Results 81 to 90 of about 3,431,364 (275)

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

A comparison of WHO guidelines issued in 1997 and 2009 for dengue fever - single centre experience. [PDF]

, 2013
Objective: To compare the original (1997) and revised (2009) versions of World Health Organization guidelines for dengue patientsMethods: Adult patients with a positive dengue Immunoglobulin M serology, and a diagnosis of dengue were included in the ...
Ejaz, Kiran, Fayyaz, Jabeen, Khan, Uzma R., Khursheed, Munawar, Qamar, Irum, Razzak, J.   +5 more
core   +1 more source

Understanding immunopathology of severe dengue: lessons learnt from sepsis.

Current Opinion in Virology, 2020
Endothelial dysfunction leading to vascular permeability and plasma leakage are characteristic features of severe dengue and sepsis. However, the mechanisms underlying these immune-pathologies remain unclear.
J. A. Aguilar-Briseño, Jill Moser, Izabela A. Rodenhuis-Zybert   +2 more
semanticscholar   +1 more source

Immunomodulation in dengue: towards deciphering dengue severity markers

Cell Communication and Signaling
Dengue is a vector-borne debilitating disease that is manifested as mild dengue fever, dengue with warning signs, and severe dengue. Dengue infection provokes a collective immune response; in particular, the innate immune response plays a key role in primary infection and adaptive immunity during secondary infection.
Manoj Kumar Dash, Sagnika Samal, Shailesh Rout, Chinmay Kumar Behera, Mahesh Chandra Sahu, Biswadeep Das   +5 more
openaire   +3 more sources

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Peroxidase‐Mimicking Nanozymes for Rapid Detection of Infectious Diseases

Advanced Science, EarlyView.
Peroxidase‐mimicking nanozymes (PMNs) have emerged as robust and versatile materials for rapid infectious disease diagnostics. This review highlights the rational design and controlled synthesis of PMNs, summarizes key biomarkers relevant to infectious diseases, examines their integration into diverse rapid detection platforms, and highlights ...
Shikuan Shao, Victor Fernandez‐Gonzalez, Xiaochuan Wang, Blake Pylipow, Claudia Herrera, Xiaohu Xia   +5 more
wiley   +1 more source

Comparison of Two Detailed Models of Aedes aegypti Population Dynamics [PDF]

, 2016
The success of control programs for mosquito-­borne diseases can be enhanced by crucial information provided by models of the mosquito populations.
Arrivillaga J., Ekpereonne E., Focks D. A., Gilpin M. E., Horsfall W. R., Naksathit A. T., Peirce C. S., Southwood T. R. E., WHO, WHO   +9 more
core   +1 more source

Variables epidemiológicas en pacientes con sospecha de dengue

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2016
Fundamento: no se avizora la desaparición a corto plazo de los factores que favorecen la diseminación del Aedes aegypti y el incremento en la circulación del virus del dengue. A finales del año 2013 fue abierto un hospital de campaña en Las Tunas, debido
Sarah María Regueira Betancourt, Manuel de Jesús Díaz Pérez, Pabel Boris Peña Enamorado   +2 more
doaj  

Virus-inclusive single-cell RNA sequencing reveals the molecular signature of progression to severe dengue

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance A fraction of the 400 million people infected with dengue annually progresses to severe dengue (SD). Yet, there are currently no biomarkers to predict disease progression.
F. Zanini, Makeda L. Robinson, Derek Croote, M. Sahoo, A. Sanz, Eliana Ortiz-Lasso, Ludwig L Albornoz, F. Rosso, J. Montoya, Leslie Goo, B. Pinsky, S. Quake, S. Einav   +12 more
semanticscholar   +1 more source

Machine Learning‐Assisted Infectious Disease Detection in Low‐Income Areas: Toward Rapid Triage of Dengue and Zika Virus Using Open‐Source Hardware

Advanced Intelligent Discovery, EarlyView.
This study introduces an affordable machine learning platform for simultaneous dengue and zika detection using fluorine‐doped tin oxide thin films modified with gold nanoparticles and DNA aptamers. Designed for low‐cost, hardware‐limited devices (< $25), the model achieves 95.3% accuracy and uses only 9.4 kB of RAM, demonstrating viability for resource‐
Marina Ribeiro Batistuti Sawazaki, Bassam Bachour Junior, Marcelo Mulato, José Ilton de Oliveira Filho   +3 more
wiley   +1 more source