Results 91 to 100 of about 19,116 (219)

Physapubescin B From Physalis: A Food‐Derived Withanolide for Cancer Chemoprevention and Nutraceutical Development

eFood, Volume 7, Issue 4, August 2026.
Physapubescin B may interfere with multiple cancer‐associated signaling pathways by inhibiting Ras/Raf/mitogen‐activated protein kinase kinase/extracellular signal‐regulated kinase (Ras/Raf/MEK/ERK) signaling and vascular endothelial growth factor (VEGF)‐dependent angiogenesis.
Wojciech Koch, Katarzyna Stępnik, Anna Wawruszak, Estera Okoń, Agata Jarząb, Katarzyna Gaweł‐Bęben, Magdalena Michalak‐Tomczyk, Jacek Jachuła, Magdalena Zdziebło, Paweł Helon, Javad Sharifi‐Rad, Daniela Calina   +11 more
wiley   +1 more source

BCL‐2 and MCL1 co‐inhibition enhances glucocorticoid therapy in preclinical models of infant KMT2A‐rearranged acute lymphoblastic leukaemia

British Journal of Haematology, EarlyView.
Mawar Karsa, Ayu Karsa, Dayna Spurling, Lin Xiao, Emma Ronca, Angelika Bongers, Weiman Gao, Andrew J. Gifford, Ali El‐Ayoubi, Laurence C. Cheung, Rishi S. Kotecha, Richard B. Lock, Charis E. Teh, Guillaume Lessene, Murray D. Norris, Andrew Wei, Michelle Haber, Michelle J. Henderson, Donia M. Moujalled, Klaartje Somers   +19 more
wiley   +1 more source

Sphingosine‐1‐Phosphate Receptor 1 Promotes Ovarian Cancer Tumorsphere Proliferation and Metastasis

International Journal of Cancer, Volume 159, Issue 3, Page 768-781, 1 August 2026.
In high‐grade serous ovarian cancer, malignant ascites frequently arise as ovarian cancer cells shed from the primary tumor and aggregate into tumorspheres, severely limiting treatment success. To date, little is known about the mechanisms governing tumorsphere endurance and metastasis within the ascites once formed.
Núria Gendrau‐Sanclemente, Agnès Figueras, Ferran Medina‐Jover, Juan A. Marín‐Jiménez, Michelle De Leeuw, Tianyu Dai, Marina Moreno‐Mosquera, Andrea Morales, Marc Guiu, Josefina Casas, José Carlos Perales, Roger R. Gomis, Francesc Viñals   +12 more
wiley   +1 more source

The severe combined immunodeficient (SCID) mouse as a model for the study of autoimmune diseases [PDF]

Clinical and Experimental Immunology, 1993
SUMMARYThere are no readily available in vivo models to study immune cells from humans with autoimmune diseases. SCID mice, which virtually lack both T and B lymphocytes and accept xenogeneic cells, have been used during the last 5 years to provide a milieu for lymphocytes isolated from individuals with various autoimmune diseases, or for lymphocytes ...
openaire   +2 more sources

Targeting the NAT1‐ENO1‐Lactate Axis Destabilizes PD‐L1 to Reinvigorate Antitumor Immunity in Colorectal Cancer

MedComm, Volume 7, Issue 8, August 2026.
NAT1 downregulates PD‐L1 protein expression by acetylating ENO1, which inhibits lactate‐fueled TRAF6/PD‐L1 signaling (left). Conversely, NAT1 deficiency in CRC cells enhances ENO1 activation, leading to increased glycolysis and lactate production. The lactate then binds to TRAF6, promoting its oligomerization and activation.
Yi‐Xuan Liu, Wen‐Xin Wu, Yang Zang, Guang Hu, Xin Guo, Yi Wang, Yun Yang, Zhi Jiang, Xiu‐Ming Li, Feng Liu, Yue‐Yue Wu, Zu‐Da Pan, Yuan‐Meng Hu, Ruo‐Yang Zhang, Hai‐Yi Zhang, Ping‐An Chang, Xiao‐Shun He, Wen‐Juan Gan, Hua Wu   +18 more
wiley   +1 more source

Severe combined immunodeficiency (SCID) presenting in childhood, with agammaglobulinemia, associated with novel compound heterozygous mutations in DCLRE1C [PDF]

, 2019
Severe combined immunodeficiency (SCID) can be caused by deleterious mutations in DCLRE1C, leading to deficient non-homologous end joining by compromising the function of the Artemis protein.
Nilsson, Jakob; https://orcid.org/, Marits, Per, Ramme, Kim, Kolios, Antonios G A, Sundin, Mikael   +4 more
core   +1 more source

IL2RG hypomorphic mutation: identification of a novel pathogenic mutation in exon 8 and a review of the literature

Allergy, Asthma & Clinical Immunology, 2019
Background Atypical X-linked severe combined immunodeficiency (X-SCID) is a variant of cellular immunodeficiency due to hypomorphic mutations in the interleukin 2 receptor gamma (IL2RG) gene.
Che Kang Lim, Hassan Abolhassani, Sofia K. Appelberg, Mikael Sundin, Lennart Hammarström   +4 more
doaj   +1 more source

Development of Chimeric Antigen Receptor‐Modified NK Cells for the Immunotherapy of Adult T‐Cell Leukemia/Lymphoma

European Journal of Haematology, Volume 117, Issue 2, Page 481-491, August 2026.
ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive hematological malignancy with a poor prognosis and limited therapeutic options. ATL cells exhibit aberrant surface glycosylation patterns resulting from dysregulated glycosyltransferase expression, representing a potentially tumor‐specific therapeutic target.
Yuichiro Uchida, Seigo Tateo, Masahiro Wakao, Hiroyuki Shinchi, Hayate Sawayama, Akira Fukumoto, Makoto Yoshimitsu, Yasuo Suda   +7 more
wiley   +1 more source

Diagnosis of severe combined immunodeficiency [PDF]

Early diagnosis of severe combined immunodeficiency (SCID) is important to enable prompt referral to a supraregional centre for bone marrow transplantation before the occurrence of end organ damage secondary to infective complications.
Gennery AR, Cant AJ
core  

Dendritic cell‐specific hypoxia‐inducible factor‐1α deficiency protects mice from recurrent retroviral infection

Experimental Physiology, Volume 111, Issue 8, Page 3843-3856, 1 August 2026.
Abstract Antigen‐processing and ‐presenting cells play a pivotal role in initiation of the antiviral immune response. The cellular adaption of dendritic cells to reduced oxygen and nutrition levels at the site of infection is regulated predominantly by the transcription factor complex hypoxia‐inducible factor‐1 (HIF‐1).
Timm Schreiber, Yvonne Hüsecken, Claudia Lodewick, Simone Schimmer, Gennadiy Zelinskyy, Ulf Dittmer, Kathrin Sutter, Joachim Fandrey, Sandra Winning   +8 more
wiley   +1 more source