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Immunopathogenesis of Severe Asthma
Current Pharmaceutical Design, 2011Severe asthma is a complex heterogeneous disease with substantial unmet clinical need. Understanding the immunopathogenesis is likely to provide insights into potential novel therapies. To date researchers have focussed primarily at a single scale for example genome, cell or whole organ physiology.
Brightling, CE +4 more
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Exacerbations of severe asthma
Clinical & Experimental Allergy, 2012SummaryExacerbations occur frequently in severe asthma. They result in significant morbidity and can lead to hospitalization and death. Severe exacerbations can also lead to an accelerated decline in lung function. Phenotyping severe asthma can aid with both prognostication of exacerbation risk and maintenance treatment selection to minimize future ...
McDonald, V. M., Gibson, P. G.
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Clinical & Experimental Allergy, 2012
SummaryPatients with severe asthma have asthma symptoms which are difficult to control, require high dosages of medication, and continue to experience persistent symptoms, asthma exacerbations or airflow obstruction. Epidemiological and clinical evidences point to the fact that severe asthma is not a single phenotype.
A H, Poon +4 more
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SummaryPatients with severe asthma have asthma symptoms which are difficult to control, require high dosages of medication, and continue to experience persistent symptoms, asthma exacerbations or airflow obstruction. Epidemiological and clinical evidences point to the fact that severe asthma is not a single phenotype.
A H, Poon +4 more
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The Lancet, 1998
peribronchial tissues. Eosinophilic myocarditis is a rare feature observed in various clinical situations; it can be isolated and idiopathic, or induced by drugs (such as antibiotics and carbamazepine). By contrast, the association of eosinophilic myocarditis with severe bronchial asthma, an eosinophil count of more than 10%, and history of severe food
RABUSIN M +3 more
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peribronchial tissues. Eosinophilic myocarditis is a rare feature observed in various clinical situations; it can be isolated and idiopathic, or induced by drugs (such as antibiotics and carbamazepine). By contrast, the association of eosinophilic myocarditis with severe bronchial asthma, an eosinophil count of more than 10%, and history of severe food
RABUSIN M +3 more
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Chest, 2003
Severe asthma is poorly understood clinically, physiologically, and pathologically. While milder forms of asthma are generally easily treated, more severe forms often remain refractory to the best current medical care. Although some patients with severe asthma have had severe disease for most of their lives, there appears to be a second group that ...
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Severe asthma is poorly understood clinically, physiologically, and pathologically. While milder forms of asthma are generally easily treated, more severe forms often remain refractory to the best current medical care. Although some patients with severe asthma have had severe disease for most of their lives, there appears to be a second group that ...
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Severe Exacerbations of Asthma
Critical Care Nursing Quarterly, 2004All asthmatics regardless of their perceived severity, are at risk of exacerbation, particularly if they are suboptimally treated in the outpatient arena. Fortunately most patients recover after administration of bronchodilators and anti-inflammatory medications, but preventable deaths continue to occur and refractory cases result in hospitalization ...
Susan J, Corbridge, Thomas C, Corbridge
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Journal of Allergy and Clinical Immunology, 2006
Severe asthma represents less than 10% of all asthma, but these patients are responsible for a disproportionate share of the health care costs and morbidity associated with the disease. A significant challenge in the diagnosis and management of severe asthma is the ability to identify accurately the patients most at risk for adverse outcomes, such as ...
Wendy C, Moore, Stephen P, Peters
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Severe asthma represents less than 10% of all asthma, but these patients are responsible for a disproportionate share of the health care costs and morbidity associated with the disease. A significant challenge in the diagnosis and management of severe asthma is the ability to identify accurately the patients most at risk for adverse outcomes, such as ...
Wendy C, Moore, Stephen P, Peters
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American Journal of Respiratory and Critical Care Medicine, 2003
Abstract Acute severe asthma remains a major economic and health burden. The natural history of acute decompensations is one of resolution and only about 0.4% of patients succumb overall. Mortality in medical intensive care units is higher but is less than 3% of hospital admissions.
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Abstract Acute severe asthma remains a major economic and health burden. The natural history of acute decompensations is one of resolution and only about 0.4% of patients succumb overall. Mortality in medical intensive care units is higher but is less than 3% of hospital admissions.
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British Journal of Diseases of the Chest, 1978
Fourteen patients with acute severe asthma necessitating hospital admission were all treated with a standard therapeutic regimen, and in addition received either bromhexine or placebo (initially intravenously and subsequently orally) double-blind. We were unable to show any significant improvement in the rate of recovery of the bromhexine-treated group,
M, Rudolf +4 more
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Fourteen patients with acute severe asthma necessitating hospital admission were all treated with a standard therapeutic regimen, and in addition received either bromhexine or placebo (initially intravenously and subsequently orally) double-blind. We were unable to show any significant improvement in the rate of recovery of the bromhexine-treated group,
M, Rudolf +4 more
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Rhinosinusitis in severe asthma
Journal of Allergy and Clinical Immunology, 2001Chronic rhinosinusitis is a common comorbidity of asthma. However, sinonasal involvement in severe steroid-dependent asthma is still undefined.The aim of the study was to evaluate chronic rhinosinusitis in 35 patients with severe steroid-dependent asthma by using a clinical score and coronal computed tomography (CT) scanning.Thirty-five subjects (16 ...
M, Bresciani +7 more
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