Results 171 to 180 of about 2,200,340 (304)

Inhaled corticosteroid adherence in the era of biologics for severe asthma. [PDF]

ERJ Open Res
Nolasco S, Crimi C.
europepmc   +1 more source

System‐Local Axes and Metabolic Reprogramming From Health to Response in House Dust Mite‐Specific Subcutaneous Immunotherapy for Allergic Rhinitis

iMetaMed, EarlyView.
This study delineated nasal‐plasma metabolic reprogramming in house dust mite‐allergic rhinitis (HDM‐AR) and subcutaneous immunotherapy (SCIT) response, showing compartment‐specific signatures dominated by nasal lipid‐redox and plasma nucleotide‐NAD+ axes and across the HC–HDM‐AR–SCIT response continuum, dual‑compartment metabolites exhibited ...
Bixing Fang, Fei Pan, Yachun Li, Yimeng Wang, Ze Wang, Zhiheng Huang, Ming Chen, Yun Li, Mengli Huang, Cheng Guo, Chubo Xie, Lina Dong, Yadong Gao, Zhuohang Yu   +13 more
wiley   +1 more source

A Multi-Compartment Cytological Approach to Severe Asthma Phenotyping: The BRISA Study (Biomedical Research in Severe Asthma). [PDF]

J Asthma Allergy
Domínguez-Ortega J, Leon-Zambrana G, Cañas JA, García-Moguel I, Igea JM, Valverde-Monge M, Caballero ML, Gandolfo-Cano M, De Las Vecillas L, Quirce S, Del Pozo V.   +10 more
europepmc   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Monosensitization vs Polysensitization in Severe Asthma: Implications for Disease Severity [PDF]

Marina Gueçamburu,1 Axelle Dupont,2 Bernice Djidonou,3 Charlotte Thibaut de Ménonville,4 Leyla Barakat,5 Félix Laborier,5 Mathilde Le Brun,5 Clairelyne Dupin,5 Catherine Neukirch,5 Camille Taillé5 1Service des Maladies Respiratoires et des épreuves ...
Dupont A, Gueçamburu M, Le Brun M, Taillé C, Thibaut de Ménonville C, Djidonou B, Barakat L, Neukirch C, Dupin C, Laborier F   +9 more
core  

High‐Sugar Diet and Intestinal Diseases: A Shared Microbiota–Barrier–Immunity–Metabolism Axis in Inflammatory Bowel Disease, Food Allergy, and Colorectal Cancer

iNew Medicine, EarlyView.
ABSTRACT The global incidence of intestinal diseases—including food allergy, inflammatory bowel disease (IBD), and colorectal cancer (CRC)—continues to escalate in parallel with the expansion of the “Western diet,” within which the high‐sugar diet (HSD) has emerged as a pivotal yet under‐recognized dietary driver.
Yuchen Wang, Yajuan Wu, Huayang Sheng, Shouhong Jiang, Jinping Cheng, Ye Kuang, Miao Liu, Lei Feng, Yanan Sun, Jinzhi Duan   +9 more
wiley   +1 more source

Adverse outcomes in young adults with severe asthma: results from the UK Severe Asthma Registry. [PDF]

ERJ Open Res
Holmes LJ, Redmond C, Heaney L, Busby J, Brown T, Burhan H, Chaudhuri R, Idris E, Nanzer AM, Mansur AH, Naveed S, Patel P, Hayes G, Rupani H, Sammut D, Subramanian D, Pfeffer P, Fowler SJ.   +17 more
europepmc   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Tracking severe asthma improvement with biologic therapy using spirometry and impulse oscillometry: a real-world study. [PDF]

Multidiscip Respir Med
Chiei Gallo A, Ventura L, Caron L, Guglieri M, Bono E, Iemoli E, Carpagnano GE, Portacci A, Tursi F, Ortolani V.   +9 more
europepmc   +1 more source

Spreading quality improvement in bronchiolitis care: A qualitative study of barriers and facilitators to de‐implementation efforts across Alberta′s healthcare settings

Journal of Hospital Medicine, EarlyView.
Abstract Background Low‐value care remains prevalent in bronchiolitis management despite evidence‐based guidelines. De‐implementation initiatives face unique challenges compared with traditional implementation efforts, particularly when spreading across diverse healthcare settings.
Nathan M. Solbak, Ashleigh Jensen, Erin Thompson, Aaron Peterson, Lily Ragan, Daina Thomas, David W. Johnson, J. A. Michelle Bailey   +7 more
wiley   +1 more source