Results 51 to 60 of about 501,602 (328)
DiMA: Sequence Diversity Dynamics Analyser for Viruses [PDF]
arXiv, 2022 Sequence diversity is one of the major challenges in the design of diagnostic, prophylactic and therapeutic interventions against viruses. DiMA is a novel tool that is big data-ready and designed to facilitate the dissection of sequence diversity dynamics for viruses.
arxiv
An in-host model of HIV incorporating latent infection and viral mutation [PDF]
Dynamical Systems, Differential Equations and Applications, AIMS
Proceedings, 2015 pp. 913-922, 2015 We construct a seven-component model of the in-host dynamics of the Human Immunodeficiency Virus Type-1 (i.e, HIV) that accounts for latent infection and the propensity of viral mutation. A dynamical analysis is conducted and a theorem is presented which characterizes the long time behavior of the model.
arxiv +1 more source
Advanced Healthcare Materials, EarlyView.An injectable, adhesive hydrogel integrating 2D‐MoS2 and 5‐fluorouracil (AlgNB/MoS2/5‐FU) is developed for near‐infrared‐triggered photothermal therapy and localized drug delivery. The adhesive hydrogel demonstrates superior tumor anchoring, efficient photothermal conversion, and synergistic inhibition of colorectal cancer progression, offering a ...
Xiaojun Long +8 more
wiley +1 more source
Flow Cytometry Confirmation Post Newborn Screening for SCID in England
International Journal of Neonatal Screening, 2021 An evaluation program for newborn screening for Severe Combined Immunodeficiency began in England in September 2021 based on TREC analysis. Flow cytometry is being used as the follow up diagnostic test for patients with low/absent TRECS.
Kimberly C. Gilmour
doaj +1 more source
Mathematical analysis of an in-host model of viral dynamics with spatial heterogeneity [PDF]
Disc. Cont. Dyn. Sys. B 21: 1237-1257, 2016, 2015 We consider a spatially-heterogeneous generalization of a well-established model for the dynamics of the Human Immunodeficiency Virus-type 1 (HIV) within a susceptible host. The model consists of a nonlinear system of three coupled reaction-diffusion equations with parameters that may vary spatially.
arxiv +1 more source
Advanced Healthcare Materials, EarlyView.Highly sprouting organoid‐like neurovascular spheroids (NVUs) are developed, featuring cell‐loaded poly‐3‐hydroxybutyrate 4‐hydroxybutyrate(P34HB) porous microsphere cores embedded within Gelatin Methacryloyl. NVUs formed complex vascular plexuses and secreted extracellular matrix in vitro, simulating autologous nerves and blood interaction.
Junjin Jie +5 more
wiley +1 more source
Quasispecies dynamics on a network of interacting genotypes and idiotypes: Applications to autoimmunity and immunodeficiency [PDF]
Journal of Statistical Mechanics (2016), 063501, 2015 In spite of their many facets, the phenomena of autoimmunity and immunodeficiency seem to be related to each other through the subtle links connecting retroviral mutation and action to immune response and adaptation. In a previous work, we introduced a network model of how a set of interrelated genotypes (called a quasispecies, in the stationary state)
arxiv +1 more source
Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors
Advanced Therapeutics, EarlyView.Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe +4 more
wiley +1 more source
Clinical and Experimental Dental Research, Volume 8, Issue 6, Page 1354-1375, December 2022., 2022 Abstract Objectives To assess the Candida species occurrence rate and concentration in periodontal pockets in chronic periodontitis (CP) by meta‐analysis. Materials and Methods A search was performed of articles published between January 1, 2010, and October 1, 2020, in English and in Russian, in the electronic databases MEDLINE‐PubMed, Google Scholar,
Ekaterina Slazhneva +5 more
wiley +1 more source
Radiosensitive Severe Combined Immunodeficiency Disease [PDF]
Immunology and Allergy Clinics of North America, 2010 Inherited defects in components of the nonhomologous end-joining DNA repair mechanism produce a T-B-NK+ severe combined immunodeficiency disease (SCID) characterized by heightened sensitivity to ionizing radiation. Patients with the radiosensitive form of SCID may also have increased short- and long-term sensitivity to the alkylator-based chemotherapy ...
Morton J. Cowan, Christopher C. Dvorak
openaire +3 more sources