Results 141 to 150 of about 1,917,601 (292)

Mapping Allergen B‐ and T‐Cell Epitopes: Technological Advances and Their Role in Precision Allergy Therapy

Allergy, EarlyView.
ABSTRACT Allergic diseases arise from aberrant immune recognition of otherwise harmless environmental proteins and are driven by epitope‐specific interactions between allergens and the adaptive immune system. Although component‐resolved diagnostics have improved molecular characterisation of sensitization, they remain limited to whole‐allergen ...
Mark Møiniche, Josefine Corneliussen, Kristoffer H. Johansen, Alexandre Ruiz‐Carrasco, Caroline Paulsen, Yuchen Li, Carolina Barra, Sandhya Bangaru, Monica L. Fernández‐Quintero, Ewa Bartko, Lars Blom, Esperanza Rivera‐de‐Torre   +11 more
wiley   +1 more source

Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions

Allergy, EarlyView.
Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira, Lisa Holla, Sophia Björkander, Marie Kaarup Bek, Lorenz Wirth, Patrick A. Shearer, Jesper Säfholm, Erik Sachs, Mamdoh Al‐Ameri, Kasra Vali, Sandra Ekström, Erik Melén, Jenny Mjösberg, Christopher Andrew Tibbitt   +13 more
wiley   +1 more source

COVID-19, Eosinophils, and Biologicals for Severe Asthma

Frontiers in Allergy, 2022
Lombardi, Carlo, Bagnasco, Diego, Passalacqua, Giovanni   +2 more
openaire   +3 more sources

Efficacy and Safety of Dupilumab in Chinese Adult Patients With Chronic Rhinosinusitis With Nasal Polyps: A Randomized, Placebo‐Controlled, Phase III Trial

Allergy, EarlyView.
Dupilumab significantly improved nasal polyp score, nasal congestion, olfaction, total symptom score, and disease‐specific quality of life in Chinese patients with uncontrolled CRSwNP. Incidence of treatment‐emergent adverse events was similar between dupilumab and placebo.
Mu Xian, Menglin Wang, Changqing Zhao, Lijia Wan, Yu Xu, Juan Meng, Rui Xu, Xicheng Song, Li Shi, Yucheng Yang, Yan Jiang, Yanzhen Wu, Bethany Ling, Vivian Li, Andrew P. Fontenot, Lacey R. Robinson, Neelam A. Phadke, Chengshuo Wang, Luo Zhang   +18 more
wiley   +1 more source

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

Deficiency of Mitochondrial Fatty Acid Enzyme, CPT1A, Underlies Airway Epithelial Barrier Dysfunction in Severe Asthma

Allergy, EarlyView.
Mitochondrial fatty acid enzyme, CPT1A, is deficient in the airway epithelium of severe asthma patients. Restoration of CPT1A expression improved epithelial barrier integrity via increasing mitochondrial respiration and ATP production in airway epithelial cells. Restoration of deficient epithelial CPT1A may represent a new treatment approach for severe
Muyun Wang, Haiyang Hu, Kun Wang, Di Wu, Ximing Liao, Jing Gao, Tian Li, Wujian Xu, Shaoyong Gao, Qiang Li, Pankaj Kumar Bhavsar, Wei Gao, Kian Fan Chung   +12 more
wiley   +1 more source

Benralizumab: a unique IL-5 inhibitor for severe asthma

, 2016
Laren D Tan,1 Jennifer M Bratt,2 Dorottya Godor,3 Samuel Louie,2 Nicholas J Kenyon2 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, School of Medicine, Loma Linda University, Loma Linda, CA, USA; 2Division of Pulmonary,
Kenyon NJ, Bratt JM, Louie S, Tan LD, Godor D   +4 more
core  

Development of Nummular Dermatitis Following Dupilumab Therapy Suggests a Th17‐Driven Mechanism

Australasian Journal of Dermatology, EarlyView.
Olga Pawlik, Michelle McRae
wiley   +1 more source

Efficacy of Full and Limited Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps: A Randomised Controlled Trial

Allergy, EarlyView.
Both Full and Limited FESS result in clinically meaningful relief of disease‐specific HRQoL and nasal breathing, effectively improving nasal symptoms and sleep disturbance in CRSwNP patients. Clinically meaningful difference in decrease of SNOT‐22 scores between the groups was not found at 12‐ and 24–month follow‐up.
P. Virkkula, S. Hammarén‐Malmi, A. Laulajainen‐Hongisto, M. Lilja, J. Wikstén, L. Hafrén, P. Kauppi, S. Reitsma, K. Pajala, J. Sahlman, S. Toppila‐Salmi   +10 more
wiley   +1 more source

Benralizumab in Severe Eosinophilic Asthma: Toward Disease Control and Evolving Treatment Paradigms. [PDF]

J Inflamm Res
Maglio A, Vitale C, D'Auria LO, Longobardi V, Franzese A, Pelaia C, Pelaia G, Calabrese C, Vatrella A.   +8 more
europepmc   +1 more source