Results 111 to 120 of about 19,116 (219)

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1310-1324, July 2026.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Newborn screening for severe combined immunodeficiency: breaking the bubble [PDF]

, 2022
Severe combined immunodeficiency (SCID) is one of the most severe form of inborn errors of immunity characterized by the absence or dysfunction of T-lymphocytes affecting both cellular and humoral immunity.
Blom, M.
core   +1 more source

A Review of Primary Immune Deficiency Disorders

European Medical Journal Allergy & Immunology, 2020
This scenario-based review of primary immunodeficiency diseases (PIDD) discusses the differential diagnosis, usual presentations, work-up, and treatment of children with the most commonly encountered immune disorders.
Talin Darian, Joudeh B. Freij, Divya Seth, Pavadee Poowuttikul, Elizabeth Secord   +4 more
doaj  

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, Volume 2, Issue 3, July 2026.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Caecal Epithelium‐Derived Thymic Stromal Lymphopoietin is not Required for Protective Immunity Against Whipworm

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Immunity to Trichuris muris infection is unimpacted by epithelial knockout of TSLP expression. Imaging of transcription in the caecum reveals Tslp transcription throughout infection in EpCAM‐, Foxl1‐, Ccl24‐ lamina propria‐resident cells, contributing during the expulsion phase of infection. ABSTRACT Recent research examining classical type two alarmin
Connor P. Lynch, Seona Thompson, Erin‐Claire Pallott, Laura Campbell, Sang Hun Lee, Richard K. Grencis   +5 more
wiley   +1 more source

Newborn Screening for Primary Immunodeficiencies: Focus on Severe Combined Immunodeficiency (SCID) and Other Severe T-Cell Lymphopenias [PDF]

, 2015
Primary immunodeficiencies (PID) are congenital disorders of immune competence, which are mainly characterized by a pathological susceptibility to infection.
Janine Reichenbach, Stephan Borte
core   +1 more source

Metabolome analysis identified exogenous cholesterol within lipid rafts that activate the Akt/mTOR signaling pathway in epithelial ovarian cancer

International Journal of Cancer, Volume 159, Issue 1, Page 257-268, 1 July 2026.
What's New? Epithelial ovarian cancer (EOC) is a severe malignancy with few effective treatment options. While the mechanisms remain unclear, changes in lipid metabolism may fuel tumor growth and EOC progression, offering a possible path for new treatments.
Hitomi Sakaguchi‐Mukaida, Kosuke Hiramatsu, Tatsuo Masuda, Mamoru Kakuda, Satoshi Nakagawa, Tadashi Iwamiya, Shinya Matsuzaki, Tetsuji Naka, Yutaka Ueda, Tadashi Kimura, Michiko Kodama   +10 more
wiley   +1 more source

Expectations and experience: Parent and patient perspectives regarding treatment for Severe Combined Immunodeficiency (SCID). [PDF]

Clin Immunol, 2021
Smith H, Scalchunes C, Cowan MJ, Puck J, Heimall J.   +4 more
europepmc   +1 more source

From hidden immunodeficiency to hyperinflammatory crisis: Cryptococcosis-induced HLH in adult-onset severe combined immunodeficiency

Indian Journal of Pathology and Microbiology
Severe combined immunodeficiency (SCID) is classically a pediatric disease, yet rare late-onset forms can present in adulthood with atypical infections.
O P Muhammed Yaseen, Sarika Singh, Kajol Rana, Daksha Suthar, Meeta Singh, Priya Suneja, Sumeet Singla, Samagra Singh   +7 more
doaj   +1 more source

Immune Dysregulation in Branched Chain Organic Acidemias

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Organic acidemias (OAs) are a group of inherited disorders, most commonly caused by defects in mitochondrial enzymes involved in amino acid and fatty acid metabolism. While they characteristically present with metabolic and neurological crises, growing evidence reveals a significant burden of chronic immune dysregulation in some disorders and ...
Abdul L. Shakerdi, Jack Drda, Justin A. Dutta, Jerry Vockley   +3 more
wiley   +1 more source