Results 61 to 70 of about 501,602 (328)
Advanced Science, EarlyView.This study utilized Ss‐STARR‐seq to construct a genome‐wide silencer map of mouse cells and elucidated the fundamental characteristics of these silencers. These silencers exist in a cell‐specific manner and exhibit unique epigenetic modifications. Through functional experiments, we also discovered that these silencers can regulate gene expression and ...
Xiusheng Zhu +12 more
wiley +1 more source
Generation and Characterization of Severe Combined Immunodeficiency Rats
Cell Reports, 2012 Severe combined immunodeficiency (SCID) mice, the most widely used animal model of DNA-PKcs (Prkdc) deficiency, have contributed enormously to our understanding of immunodeficiency, lymphocyte development, and DNA-repair mechanisms, and they are ideal ...
Tomoji Mashimo +18 more
doaj +1 more source
Causal inference with multiple versions of treatment and application to personalized medicine [PDF]
arXiv, 2020 The development of high-throughput sequencing and targeted therapies has led to the emergence of personalized medicine: a patient's molecular profile or the presence of a specific biomarker of drug response will correspond to a treatment recommendation made either by a physician or by a treatment assignment algorithm.
arxiv
Mathematical modeling of escape of HIV from cytotoxic T lymphocyte responses [PDF]
, 2012 Human immunodeficiency virus (HIV-1 or simply HIV) induces a persistent infection, which in the absence of treatment leads to AIDS and death in almost all infected individuals. HIV infection elicits a vigorous immune response starting about 2-3 weeks post infection that can lower the amount of virus in the body, but which cannot eradicate the virus ...
arxiv +1 more source
Advanced Science, EarlyView.This study uses gut microbiome data to predict corticosteroid response in patients with immune thrombocytopenia (ITP). Fecal samples from 212 patients with ITP are sequenced. Six machine‐learning algorithms are used to train predictive models. The support vector machine‐based model integrated clinical data and selected microbial species, diversities ...
Feng‐Qi Liu +38 more
wiley +1 more source
Universal Newborn Screening for Severe Combined Immunodeficiency (SCID)
Frontiers in Pediatrics, 2019 Patients with severe combined immunodeficiency (SCID) are born with profound deficiency of functional T-lymphocytes. Early detection and diagnosis would allow for prompt institution of isolation from infection and referral for definitive treatment with ...
Mirjam van der Burg +5 more
doaj +1 more source
Advanced Science, EarlyView.This study demonstrates that the resveratrol analogue, trans‐4,4′‐dihydroxystilbene (DHS), exhibits synergistic anti‐tumor activity with the PARP inhibitor talazoparib, inducing significant ovarian cancer cell death. The synergistic effect of this combination arises from the concurrent downregulation of homologous recombination factors and the ...
Ganesh Pai Bellare +7 more
wiley +1 more source
CD3ε+ Cells in Pigs With Severe Combined Immunodeficiency Due to Defects in ARTEMIS
Frontiers in Immunology, 2020 Severe combined immunodeficiency (SCID) is described as the lack of functional T and B cells. In some cases, mutant genes encoding proteins involved in the process of VDJ recombination retain partial activity and are classified as hypomorphs. Hypomorphic
Adeline N. Boettcher +15 more
doaj +1 more source
Advanced Science, EarlyView.UniMap introduces a novel multiselective adversarial network that functions as a discerner in single‐cell dataset integration. It enables type‐level integration, ensuring accurate cell type annotation across diverse biological contexts while preserving shared and domain‐specific features.
Haitao Hu +11 more
wiley +1 more source
Frontiers in Immunology, 2020 Pigs with severe combined immunodeficiency (SCID) are an emerging biomedical animal model. Swine are anatomically and physiologically more similar to humans than mice, making them an invaluable tool for preclinical regenerative medicine and cancer ...
Adeline N. Boettcher +26 more
doaj +1 more source