Results 131 to 140 of about 4,122,734 (351)

Gender aspects and influence of hormones on bronchial asthma – Secondary publication and update

World Allergy Organization Journal, 2017
There is good evidence for gender-specific differences in asthma regarding all affected areas, from intra- to extra-cellular mediators to the whole organ structure und functioning of the lung.
Iris Koper, Karin Hufnagl, Rainer Ehmann
doaj   +1 more source

New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma [PDF]

, 2017
Introduction: Inhaled corticosteroids (ICS) alone or in combination with an inhaled long-acting beta2-agonist (LABA) are the preferred long-term treatment for adults and adolescents with symptomatic asthma.
Thomson, Neil C.
core   +1 more source

Targeting treatable traits in severe asthma: a randomised controlled trial

European Respiratory Journal, 2019
Rationale Treatable traits have been proposed as a new paradigm for airway disease management. Objectives To characterise treatable traits in a severe asthma population and to determine the efficacy of targeting treatments to these treatable traits in ...
V. McDonald, Vanessa L. Clark, Laura Cordova-Rivera, P. Wark, K. Baines, P. Gibson   +5 more
semanticscholar   +1 more source

Early and Sustained Improvements in Sense of Smell With Tezepelumab Treatment in Patients With Chronic Rhinosinusitis With Nasal Polyps (WAYPOINT)

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Loss of smell is a principal symptom of chronic rhinosinusitis with nasal polyps (CRSwNP), affecting health‐related quality of life and posing a safety hazard. Methods WAYPOINT (NCT04851964), a phase 3, multicenter trial in adults with uncontrolled CRSwNP, randomized patients 1:1 to receive tezepelumab 210 mg or placebo ...
Joaquim Mullol, Joseph K. Han, Tanya M. Laidlaw, Claire Hopkins, Anju T. Peters, Oliver Pfaar, Martin Desrosiers, Stella E. Lee, Andrew P. Lane, Claudia Chen, Yun Chon, Sandhia S. Ponnarambil, Andrew Foster, Andrew W. Lindsley, Christopher S. Ambrose   +14 more
wiley   +1 more source

Asthma Is More Severe in Older Adults.

PLoS ONE, 2015
BackgroundSevere asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is independent of asthma duration.MethodsThis is a cross-sectional study of prospectively
Joe G Zein, Raed A Dweik, Suzy A Comhair, Eugene R Bleecker, Wendy C Moore, Stephen P Peters, William W Busse, Nizar N Jarjour, William J Calhoun, Mario Castro, K Fan Chung, Anne Fitzpatrick, Elliot Israel, W Gerald Teague, Sally E Wenzel, Thomas E Love, Benjamin M Gaston, Serpil C Erzurum, Severe Asthma Research Program   +18 more
doaj   +1 more source

Efficacy of azithromycin in severe asthma from the AMAZES randomised trial

ERJ Open Research, 2019
Background Low-dose azithromycin is an effective therapy for persistent asthma; however, its benefit in severe asthma is not defined. Methods Participants with severe asthma were identified from the AMAZES randomised, placebo-controlled trial of long ...
Peter G. Gibson, Ian A. Yang, John W. Upham, Paul N. Reynolds, Sandra Hodge, Alan L. James, Christine Jenkins, Matthew J. Peters, Guy B. Marks, Melissa Baraket, Heather Powell, Jodie L. Simpson   +11 more
doaj   +1 more source

Local Specific IgE Levels Can Predict and Monitor the Therapeutic Response to Subcutaneous Immunotherapy With House Dust Mite

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Identifying predictive and monitoring biomarkers for allergen immunotherapy response is crucial for enhancing clinical efficacy. This study aims to investigate the systemic and local levels of immunoglobulins and identify potential biomarkers in house dust mite (HDM) allergic rhinitis (AR) patients who are undergoing subcutaneous ...
Xu Xu, Jingyun Li, Xu Zhang, Yu Song, Lin Xi, Luo Zhang, Yuan Zhang   +6 more
wiley   +1 more source

The burden of severe asthma in sub-Saharan Africa: Findings from the African Severe Asthma Project

Journal of Allergy and Clinical Immunology: Global
Background: Severe asthma is associated with high morbidity, mortality, and health care utilization, but its burden in Africa is unknown. Objective: We sought to determine the burden (prevalence, mortality, and activity and work impairment) of severe ...
Bruce J. Kirenga, MBChB, MMed, PhD, Jeremiah Chakaya, MBChB, MMed, Getnet Yimer, MD, PhD, George Nyale, MBChB, MMed, Tewodros Haile, MD, Winters Muttamba, MBChB, MPH, Levicatus Mugenyi, PhD, Winceslaus Katagira, MBChB, MMed, William Worodria, MBChB, MMed, PhD, Hellen Aanyu-Tukamuhebwa, MBChB, MMed, Njira Lugogo, MD, Moses Joloba, MBChB, MS, PhD, Tesfaye B. Mersha, PhD, Amsalu Bekele, MD, Fred Makumbi, PhD, Amha Mekasha, PhD, Cynthia L. Green, PhD, Corina de Jong, PhD, Moses Kamya, MBChB, MMed, MPH, PhD, Thys van der Molen, MD, PhD   +19 more
doaj   +1 more source

Severe bronchial asthma in children with exercise-induced bronchospasm [PDF]

, 2017
Based on a complex examination 46 of schoolchildren suffering from severe asthma, we established that greater proportion of schoolchildren with exercise-induced asthma was with symptoms of mucospin hypereosinophilia (average content of eosinophilic ...
Basіuk, N.V., Garas, M.N., Lekhkun, H.V., Lysenko, V.V.   +3 more
core  

A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED [PDF]

, 2016
RATIONALE AND OBJECTIVES: Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms. We used transcriptomic profiling of airway tissues to help define asthma phenotypes. METHODS: The transcriptome from bronchial biopsies
Adcock, IM, Auffray, C, Baribaud, F, Chanez, P, Chung, KF, Corfield, J, Dahlen, B, Dahlen, SE, De Meulder, B, Djukanovic, R, Fleming, L, Fowler, S, Guo, Y, Hoda, U, Howarth, P, Krug, N, Kuo, CS, Lefaudeux, D, Loza, M, Pandis, I, Pavlidis, S, Rossios, C, Rowe, A, Sandström, T, Shaw, D, Sousa, A, Sterk, PJ, U-BIOPRED Project Team, Wilson, SJ   +28 more
core   +4 more sources