Results 251 to 260 of about 622,897 (403)

Crystallographic fragment screening against SARS‐CoV‐2 nonstructural protein 1 using the F2X‐Entry Screen and a newly developed fragment library

Acta Crystallographica Section D, EarlyView.
Two crystallographic fragment screening campaigns against SARS‐CoV‐2 nonstructural protein 1 resulted in the identification of 21 new hits.Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continues to threaten global health. This underpins the need for novel therapeutics against this virus.
Frank Lennartz, Jan Wollenhaupt, Melanie Oelker, Paula Fröling, Uwe Mueller, Anke Deckers, Christoph Grathwol, Stefan Bräse, Nicole Jung, Manfred S. Weiss   +9 more
wiley   +1 more source

Emergency department presentations, hospitalisations and police seizure data related to gamma‐hydroxybutyrate (GHB) in New South Wales, Australia, from 2015 to 2024

Addiction, EarlyView.
Abstract Background and aims Gamma‐hydroxybutyrate (GHB) is an endogenous neurochemical and illicit synthetic drug. Its precursors, gamma‐butyrolactone (GBL) and 1,4‐butanediol (1,4‐BD), are often used as substitutes. We aimed to describe GHB‐related harms in New South Wales (NSW), Australia.
Krista J. Siefried, Janette L. Smith, Christine A. Harvey, Anthony Nedanoski, Jared A. Brown, Una Cullinan, Nadine Ezard, Thanjira Jiranantakan, Darren M. Roberts, Jonathan Brett   +9 more
wiley   +1 more source

Community-Onset Bacterial Coinfection in Children Critically Ill With Severe Acute Respiratory Syndrome Coronavirus 2 Infection [PDF]

, 2023
Kristin Moffitt, Mari Nakamura, Cameron C. Young, Margaret M. Newhams, Natasha Halasa, J Reed, Julie Fitzgerald, Philip C. Spinella, Vijaya L Soma, Tracie C. Walker, Laura L. Loftis, Aline B. Maddux, Michele Kong, Courtney M. Rowan, Charlotte V. Hobbs, Jennifer E. Schuster, Becky J. Riggs, Gwenn E. McLaughlin, Kelly N. Michelson, Mark W. Hall, Christopher J. Babbitt, Natalie Z. Cvijanovich, Matt S. Zinter, Mia Maamari, Adam J. Schwarz, Aalok R. Singh, Heidi R. Flori, Shira J. Gertz, Mary Allen Staat, John S. Giuliano, Saul Hymes, Katharine N. Clouser, John K. McGuire, Christopher L. Carroll, Neal J. Thomas, Emily R. Levy, Adrienne G. Randolph   +36 more
openalex   +1 more source

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response

Diabetes & Metabolic syndrome: clinical Research & Reviews, 2020
I. Astuti, Ysrafil
semanticscholar   +1 more source

Efficacy of combined varenicline and nicotine replacement therapy compared with varenicline or nicotine replacement therapy alone for smoking cessation: A systematic review and meta‐analysis

Addiction, EarlyView.
Abstract Aims To assess whether combining nicotine replacement therapy (NRT) with varenicline improves long‐term smoking cessation rates compared with varenicline or NRT alone. Method Systematic review and meta‐analysis of randomized controlled trials (RCTs) or quasi‐RCTs, conducted according to PRISMA guidelines.
Xinmei Zhou, Zhenxiao Huang, Qingqing Song, Xin Xia, Anqi Cheng, Zhao Liu, Min Wang, Tingfen Ji, Ailifeire Aihemaiti, Ying Xie, Yi Liu, Yuxin Shi, Shunyi Shi, Yingman Gao, Hang Liu, Jiahui He, Liang Zhao, Dan Xiao, Chen Wang   +18 more
wiley   +1 more source

Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Facts and myths

Journal of Microbiology, Immunology and Infection, 2020
Chih-Cheng Lai, Yen-Hung Liu, Cheng-Yi Wang, Ya-Hui Wang, Shun-Chung Hsueh, M.-Y. Yen, W. Ko, P. Hsueh   +7 more
semanticscholar   +1 more source

Immune Training of the Interleukin 6 Gene in Airway Epithelial Cells is Central to Asthma Exacerbations

Allergy, EarlyView.
This study aims to investigate how immune activation influences the epigenetic regulation and expression of the Interleukin‐6 (IL‐6) gene during asthma exacerbations. By examining molecular mechanisms of immune training, we seek to elucidate how IL‐6‐driven inflammatory pathways contribute to airway dysfunction and worsening asthma symptoms.
Lars P. Lunding, Markus Weckmann, Ulrich M. Zissler, Constanze Jakwerth, Rebecca Bodenstein‐Sgró, Sina Webering, Christina Vock, Johanna C. Ehlers, Romina A. M. Fernandez Ceballos, Sai Sneha Priya Nemani, Karosham Diren Reddy, Brian George G. Oliver, Cornelis J. Vermeulen, Maarten van de Berge, Carole Ober, Axel Künstner, Hauke Busch, Inke König, Christoph Garbers, Carsten B. Schmidt‐Weber, Marcel F. Nold, Ali Önder Yildirim, Claudia A. Nold‐Petry, Zane Orinska, Thomas Bahmer, Jan Heyckendorf, Gesine Hansen, Erika von Mutius, Klaus F. Rabe, Anna‐Maria Dittrich, Bianca Schaub, Folke Brinkmann, Matthias V. Kopp, Michael Wegmann, The ALLIANCE Study Group as part of the German Centre for Lung Research (DZL)   +34 more
wiley   +1 more source

Vaccinations During Pregnancy Protect the Mother–Infant Dyad and Are Generally Safe

Acta Paediatrica, EarlyView.
ABSTRACT Aim Vaccination in pregnancy has a critical impact on mothers, foetuses and infants. The aim of this paper was to summarise key points presented by experts attending the 12th Maria Delivoria‐Papadopoulos Perinatal Symposium in March 2025 and further expand and update them.
Ariadne Malamitsi‐Puchner, Despina D. Briana, Gian Carlo Di Renzo   +2 more
wiley   +1 more source

Low ICU Admission and Excellent Outcomes in MIS‐C: A Swedish Study From an Open Society

Acta Paediatrica, EarlyView.
ABSTRACT Aim During the COVID‐19 pandemic, Sweden chose a more open public health approach. A general concern was that this approach would affect the population negatively. We describe the Swedish national MIS‐C cohort and risk factors for severe disease defined as admission to the intensive care unit and cardiogenic shock.
Petra Król, Maria Altman, Stefan Berg, Lillemor Berntson, Petter Brodin, Anders Fasth, Robin Kahn, Jenny Lingman Framme, Maria Mossberg, Charlotta Nordenhäll, Karin Palmblad, André Rudolph, Eva Säve‐Söderbergh, AnnaCarin Horne   +13 more
wiley   +1 more source

The role of ozone therapy in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19)

, 2023
Biyan Nathanael Harapan, Triswan Harapan
openalex   +1 more source