Results 211 to 220 of about 312,536 (265)

Real-World Effectiveness of Tezepelumab in Severe Asthma: A Comparative Analysis of High and Low T2 Phenotypes. [PDF]

open access: yesJ Pers Med
Chiner E   +7 more
europepmc   +1 more source

Phenotypic Clues in Infantile‐Onset Parkinsonism‐Dystonia‐2: A Treatable Neurotransmitter Disorder

open access: yes
Movement Disorders Clinical Practice, EarlyView.
Sangeetha Yoganathan   +10 more
wiley   +1 more source

Severe Asthma in Children

Current Allergy and Asthma Reports, 2017
The aim of this study is to characterize, diagnose, evaluate, and treat severe childhood asthma.Understanding the occurrence of the physiologic and clinical presentations of childhood severe asthma, the treatment and response may be predicted by biomarkers, but the patient's response is highly variable.
Bradley E, Chipps   +2 more
openaire   +4 more sources

Severe Asthma

Clinical Reviews in Allergy & Immunology, 2003
Severe asthma is a term that is commonly used to describe patients with refractory, brittle, near fatal, and difficult-to-control asthma. Patients with severe asthma typically experience persistent symptoms despite medical therapy, report decreased quality of life and suffer an accelerated loss of lung function.
Nicholas J, Kenyon, Nizar N, Jarjour
openaire   +2 more sources

Severe Asthma in Childhood

Immunology and Allergy Clinics of North America, 2019
Severe asthma is broadly defined as asthma requiring a high level of therapy, usually high doses of inhaled corticosteroids, to bring under control. Children who remain symptomatic despite such treatment are a heterogeneous population, and bear a high burden of disease and require high resource utilization.
Angela, Marko, Kristie R, Ross
openaire   +2 more sources

Biologics in severe asthma

Minerva Medica, 2022
Asthma is a chronic airway disease consisting of usually variable airflow limitation and bronchial hyperresponsiveness. Many different phenotypes characterize the clinical expression of asthma, determined by heterogeneous inflammatory patterns driven by distinct cellular and molecular mechanisms known as endotypes.
Pelaia, Corrado   +7 more
openaire   +2 more sources

Severe asthma in children: Evaluation and management

open access: yesAllergology International, 2019
Severe asthma in children is associated with significant morbidity. Children with severe asthma are at increased risk for adverse outcomes including medication-related side effects, life-threatening exacerbations, and impaired quality of life.
Mehtap Haktanir Abul   +1 more
exaly   +3 more sources

Immunopathogenesis of Severe Asthma

Current Pharmaceutical Design, 2011
Severe asthma is a complex heterogeneous disease with substantial unmet clinical need. Understanding the immunopathogenesis is likely to provide insights into potential novel therapies. To date researchers have focussed primarily at a single scale for example genome, cell or whole organ physiology.
Brightling, CE   +4 more
openaire   +3 more sources

Exacerbations of severe asthma

Clinical & Experimental Allergy, 2012
SummaryExacerbations occur frequently in severe asthma. They result in significant morbidity and can lead to hospitalization and death. Severe exacerbations can also lead to an accelerated decline in lung function. Phenotyping severe asthma can aid with both prognostication of exacerbation risk and maintenance treatment selection to minimize future ...
McDonald, V. M., Gibson, P. G.
openaire   +2 more sources

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