Results 131 to 140 of about 19,116 (219)

Optimizing TREC‐ and KREC‐based newborn screening: Risk‐stratified algorithms significantly reduce referrals

Pediatric Allergy and Immunology, Volume 37, Issue 7, July 2026.
Abstract Background Newborn screening (NBS) quantifying T‐cell receptor excision circles with or without kappa‐deleting recombination excision circles (TREC, KREC) enables early detection of severe T‐ and/or B‐cell lymphopenia. However, both markers have limited specificity, often resulting in unnecessary referrals.
Maarja Soomann, Seraina Prader, Susanna Sluka, Jana Pachlopnik Schmid, Johannes Trück   +4 more
wiley   +1 more source

Treatment strategy for severe combined immunodeficiency in children [PDF]

Background. Severe Combined Immunodeficiency (SCID) is a rare but severe pediatric disease that is marked by a severe deficiency of T and B lymphocytes, which results in a high susceptibility to infections. Objective of the study. The purpose of this
Jayachandran, Jayaraman, Dolapciu, Elena
core  

Transient B cell lymphopenia revealed by KRECs newborn screening: Post‐screening referral strategies, clinical course, and follow‐up

Pediatric Allergy and Immunology, Volume 37, Issue 7, July 2026.
Isolated low KREC and B‐cell lymphopenia in newborns often resolve spontaneously. This multicenter cohort tracked these cases via telemedicine. Repeating KREC testing on a second dry blood spot (DBS) before specialist referral reduces unnecessary immunologic evaluations.
Guarnieri Valentina, Drago Enrico, Pelosi Caterina, Boscia Silvia, Schena Francesca, Traverso Monica, Aloi Concetta, Salina Alessandro, Palmeri Serena, Cassanello Michela, Maghnie Mohamad, Astorino Valeria, Lodi Lorenzo, Azzari Chiara, Volpi Stefano, Ricci Silvia   +15 more
wiley   +1 more source

Corrigendum: A Novel Homozygous JAK3 Mutation Leading to T-B+NK- SCID in Two Brazilian Patients

Frontiers in Pediatrics, 2018
Lucila A. Barreiros, Gesmar R. S. Segundo, Anete S. Grumach, Pérsio Roxo-Júnior, Troy R. Torgerson, Hans D. Ochs, Antonio Condino-Neto   +6 more
doaj   +1 more source

Engraftment of Myasthenia Gravis Thymocytes into Severe Combined Immunodeficiency (SCID) Mice

Autoimmunity, 1998
To study the human immune system, thymocytes from myasthenia gravis (MG) patients were transferred into the peritoneal cavity of severe combined immunodeficiency (SCID) mice, which caused the mice to produce human IgG and IgM. The injected thymocytes were then recovered from the peritoneal cavities of MG-SCID mice. The recovered thymocytes were CD3+ or
openaire   +2 more sources

Development and production of allogeneic cord blood‐derived red blood cell concentrates for transfusion to extremely preterm neonates, the All‐Cord study

Transfusion, Volume 66, Issue 7, Page 1336-1346, July 2026.
Abstract Background Extremely preterm neonates often require red blood cell (RBC) transfusions derived from adult donors. These transfusions introduce adult hemoglobin into a neonatal hematopoietic system dominated by fetal hemoglobin (HbF), shifting the oxygen‐dissociation curve and increasing oxygen delivery to immature tissues.
Jip H. van Daelen, Joyce Bestebroer, Herbert Korsten, Christie Vermeulen, Irwin K. M. Reiss, Enrico Lopriore, Pauline M. Snijder, Elise J. Huisman, Thomas R. L. Klei   +8 more
wiley   +1 more source

A case of severe combined immunodeficiency [PDF]

, 2003
Ağır Kombine ımmün Yetmezlik Sendromu; T ve B lenfositler ile doğal öldürücü hücrelerin gelişim ve fonksiyonlarında bozukluk ile karakterize bir grup hastalığı temsil eder.
Çalkavur, Şebnem, Bak, Mustafa, Nesrin Gülez, Hasan Ağın, Ferah Genel, Gülez, Nesrin, Ağın, Hasan, Şebnem Çalkavur, Yeşim Ergüdenler, Genel, Ferah, Ergüdenler, Yeşim, Mustafa Bak   +11 more
core  

Case Report: Convalescent Plasma Achieves SARS-CoV-2 Viral Clearance in a Patient With Persistently High Viral Replication Over 8 Weeks Due to Severe Combined Immunodeficiency (SCID) and Graft Failure. [PDF]

Front Immunol, 2021
Keitel V, Bode JG, Feldt T, Walker A, Müller L, Kunstein A, Klindt C, Killer A, Senff T, Timm J, Ostermann P, Damagnez M, Lübke N, Adams O, Schaal H, Antoch G, Neubert J, Albrecht P, Meuth S, Elben S, Mohring A, Fischer JC, Bölke E, Hoenig M, Schulz AS, Luedde T, Jensen B.   +26 more
europepmc   +1 more source

Skeletal muscle‐specific myostatin overexpression promotes muscle oxidative capacity and fatigue resistance in transgenic mice

Experimental Physiology, Volume 111, Issue 7, Page 3357-3380, 1 July 2026.
Abstract In addition to controlling muscle mass, myostatin may support oxidative metabolism and endurance. Loss of function through gene knockout or post‐natal blockade generally lowers muscle oxidative capacity and increases fatigability. These observations imply that myostatin activation could promote a more oxidative and less fatigable muscle ...
Andy V. Khamoui, Andrea Abraham, Janos Porszasz, Istvan Kovanecz, Silvana Constantinescu, Harry B. Rossiter, Suzanne Reisz‐Porszasz   +6 more
wiley   +1 more source

Exercise training prior to and during cancer in mice preserves muscle mass, reduces tumour weight and suppresses molecular mediators of cachexia

The Journal of Physiology, Volume 604, Issue 14, Page 6028-6056, 15 July 2026.
Abstract figure legend PoWeR training (11.5 weeks of voluntary wheel running with progressively increased resistance) before and during cancer attenuates muscle loss, limits tumour growth, drives a transition toward a more oxidative muscle phenotype (IIB‐to‐IIA shift), downregulates cachexia‐associated pathways and enhances mitochondrial performance in
Stavroula Tsitkanou, Pieter J. Koopmans, Ana Regina Cabrera, Nathan Serrano, Calvin S. Peterson, Ruqaiza Muhyudin, Zain B. Malik, Micah Goeke, Eleanor R. Schrems, Francielly Morena, Yuan Wen, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene   +13 more
wiley   +1 more source