Results 161 to 170 of about 327,068 (394)

When sequential use of mepolizumab and dupilumab in a severe atopic eosinophilic asthmatic questions the role of eosinophils in mediating the clinical expression of the disease: a case report

Journal of Medical Case Reports
Background The advent of biologics has resulted in major progress in the treatment of severe T2 high asthmatics. There are currently several classes of biologics approved for severe asthma including anti-immunoglobulin E, anti-interleukin-5/interleukin ...
M. Sabbe, F. Schleich, P. Janssens, R. Louis   +3 more
doaj   +1 more source

Pediatric hospitalizations associated with respiratory syncytial virus (RSV) and influenza, and the frequency of asthma as a secondary diagnosis [PDF]

arXiv, 2017
Background: There is uncertainty about the burden of severe outcomes associated with RSV and influenza in children. Methods: We have applied previously developed methodology to estimate the rates of influenza and RSV-associated hospitalizations with different diagnoses in different age subgroups of US children between the 2003-04 through the 2009-10 ...
arxiv  

Heterogeneity of phenotypes in severe asthmatics. The Belgian Severe Asthma Registry (BSAR). [PDF]

, 2014
The Belgian severe asthma registry is a web-based registry encompassing demographic, clinical, functional and inflammatory data of severe asthmatics (SA), aiming at improving awareness, knowledge on its natural history and subphenotypes, and offering ...
Brusselle, G., Joos, G., Louis, Renaud, Manise, Maïté, Michils, A., Peche, R., Pilette, C., SCHLEICH, FLorence, Vandenplas, O.   +8 more
core   +1 more source

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Med Research, EarlyView.
ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li, Yuxuan Wan, Alan Jiao, Ke Jiang, Gaoyuan Cui, Jinxin Tang, Simin Yu, Zhengang Hu, Songfeng Zhao, Zhenjie Yi, Lifu Long, Yang Yang, Xuehao Cui, Chunrun Qu   +13 more
wiley   +1 more source

Post‐COVID‐19 condition: clinical phenotypes, pathophysiological mechanisms, pathology, and management strategies

The Journal of Pathology, EarlyView.
Abstract Post‐COVID‐19 condition (PCC), also known as long COVID, is a complex multiple organ system condition that can develop and persist for months after acute COVID‐19. PCC encompasses a wide range of symptoms, resulting in heterogeneous clinical manifestations. These manifestations likely arise from diverse underlying pathophysiological mechanisms,
Larissa E Vlaming‐van Eijk, Guolu Tang, Arno R Bourgonje, Wilfred FA den Dunnen, Jan‐Luuk Hillebrands, Harry van Goor   +5 more
wiley   +1 more source

Measuring the Impact of Urban Street Trees on Air Quality and Respiratory Illness [PDF]

arXiv, 2017
New streams of data enable us to associate physical objects with rich multi-dimensional data on the urban environment. This study presents how open data integration can contribute to deeper insights into urban ecology. We analyze street trees in New York City (NYC) with cross-domain data integration methods by combining crowd-sourced tree census data -
arxiv  

Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis. [PDF]

, 2017
The epithelial and epidermal innate cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) have pivotal roles in the initiation of allergic inflammation in asthma and atopic dermatitis (AD).
Cheng, D, Di, H, Erle, DJ, Huo, X, Mo, Y, Shi, H, Xu, Y, Yi, L, Zhang, H, Zhang, K, Zhao, J, Zhen, G, Zou, Y   +12 more
core   +1 more source

CXCL14 increase dendritic cell antigen presentation and promote asthma immune response

Pediatric Discovery, EarlyView.
RNA‐seq showed that C‐X‐C motif chemokine ligand 14 (CXCL14) was upregulated in bone marrow dendritic cells after house dust mites (HDM) stimulation, and its function was related to signal molecule interaction and the immune system. The expression of CXCL14 was increased in the HDM‐induced allergic asthma model.
Wenjie Wu, Fengxia Ding, Yan Li, Zhou Fu
wiley   +1 more source

High-throughput screening for modulators of cellular contractile force [PDF]

arXiv, 2014
When cellular contractile forces are central to pathophysiology, these forces comprise a logical target of therapy. Nevertheless, existing high-throughput screens are limited to upstream signaling intermediates with poorly defined relationship to such a physiological endpoint.
arxiv  

Head and Neck Manifestations of Eosinophilic Granulomatosis with Polyangiitis: A Systematic Review. [PDF]

, 2016
OBJECTIVE: To conduct the first and only systematic review of the existing literature on head and neck manifestations of eosinophilic granulomatosis with polyangiitis to guide clinical decision making for the otolaryngologist.
Basnyat, Shristi, Goldfarb, Jared M., Nyquist, Gurston G., Rabinowitz, Mindy R., Rosen, Marc R.   +4 more
core   +1 more source