Results 71 to 80 of about 3,431,364 (275)

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

On the dynamics of a class of multi-group models for vector-borne diseases [PDF]

, 2015
The resurgence of vector-borne diseases is an increasing public health concern, and there is a need for a better understanding of their dynamics. For a number of diseases, e.g.
Aberrahman Iggidr, Gauthier Sallet, Max, O. Souza   +3 more
core   +5 more sources

Assessing the risk of dengue severity using demographic information and laboratory test results with machine learning.

PLoS Neglected Tropical Diseases, 2020
BackgroundDengue virus causes a wide spectrum of disease, which ranges from subclinical disease to severe dengue shock syndrome. However, estimating the risk of severe outcomes using clinical presentation or laboratory test results for rapid patient ...
Sheng-Wen Huang, Huey-Pin Tsai, Su-Jhen Hung, Wen-Chien Ko, Jen-Ren Wang   +4 more
doaj   +1 more source

Perbandingan Tingkat Keparahan Infeksi Sekunder Virus Dengue pada Keempat Serotipe di Indonesia: Systematic Review

Jurnal Kesehatan Andalas, 2021
Secondary infection with the dengue virus causes mild to severe manifestations. The distribution of dengue virus serotypes varies in various areas and can change over time.
Annelin Kurniati, Ahmad Fandi, Mardhatillah Sariyanti, Ety Febrianti, Debie Rizqoh   +4 more
doaj   +1 more source

Hyperlipidemia, statin use and dengue severity [PDF]

Scientific Reports, 2018
AbstractMultiple in vitro and mice model studies suggest statins may attenuate dengue severity. However, little is known about statin use and dengue severity in adult dengue patients with hyperlipidemia. We conducted a retrospective cohort study from 2004–2008 and 2012–2013 in Tan Tock Seng Hospital, Singapore on adult dengue patients with ...
Po Ying Chia, Htet Lin Htun, Wei Ping Ling, Yee Sin Leo, Tsin Wen Yeo, David Chien Boon Lye   +5 more
openaire   +3 more sources

Inhaled Angiopoietin‐Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis

Advanced Science, EarlyView.
Inhaled antisense oligonucleotides targeting ANGPTL4 attenuate inflammation, preserve barrier integrity, and reduce fibrosis in both infectious and sterile lung injury models. Integrated transcriptomic analysis reveals a conserved ANGPTL4‐regulated gene network coordinating hypoxic, inflammatory, apoptotic, and stress‐response pathways.
Haiyang Fan, Yuanyang Tan, Junhang Zhang, Xiaoya Liu, Jing Qu, Damien Chua, Hong Sheng Cheng, Joseph Han Sol Kim, Yu Xuan Liu, Changfei Qin, Yingzi Liu, Dezhi Li, Jikang Qiu, Mengshi Chi, Mingmin Bi, Qiwei Zhang, Yun Li, Masoumeh Motamedi Joibari, Stefan K Nilsson, Nguan Soon Tan, Yunping Fan, Liang Li   +21 more
wiley   +1 more source

Dengue NS1 Kinetics and its Utility as a Predictor of Severe Dengue Disease: An Ambispective Study

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Background: Dengue is a febrile illness with varied clinical manifestations. The disease manifestations can vary from an asymptomatic infection to a severe infection with multiorgan dysfunction.
Puneet Bhatt, Muralidhar Varma, Chiranjay Mukhopadhyay   +2 more
doaj   +1 more source

Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients

Scientific Reports, 2020
Dengue induces a spectrum of severity in humans from the milder dengue fever to severe disease, or dengue hemorrhagic fever (DHF). Chymase is a candidate biomarker that may aid dengue prognosis.
Abhay P. S. Rathore, M. Senanayake, A. Athapathu, S. Gunasena, Irantha Karunaratna, W. Leong, Ting Lim, C. Mantri, A. Wilder-Smith, A. S. St. John   +9 more
semanticscholar   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Dengue Infection Complicated by Hemophagocytic Lymphohistiocytosis: Experiences From 180 Patients With Severe Dengue

Clinical Infectious Diseases, 2019
Background Globally, ~500 000 people with severe dengue (SD) require hospitalization yearly; ~12 500 (2.5%) die. Secondary hemophagocytic lymphohistiocytosis (sHLH) is a potentially fatal hyperinflammatory condition for which HLH-directed therapy (as ...
F. K. Kan, Cheng Cheng Tan, Tatiana von Bahr Greenwood, K. Khalid, Premaa Supramaniam, Ida Hed Myrberg, L. Tan, J. Henter   +7 more
semanticscholar   +1 more source