Results 61 to 70 of about 180,819 (342)

LDLR-Gene therapy for familial hypercholesterolaemia: Problems, progress, and perspectives [PDF]

, 2010
Coronary artery diseases (CAD) inflict a heavy economical and social burden on most populations and contribute significantly to their morbidity and mortality rates.
Al-Allaf, FA, Coutelle, C, David, A, Harbottle, R, Themis, M, Waddington, SN   +5 more
core   +3 more sources

Portable Low‐Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aging population of people with HIV (PWH) raises heightened concerns regarding accelerated aging and dementia. Portable, low‐field MRI (LF‐MRI) is an innovative technology that could enhance access and facilitate routine monitoring of PWH.
Annabel Sorby‐Adams, Malachi Keo, Jennifer Guo, Daire Daly, Richard Ahern, Kimon Zachary, Gregory Robbins, Rajesh T. Gandhi, Bragi Sveinsson, Adam de Havenon, Kevin N. Sheth, Otto Rapalino, Juan Eugenio Iglesias Gonzales, W. Taylor Kimberly, Shibani S. Mukerji   +14 more
wiley   +1 more source

Universal Newborn Screening for Severe Combined Immunodeficiency (SCID)

Frontiers in Pediatrics, 2019
Patients with severe combined immunodeficiency (SCID) are born with profound deficiency of functional T-lymphocytes. Early detection and diagnosis would allow for prompt institution of isolation from infection and referral for definitive treatment with ...
Mirjam van der Burg, Nizar Mahlaoui, Hubert Bobby Gaspar, Sung-Yun Pai, Sung-Yun Pai, Sung-Yun Pai   +5 more
doaj   +1 more source

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source

Newborn Screening for Severe Combined Immunodeficiency in Israel

International Journal of Neonatal Screening, 2017
Newborn screening (NBS) programs for severe combined immunodeficiency (SCID), the most severe type of primary immunodeficiency, are being implemented in more and more countries with every passing year.
Erez Rechavi, Atar Lev, Talia Saraf-Levy, Amos Etzioni, Shlomo Almashanu, Raz Somech   +5 more
doaj   +1 more source

Allogeneic and xenogeneic lymphoid reconstitution in a RAG2−/−IL2RGy/− severe combined immunodeficient pig: A preclinical model for intrauterine hematopoietic transplantation

Frontiers in Veterinary Science, 2022
Mice with severe combined immunodeficiency are commonly used as hosts of human cells. Size, longevity, and physiology, however, limit the extent to which immunodeficient mice can model human systems.
Renan B. Sper, Renan B. Sper, Jessica Proctor, Jessica Proctor, Odessa Lascina, Ling Guo, Ling Guo, Kathryn Polkoff, Kathryn Polkoff, Tobias Kaeser, Tobias Kaeser, Sean Simpson, Sean Simpson, Luke Borst, Luke Borst, Katherine Gleason, Katherine Gleason, Xia Zhang, Xia Zhang, Bruce Collins, Bruce Collins, Yanet Murphy, Jeffrey L. Platt, Jorge A. Piedrahita, Jorge A. Piedrahita   +24 more
doaj   +1 more source

What Immunological Defects Predispose to Non-tuberculosis Mycobacterial Infections? [PDF]

, 2017
Nontuberculous mycobacteria (NTM) are categorized as one of the large and diverse groups of environmental organisms which are abundant in water and soil.  NTM cause a variety of diseases in humans that mainly affect the lung.
Adcock, IM, Garssen, J, Kazempour Dizagie, M, Mirsaeidi, M, Moloudizargari, M, Mortaz, E, Movassaghi, M, Varahram, M   +7 more
core  

HIV Types, Groups, Subtypes and Recombinant Forms: Errors in Replication, Selection Pressure and Quasispecies [PDF]

, 2012
HIV-1 is a chimpanzee virus which was transmitted to humans by several zoonotic events resulting in infection with HIV-1 groups M P, and in parallel transmission events from sooty mangabey monkey viruses leading to infections with HIV-2 groups A H.
Alvarez M, Batmanian J, Bocharov G, Brennan CA, Burgard M, Buzon MJ, Dahl V, Dai L, Domingo E, Duarte EA, Etienne L, Fang G, Fultz PN, Gunthard HF, Henriet S, Iordanskiy S, Josef Eberle, Julg B, Kijak GH, Korber B, Law M, Lemey P, Lorenzo-Redondo R, Lutz G. Gürtler, Motomura K, Neel C, Onafuwa-Nuga A, Pathak VK, Pathak VK, Rachinger A, Sauter D, Shimizu N, Simon-Loriere E, Smith DM, Sterjovski J, Swenson LC, Tienen C, Troyer JL, Van der Kuyl AC, Van der Vlist M, Zhu T   +40 more
core   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source