren R. Paludan, Kristian Riesbeck, Ida Rosenkrands, Dennis Christensen, Gabriel K. Pedersen, Camilla Foged   +19 more
wiley   +1 more source

Angiotensin-Converting Enzyme Inhibitor / Angiotensin II Receptor Blocker in COVID-19: a Double-edged Sword or a Myth

Nepalese Medical Journal, 2020
Angiotensin-converting enzyme-2 receptor has been unearthed as a prime site of entry of Severe Acute Respiratory Syndrome Coronavirus 2 owing to its strong affinity towards spike protein of Severe Acute Respiratory Syndrome Coronavirus 2, resulting in ...
Kunal Bikram Shaha, Ashok Adhikari, Jung Rae Cho, Bimal Pandey, Yubaraj Sharma, Sajjad Safi   +5 more
doaj   +1 more source