Results 141 to 150 of about 3,446,938 (405)

Systemic autoimmune rheumatic disease risk is associated with long‐term exposure to fine particulate matter

Arthritis &Rheumatology, Accepted Article.
Objective Fine particulate matter (PM2.5) is a possible trigger of systemic autoimmune rheumatic diseases (SARDs). We investigated SARDs risk related to long‐term exposure to PM2.5 and its components (ammonium, black carbon, mineral dust, sea salt, nitrate, sulfate, organic matter), the composition of which may affect toxicity.
Mareva Geslin, Julien Vachon, Naizhuo Zhao, Elhadji Anassour Laouan Sidi, Sonia Jean, Audrey Smargiassi, Sasha Bernatsky   +6 more
wiley   +1 more source

Targeting NLRP3 Inflammasome Activation in Severe Asthma

Journal of Clinical Medicine, 2019
Severe asthma (SA) is a chronic lung disease characterized by recurring symptoms of reversible airflow obstruction, airway hyper-responsiveness (AHR), and inflammation that is resistant to currently employed treatments.
Efthymia Theofani, M. Semitekolou, I. Morianos, K. Samitas, G. Xanthou   +4 more
semanticscholar   +1 more source

Pharmacology and safety of TAS5315, a Bruton tyrosine kinase inhibitor, in healthy volunteers: First‐in‐human, randomized, ascending‐dose studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim TAS5315 is a Bruton tyrosine kinase (Btk) inhibitor in development for autoimmune and allergic diseases, including rheumatoid arthritis (RA) and chronic spontaneous urticaria (CSU). Two clinical studies evaluated the pharmacology and safety of single and multiple oral doses of TAS5315.
Yuji Kumagai, Tomoe Fujita, Mika Maeda, Akiko Yamamoto, Hideki Amano   +4 more
wiley   +1 more source

Combination formoterol and inhaled steroid versus beta(2)-agonist as relief medication for chronic asthma in adults and children (Review) [PDF]

, 2009
Background Formoterol has a fast onset of action and can therefore be used to relieve symptoms of asthma. A combination inhaler can deliver formoterol with different doses of inhaled corticosteroid; when used as a reliever both drugs will be delivered ...
Adams, Balanzat, Berggren, Bisgaard, Bisgaard, Bleecker, Bousquet, British Thoracic Society, Bruce, Buhl, Buhl, Cates, Christopher, Greenstone, Haahtela, Haahtela, Higgins, Higgins, Ind, Johansson, Jonkers, Kuna, Kuna, Lundborg, Ni Chroinin, O'Byrne, O'Byrne, O'Byrne, O'Byrne, O'Byrne, Palmqvist, Price, Price, Rabe, Rabe, Rabe, Richter, Salpeter, Scicchitano, Sears, Sovani, Stallberg, Tattersfield, Tattersfield, Vogelmeier, Vogelmeier, Walters   +46 more
core   +1 more source

Baseline patient factors impact on the clinical efficacy of benralizumab for severe asthma

European Respiratory Journal, 2018
Benralizumab is an anti-eosinophilic monoclonal antibody that reduces exacerbations and improves lung function for patients with severe, uncontrolled asthma with eosinophilic inflammation.
E. Bleecker, M. Wechsler, J. FitzGerald, A. Menzies-Gow, Yanping Wu, I. Hirsch, M. Goldman, P. Newbold, J. Zangrilli   +8 more
semanticscholar   +1 more source

Drug–drug interaction profile of ritlecitinib as perpetrator and victim through cytochrome P450

British Journal of Clinical Pharmacology, EarlyView.
Aims To assess the effect of a potent cytochrome P450 (CYP) 3A inhibitor and CYP inducer on the pharmacokinetics of ritlecitinib, a JAK3/TEC family kinase inhibitor, and assess the effect of ritlecitinib on the pharmacokinetics of CYP substrates (midazolam, efavirenz, tolbutamide, caffeine and oral contraceptives [ethinyl oestradiol and levonorgestrel])
Vivek S. Purohit, Yeamin Huh, Martin E. Dowty, Anna Plotka, Alexandre Lejeune, Hindu Kalluru, Brian Hee   +6 more
wiley   +1 more source

Innate and adaptive T cells in asthmatic patients: relationship to severity and disease mechanisms [PDF]

, 2015
BackgroundAsthma is a chronic inflammatory disease involving diverse cells and mediators whose interconnectivity and relationships to asthma severity are unclear.ObjectiveWe performed a comprehensive assessment of TH17 cells, regulatory T cells, mucosal ...
Dimitrov, Borislav D., Djukanović, Ratko, Gadola, Stephan D., Hinks, Timothy, Howarth, Peter H., Lum, Pek Y., Manta, Alexander, Petrossian, Tanya, Smith, Caroline G., Staples, Karl J., Walls, Andrew F., Ward, Jon A., Zhou, Xiaoying   +12 more
core   +1 more source

Burden of asthma exacerbations and health care utilization in pediatric patients with asthma in the US and England

Immunity, Inflammation and Disease, 2020
Background Data on asthma burden in pediatric patients are limited; this real‐world study investigated exacerbation frequency and health care resource utilization (HCRU) in pediatric asthma patients from the US and England.
Mugdha Gokhale, Takako Hattori, Lee Evitt, Warren Lenney, Beth Nordstrom, Jenna Collins, Anna Schultze, Melissa K. Van Dyke   +7 more
doaj   +1 more source

Prescribing competence: The pros and cons of different methods for assessment

British Journal of Clinical Pharmacology, EarlyView.
Evaluating a medical graduate’s competence in rational prescribing is challenging. With the aim to guide and inspire teachers, this narrative review explores different methods that can be used to assess prescribing competence. Each method has its own advantages and disadvantages, and thus a mix of different assessment methods is needed throughout the ...
David J. Brinkman, Erik M. Donker, Jelle Tichelaar, on behalf of the CP4T programme   +3 more
wiley   +1 more source

Immunomodulatory and biologic therapies for severe refractory asthma [PDF]

, 2008
SummaryDespite undoubted efficacy of the combination of inhaled corticosteroids and β2-agonists for most asthmatic patients with moderate-to-severe disease, there remains ∼10% of the asthmatic population with serious unremitting symptoms, resulting in ...
Aaron, Akinbami, Alexander, Antoncelli, Ball, Banerjee, Barnes, Bernstein, Bernstein, Berry, Black, Bongartz, Boulet, Bousquet, Bousquet, Busse, Calderon, Chipps, Coffey, Comet, Corrigan, Cox, Davies, Dean, Dougados, Dyer, Erin, Erzurum, Evans, Evans, Evans, Fahy, Feldmann, Finn, Fleischmann, Fukuda, Garey, Global Initiative for Asthma, Godard, Gotfried, Gould, Heaney, Hedman, Hodges, Holgate, Holgate, Howarth, Humbert, Itkin, Jaymin Morjaria, Johnston, Kamada, Kanzow, Keystone, Khan, Klaustermeyer, Kornbluth, Limb, Lock, Marin, Milgrom, Milgrom, Moore, Morjaria, Morjaria, Mullarkey, Mullarkey, Muranaka, Nelson, Nierop, Nizankowska, Nizankowska, Ogirala, Presta, Reid, Riccardo Polosa, Salmon, Sandborn, Serra-Batlles, Shields, Shiner, Shiner, Sihra, Simpson, Solèr, Spector, Stewart, Szczeklik, Szczeklik, Szefler, Taylor, Trigg, Walker, Wenzel   +93 more
core   +1 more source