Results 121 to 130 of about 1,917,601 (292)
Inflammatory Shift in Chronic Rhinosinusitis Amidst Guangzhou's Urbanization (2000–2018)
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background Chronic rhinosinusitis (CRS) exhibits temporal and geographic diversity in pathological endotypes with progressive eosinophilic infiltration, while the underlying causes remain unclear. Current pathological endotypes determination relies on mean cell count per high‐power field, requiring accuracy optimization.
Ning Kang +16 more
wiley +1 more source
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objective Budesonide is a corticosteroid with unique pharmacokinetic and pharmacodynamic properties that has been a frontline treatment for patients with allergic rhinitis (AR) and chronic rhinosinusitis (CRS) since the 1990s. As research on budesonide continues to produce new insights, our aim was to synthesize recent investigations and ...
David W. Kennedy +2 more
wiley +1 more source
Immune Clues to Sinus Blues: Linking Biomarkers to Radiologic Score of Rhinosinusitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background Chronic rhinosinusitis (CRS) is a prolonged inflammatory condition of the nasal and paranasal sinuses that significantly affects quality of life. This study examines the relationship between CRS severity (based on Lund‐Mackay [LM] scores), osteitis, and systemic inflammatory markers, including neutrophil‐to‐lymphocyte ratio (NLR ...
Lubna Khreesha +10 more
wiley +1 more source
Frontiers in PharmacologyArachidonic acid (AA) metabolites play key roles in the pathophysiology of asthma. Along with cyclooxygenase and CYP P450, lipoxygenases (LO) produce these metabolites. 15-hydroxyeicosatetraenoic acid (15-HETE), a product of 15-LO, has been implicated in
Andrew Engel, Zhenying Nie, Sanjiv Kaul
doaj +1 more source
Personalized Surgery for Allergic Fungal Rhinosinusitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background Allergic fungal rhinosinusitis (AFRS) frequently presents as unilateral or asymmetric disease. In cases with minimal disease on one side, the question remains as to the necessary extent of surgery. Objective To determine the relationship between symmetry and clinical characteristics in AFRS patients, with a focus on implications for
Erin E. Briggs +7 more
wiley +1 more source
The Global Airways Unit: A Multidisciplinary Strategy for Early Diagnosis and Comorbidity Detection
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background Chronic respiratory diseases impose a large global burden of morbidity, mortality, and cost. The concept of a global airway has become increasingly supported by epidemiologic, mechanistic, and clinical evidence. However, clinical care often remains fragmented between ear, nose, and throat (ENT), allergy, and pulmonology.
Diego M. Conti +16 more
wiley +1 more source
Eosinophilic Sialodochitis Identified in Duct Remnant After Submandibular Gland Resection
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Eosinophilic sialodochitis (ES) is an increasingly recognized cause of recurrent sialadenitis but likely remains underdiagnosed as it is commonly considered to be nonspecific chronic sialadenitis. ES is likely increasing in prevalence in association with the growing number of allergic diseases and should be considered in patients presenting ...
Edward Tannenbaum +3 more
wiley +1 more source
TNF Superfamily and ILC2 Activation in Asthma
BiomoleculesEosinophilic asthma is the most prevalent and well-defined phenotype of asthma. Despite a majority of patients responding to corticosteroid therapy and T2 biologics, there remains a subset that have recurrent asthma exacerbations, highlighting a need for
Takahiro Matsuyama +4 more
doaj +1 more source
Twice-Yearly Depemokimab in Severe Asthma with an Eosinophilic Phenotype
New England Journal of MedicineDepemokimab is an ultra-long-acting biologic therapy with enhanced binding affinity for interleukin-5 that may enable effective 6-month dosing intervals.In these phase 3A, randomized, placebo-controlled replicate trials, we evaluated the efficacy and safety of depemokimab in patients with severe asthma and an eosinophilic phenotype characterized by a ...
David J Jackson +205 more
openaire +3 more sources
Turbinoplasty Versus Medical Treatment for Allergic Rhinitis: A Systematic Review and Meta‐Analysis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objective Allergic rhinitis is a common chronic condition affecting up to 30% of adults worldwide, with nasal obstruction being the most bothersome symptom. Inferior turbinate hypertrophy is a major contributor to nasal obstruction in allergic rhinitis, and surgical reduction techniques have been developed for cases refractory to medical ...
Noof Albannai +12 more
wiley +1 more source