Results 131 to 140 of about 3,688,287 (401)

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

Allergy in severe asthma [PDF]

, 2017
It is well recognized that atopic sensitisation is an important risk factor for asthma, both in adults and in children. However, the role of allergy in severe asthma is still under debate. The term "Severe Asthma" encompasses a highly heterogeneous group
Bakirtas, Arzu, Bel, Elizabeth, Bjermer, Leif, Custovic, Adnan, DEL GIACCO, STEFANO, Diamant, Zuzana, Hamelmann, Eckard, Heffler, Enrico, Kalayci, Ömer, Saglani, Sejal, Sergejeva, Svetlana, Seys, Sven, Simpson, Angela   +12 more
core   +1 more source

Multiview Cluster Analysis Identifies Variable Corticosteroid Response Phenotypes in Severe Asthma.

American Journal of Respiratory and Critical Care Medicine, 2019
Rationale: Corticosteroids (CSs) are the most effective asthma therapy, but responses are heterogeneous and systemic CSs lead to long-term side effects.
Wei Wu, Seo-Jin Bang, E. Bleecker, M. Castro, Loren C Denlinger, S. Erzurum, J. Fahy, A. Fitzpatrick, B. Gaston, A. Hastie, E. Israel, N. Jarjour, B. Levy, D. Mauger, D. Meyers, W. Moore, M. Peters, B. Phillips, W. Phipatanakul, R. Sorkness, S. Wenzel   +20 more
semanticscholar   +1 more source

Artificial Intelligence‐Driven Soft Bioelectronics for Self‐Powered Respiration Monitoring

Advanced Science, EarlyView.
Artificial intelligence‐driven soft bioelectronics for self powered respiration monitoring based on triboelectric nanogenerators (TENGs), piezoelectric nanogenerators (PENGs), and magnetoelastic generators (MEGs) enable continuous and multi‐scenario respiratory biomechanical data collection. Coupled with machine learning and big data driven diagnostics,
Xinkai Xu, Xiao Xiao, Rui Guo, Jun Chen
wiley   +1 more source

Omalizumab as alternative to chronic use of oral corticosteroids in severe asthma

, 2019
Systemic/oral corticosteroids (OCS) have been used for decades in the management of acute asthma exacerbations and chronically in patients with uncontrolled severe asthma.
Bousquet, Jean, Brusselle, Guy, Buhl, Roland, Katsaounou, Paraskevi, Martinez, Rafael, Pfister, Pascal, Wahn, Ulrich   +6 more
core   +1 more source

Childhood and Parental Asthma, Future Risk of Bipolar Disorder and Schizophrenia Spectrum Disorders: A Population-Based Cohort Study [PDF]

, 2018
BACKGROUND: Mounting evidence implicates early life and prenatal immune disturbances in the etiology of severe mental illnesses. Asthma is a common illness associated with chronic aberrant immune responses.
Dalman, C, Gardner, R, Hayes, JF, Karlsson, H, Lewis, G, Osborn, D, Wu, Q   +6 more
core   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

The burden of severe asthma in sub-Saharan Africa: Findings from the African Severe Asthma Project

Journal of Allergy and Clinical Immunology: Global
Background: Severe asthma is associated with high morbidity, mortality, and health care utilization, but its burden in Africa is unknown. Objective: We sought to determine the burden (prevalence, mortality, and activity and work impairment) of severe ...
Bruce J. Kirenga, MBChB, MMed, PhD, Jeremiah Chakaya, MBChB, MMed, Getnet Yimer, MD, PhD, George Nyale, MBChB, MMed, Tewodros Haile, MD, Winters Muttamba, MBChB, MPH, Levicatus Mugenyi, PhD, Winceslaus Katagira, MBChB, MMed, William Worodria, MBChB, MMed, PhD, Hellen Aanyu-Tukamuhebwa, MBChB, MMed, Njira Lugogo, MD, Moses Joloba, MBChB, MS, PhD, Tesfaye B. Mersha, PhD, Amsalu Bekele, MD, Fred Makumbi, PhD, Amha Mekasha, PhD, Cynthia L. Green, PhD, Corina de Jong, PhD, Moses Kamya, MBChB, MMed, MPH, PhD, Thys van der Molen, MD, PhD   +19 more
doaj   +1 more source

Burden of asthma exacerbations and health care utilization in pediatric patients with asthma in the US and England

Immunity, Inflammation and Disease, 2020
Background Data on asthma burden in pediatric patients are limited; this real‐world study investigated exacerbation frequency and health care resource utilization (HCRU) in pediatric asthma patients from the US and England.
Mugdha Gokhale, Takako Hattori, Lee Evitt, Warren Lenney, Beth Nordstrom, Jenna Collins, Anna Schultze, Melissa K. Van Dyke   +7 more
doaj   +1 more source

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source