Results 161 to 170 of about 37,820 (304)

Predictive Factors And Treatments Associated with Clinical Remission in Severe Eosinophilic Asthma. [PDF]

J Inflamm Res
Lupia C, Marchi G, Chiarella E, Piazzetta GL, Lobello N, Crimi C, Poto R, Maglio A, Vatrella A, Pelaia G, Pelaia C.   +10 more
europepmc   +1 more source

Early Risk Assessment and Recognition of Allergies in Children: Rationale, Methodology, and Proposed Algorithms

Allergy, EarlyView.
ABSTRACT Background Atopic diseases—including atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR), and asthma—are the most common chronic conditions in childhood and adolescence, affecting up to 30% of the global population. In Germany alone, more than 2.1 million children and adolescents are affected.
E. Hamelmann, B. Schaub, K. Beyer, K. Blümchen, M. Gerstlauer, M. V. Kopp, L. Lange, S. Lau, N. Maison, H. Ott, S. M. Schmidt, T. Spindler, C. Traidl‐Hoffmann, C. Vogelberg   +13 more
wiley   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Comparative efficacy of mepolizumab and benralizumab in severe eosinophilic asthma: a retrospective cohort study. [PDF]

BMC Pulm Med
Huang WC, Shen YL, Cheng WC, Huang CW, Chen CH, Tu CY, Hsu WH.   +6 more
europepmc   +1 more source

COVID-19, Eosinophils, and Biologicals for Severe Asthma

Frontiers in Allergy, 2022
Lombardi, Carlo, Bagnasco, Diego, Passalacqua, Giovanni   +2 more
openaire   +3 more sources

Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells

Allergy, EarlyView.
We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller, Julia Hambach, Alessa Zoe Schaffrath, Thomas Eden, Sophia Cichutek, Anna Josephine Gebhardt, Natalie Tode, Ronald Maitschke‐Rajasekharan, Philipp Lewe, Sharon Qi, Susanne Witt, Marie Eggers, Nicola M. Tomas, Friedrich Haag, Friedrich Koch‐Nolte, Boris Fehse, Kristoffer Riecken   +16 more
wiley   +1 more source

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Allergy, EarlyView.
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery, Rüçhan Ekren, Emilie Bérard, Aurélie Du‐Thanh, Hugo Rimet, Fatma Jendoubi, Vanina Lenief, Nadia Raison‐Peyron, Amel Bouznad, Maria P. Konstantinou, Jonathan Rioual, Lilian Basso, Juliette Mouiren, Manon Boussier, Brigitte Milpied, Cristina Bulai Livideanu, Louise Jaulent, Florence Hacard, Marine A. Lefevre, Audrey Nosbaum, Julien Seneschal, Marc Vocanson, Carle Paul, Nicolas Gaudenzio, Marie Tauber, on behalf of the French Atopic Dermatitis Network from de GREAT Research group   +25 more
wiley   +1 more source

Characteristics of Patients with Severe Uncontrolled Asthma in Saudi Arabia: A Cross-Sectional Study

Journal of Asthma and Allergy
Riyad O Al-Lehebi,1,2 Rana A Saleh,3 Abdalla M Alasiri,4 Bader J Alghamdi,5,6 Hajer Y Almudaiheem,7,8 Ahmed H Al-jedai,8,9 Eid A Almutairi,3 Haifa Aldakhil,10 Khaulah A Alokili,7 Fahad Zuriqan,7 Adeeb A Bulkhi11 1Pulmonary Department, King Fahad Medical ...
Al-Lehebi RO, Saleh RA, Alasiri AM, Alghamdi BJ, Almudaiheem HY, Al-jedai AH, Almutairi EA, Aldakhil H, Alokili KA, Zuriqan F, Bulkhi AA   +10 more
doaj  

Mepolizumab treatment alters the functional phenotype of eosinophils in severe eosinophilic asthma. [PDF]

Front Immunol
Miguéns-Suárez P, Martelo-Vidal L, Vázquez-Mera S, Blanco-Aparicio M, Calvo-Álvarez U, González-Fernández C, Mosteiro-Añón M, Corbacho-Abelaira D, Hermida-Valverde T, Calvo-Henríquez C, Nieto-Fontarigo JJ, Salgado FJ, González-Barcala FJ.   +12 more
europepmc   +1 more source

Emerging Risk: Intranasal Tin Exacerbates Allergic Rhinitis in Humans and Mice

Allergy, EarlyView.
Delgama A. S. M. Nishadhi, Shogo Sumiya, Akira Tazaki, Takumi Kagawa, Mohamed Abdelmoneim, Masafumi Sakashita, Kazuhiro Ogi, Shigeharu Fujieda, Shinichi Iwasaki, Masashi Kato   +9 more
wiley   +1 more source