Results 121 to 130 of about 37,820 (304)

Potential Biomarkers for Disease Stratification and Prognosis Prediction in Pediatric Asthma: LCN2, sST2 and FGF21

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pediatric asthma is a common chronic airway inflammatory disease, where accurate assessment of disease severity and prognosis prediction is crucial for treatment decisions. Currently, there is a lack of precise and effective biomarkers.
Xu Yang, Hai Wang, Yong‐Zheng Zhang, Yan‐Yan Chen, Xin‐Xin Xing, Yi‐Cheng Ding   +5 more
wiley   +1 more source

Olfactory Bulb Volume and Function Recovery in Eosinophilic Chronic Rhinosinusitis

The Laryngoscope, EarlyView.
This study investigated perioperative changes in olfactory bulb volume (OBV) in patients with eosinophilic chronic rhinosinusitis using high‐resolution 3T MRI. Postoperative increases in OBV were associated with improvements in olfactory identification, suggesting a potential link between olfactory bulb structural plasticity and functional recovery ...
Keisuke Yamamoto, Masaki Abukawa, Tsuyoshi Okuni, Mitsuhiro Nakanishi, Yuki Sakurai, Naoya Yama, Noriko Ogasawara, Ryuta Kamekura, Kenichi Takano   +8 more
wiley   +1 more source

Association of blood inflammatory phenotypes and asthma burden in children with moderate-to-severe asthma

ERJ Open Research
Background Underlying immunological mechanisms in children with moderate-to-severe asthma are complex and unclear. We aimed to investigate the association between blood inflammatory parameters and asthma burden in children with moderate-to-severe asthma.
Amir Hossein Alizadeh Bahmani, Susanne J.H. Vijverberg, Simone Hashimoto, Christine Wolff, Catarina Almqvist, Lizan D. Bloemsma, Susanne Brandstetter, Paula Corcuera-Elosegui, Mario Gorenjak, Susanne Harner, Anna M. Hedman, Michael Kabesch, Leyre López-Fernández, Aletta D. Kraneveld, Anne H. Neerincx, Maria Pino-Yanes, Uroš Potočnik, Olaia Sardón-Prado, Barbara S. Dierdorp, Tamara Dekker, Nariman K.A. Metwally, Jan Willem Duitman, René Lutter, Paul Brinkman, Mahmoud I. Abdel-Aziz, Anke H. Maitland-van der Zee   +25 more
doaj   +1 more source

Evidence for the efficacy and safety of anti-interleukin-5 treatment in the management of refractory eosinophilic asthma

Therapeutic Advances in Respiratory Disease, 2015
Two recent phase III trials in patients with severe eosinophilic asthma have shown that anti-interleukin 5 (IL-5) therapy with mepolizumab reduces the frequency of asthma attacks, improves symptoms and allows patients to reduce oral glucocorticoid use ...
Bart Hilvering, Luzheng Xue, Ian D. Pavord   +2 more
doaj   +1 more source

Omalizumab as alternative to chronic use of oral corticosteroids in severe asthma

, 2019
Systemic/oral corticosteroids (OCS) have been used for decades in the management of acute asthma exacerbations and chronically in patients with uncontrolled severe asthma.
Bousquet, Jean, Brusselle, Guy, Buhl, Roland, Katsaounou, Paraskevi, Martinez, Rafael, Pfister, Pascal, Wahn, Ulrich   +6 more
core   +1 more source

Corticosteroid Exposure in Chronic Rhinosinusitis and Global Airway Disease: Adrenal and Bone Impact

The Laryngoscope, EarlyView.
ABSTRACT Objective To investigate cumulative corticosteroid (CC) burden in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), with or without coexisting asthma (global airway disease, GAD), referred for biologic treatment, and to assess the prevalence of CC‐related comorbidities, including secondary adrenal insufficiency, osteopenia and ...
Christiane Haase, Kjell Erik Julius Håkansson, Peter Schwarz, Kasper Aanæs, Jens Tidemandsen, Charlotte Suppli. Ulrik, Bente Appel Esbensen, Vibeke Backer   +7 more
wiley   +1 more source

Severe Asthma or Chronic Obstructive Pulmonary Disease with Eosinophilic Inflammation? From Uncertainty to Remission under Anti IL-5R Therapy

Medicina
Background and Objectives: Severe adult-onset eosinophilic asthma and COPD with eosinophilic inflammation are two entities with a similar clinical course and are sometimes difficult to differentiate in clinical practice, especially in patients with a ...
Bianca Oprescu, Oana Raduna, Stefan Mihaicuta, Stefan Frent   +3 more
doaj   +1 more source

In utero ultrafine particulate matter exposure causes offspring pulmonary immunosuppression. [PDF]

, 2019
Early life exposure to fine particulate matter (PM) in air is associated with infant respiratory disease and childhood asthma, but limited epidemiological data exist concerning the impacts of ultrafine particles (UFPs) on the etiology of childhood ...
Chang, Richard C-A, Golding, Michael C, Johnson, Natalie M, Langley, Rebecca, Lau, Carmen, Leal, Jeann, Li, Yixin, Molina, Mario J, Myatt, Louise G, Pulczinski, Jairus, Raju, Muppala, Rodrigues-Hoffmann, Aline, Rychlik, Kristal A, Secrest, Jeremiah R, Zamora, Misti L, Zhang, Renyi   +15 more
core  

Unique Features of Nasal Airway and Airflow Improvement Post‐Dupilumab: A Computational Cohort Study

The Laryngoscope, EarlyView.
The impact of dupilumab on nasal airway patency and airflow is not uniform. It is more pronounced in the middle and superior, but not inferior meatus. These unique regional changes significantly correlate with and potentially drive the improvement in patient symptoms.
Ahmad Odeh, Zhenxing Wu, Nidhi Jha, Aspen R. Schneller, James Mihalich, Zachary T. Root, Christopher Brooks, Casey Curtis, Monica Kraft, Kara Wada, Bradley A. Otto, Kathleen M. Kelly, Kai Zhao   +12 more
wiley   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source