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EARLY DIAGNOSIS OF SEVERE COMBINED IMMUNODEFICIENCIES.

Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo, 2017
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Severe Combined Immunodeficiency Disorders

Immunology and Allergy Clinics of North America, 2015
Severe combined immunodeficiency disorders represent pediatric emergencies due to absence of adaptive immune responses to infections. The conditions result from either intrinsic defects in T-cell development (ie, severe combined immunodeficiency disease [SCID]) or congenital athymia (eg, complete DiGeorge anomaly).
Ivan K Chinn, William T Shearer
exaly   +3 more sources

Gene therapy of severe combined immunodeficiencies

The Journal of Gene Medicine, 2001
Recent advances in gene transfer in human hematopoietic cells, combined with a better understanding of the genetic aspects of several immunodeficiencies, has offered new opportunities in the domain of gene therapy. Severe combined immunodeficiency (SCID) appear to represent a good model for the application of gene therapy, combining an expected ...
A, Fischer, S, Hacein-Bey, F, Le Deist, G, De Saint Basile, M, Cavazzana-Calvo   +4 more
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Severe Combined Immunodeficiency Diseases

Springer Seminars in Immunopathology, 1978
The most severe, and also a relatively common immunodeficiency syndrome involves both antibody- and cell-mediated immune mechanisms. In more modern terms the ‘severe combined immunodeficiency’ syndromes (SCID) are defined as all diseases resulting from marked and longlasting functional impairment of both the T- and B-cell system.
W. H. Hitzig, L. J. Dooren, J. M. Vossen
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Advances in the treatment of severe combined immunodeficiency

Clinical Immunology, 2022
Severe Combined Immunodeficiency (SCID) is the most profound inborn error of immunity affecting cellular and humoral immunity. Hematopoietic stem cell transplantation has been a curative treatment since 1968. Huge progress has been made since then in understanding the underlying genetics, improving outcomes from transplant, and introducing gene therapy
Slatter MA, Gennery AR
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A severe combined immunodeficiency mutation in the mouse

Nature, 1983
The most debilitating human lymphoid deficiency disease, known as severe combined immunodeficiency (SCID), impairs the differentiation of both T and B lymphocytes. Affected infants are highly susceptible to recurring infections of viruses, fungi and bacteria and invariably die within 2 yr of birth.
Bosma, G C, Custer, R P, Bosma, M J
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Newborn Screening for Severe Combined Immunodeficiency

Pediatric Clinics of North America, 2019
The T-cell receptor excision circle (TREC) assay is an effective screening tool for severe combined immunodeficiency (SCID). The TREC assay was designed to detect typical SCID and leaky SCID, but any condition causing low naïve T-cell counts will also be detected.
Mohammed, Taki, Tayaba, Miah, Elizabeth, Secord   +2 more
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Chemotactic defects in severe combined immunodeficiency

The Journal of Pediatrics, 1978
Cellular and humoral components of leukotaxis were studied serially in four male infants with severe combined immunodeficiency disease. Two of the four, both lacking B and T cells initially, had a significant defect in neutrophil and monocyte chemotaxis.
S G, Pahwa, E M, Smithwick, E R, Grimes, R J, O'Reilly, R N, Pahwa, R A, Good   +5 more
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