Results 141 to 150 of about 313,837 (264)

Maternal and infant gut microbiome

iMeta, EarlyView.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang, Felicia Tin, Hui Chen, Fuxin Jiao, Min Wu, Shanshan Sun, Lisha Lin, Die Li, Huimin Zheng, Zhenxin Niu, Mengyao Lan, Bahtiyar Yilmaz, Johan G. Eriksson, Mengjia Wang, Andrew Macpherson, Jose C. Clemente, Jia Xu, Ri‐hua Xie, Xiaojiao Zheng, Tao Zhou, Jinfeng Wang, Wei Shen, Bing Huang, Xia Chen, Hai Li, Yan He   +25 more
wiley   +1 more source

Clinical outcomes and remission trajectories in obese and non-obese patients with severe asthma treated with biologics: a retrospective longitudinal cohort study from the Severe Asthma Network Italy (SANI) registry. [PDF]

Lancet Reg Health Eur
Di Bona D, Di Gioia G, Heffler E, Parente R, Serviddio G, Blasi F, Paggiaro P, Canonica GW, SANI network.   +8 more
europepmc   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Unexpected erythema nodosum during dupilumab treatment for severe asthma: Causal or casual? [PDF]

JAAD Case Rep
Cusumano F, Brazzelli V, Taietti I, Marseglia A, Castagnoli R, Marseglia GL, Licari A.   +6 more
europepmc   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Cannabichromeorcin targets cathepsin L to alleviate oxidative stress-Driven airway inflammation in severe asthma. [PDF]

Redox Biol
Huang J, Chen Y, Deng Y, Hu D, Chen Y, Li Y, Xie C, Fan K, Zhu B, Gong Z, Yang J, Huang S, Peng X, Peng X, Huang B, Zhao W, Du Q, Zhao H.   +17 more
europepmc   +1 more source

sFlt‐1/PlGF Ratio in the Diagnosis of Preeclampsia on the MAGLUMI X3 Analyzer

Journal of Clinical Laboratory Analysis, EarlyView.
We compared the analytical and clinical performance of MAGLUMI X3 (Snibe) and Elecsys (Roche) for measuring sFlt‐1, PlGF, and their ratio in women hospitalized at the Department of Gynecology and Obstetrics, University Hospital in Pilsen. In a single‐center, real‐world cohort (192 samples from 164 patients), method comparison showed good agreement ...
Pavel Broz, Simona Kukralova, Zdenek Sebesta, Katerina Brslicova, Michal Kozerovsky, Jaroslav Racek, Daniel Rajdl   +6 more
wiley   +1 more source

Clinical Remission in Severe Asthma: A Comparative Analysis of Patients with and Without Biologics from the Swiss Severe Asthma Registry. [PDF]

Biomedicines
Jaun F, Boesing M, Lüthi-Corridori G, Bridevaux PO, Charbonnier F, Clarenbach CF, Fellrath JM, Gianella P, Jochmann A, Kern L, Pavlov N, Latshang TD, Von Garnier C, Leuppi JD.   +13 more
europepmc   +1 more source

A Comprehensive Study of Bidirectional Interactions Between the Human Microbiome and Blood Malignancies and Hematologic Conditions: Focus on Novel Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Microbiota‐targeted therapeutic strategies in hematological disorders. aHSCT: Transplanted immune cells from the donor may attack the recipient's tissues, especially when damage to the intestinal epithelium disrupts the gut microbiota, contributing to GVHD. Maintaining a balanced gut microbiota that supports immune regulation helps reduce GVHD risk and
Alireza Molajafari, Hadi Sedigh Ebrahim‐Saraie, Majid Taati Moghadam, Meysam Hasannejad‐Bibalan   +3 more
wiley   +1 more source

Do biologics improve health outcomes in children with severe asthma? A cohort study. [PDF]

ERJ Open Res
Quach S, Nonoyama M, Moraes TJ, Finkelstein Y, Balkovec S, Subbarao P, To T.   +6 more
europepmc   +1 more source