Results 61 to 70 of about 327,068 (394)

A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED [PDF]

, 2016
RATIONALE AND OBJECTIVES: Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms. We used transcriptomic profiling of airway tissues to help define asthma phenotypes. METHODS: The transcriptome from bronchial biopsies
Adcock, IM, Auffray, C, Baribaud, F, Chanez, P, Chung, KF, Corfield, J, Dahlen, B, Dahlen, SE, De Meulder, B, Djukanovic, R, Fleming, L, Fowler, S, Guo, Y, Hoda, U, Howarth, P, Krug, N, Kuo, CS, Lefaudeux, D, Loza, M, Pandis, I, Pavlidis, S, Rossios, C, Rowe, A, Sandström, T, Shaw, D, Sousa, A, Sterk, PJ, U-BIOPRED Project Team, Wilson, SJ   +28 more
core   +4 more sources

Eosinophils and childhood asthma [PDF]

Clinical and Experimental Pediatrics, 2021
Eosinophils are a type of granulocyte with eosinophilic granules in the cytoplasm that play an important role in allergic and parasitic diseases. Eosinophils are important in the pathogenesis of asthma, and many studies have examined the relationship ...
Bong Seok Choi
doaj   +1 more source

Benralizumab improves symptoms of patients with severe, eosinophilic asthma with a diagnosis of nasal polyposis

Allergy. European Journal of Allergy and Clinical Immunology, 2021
Clinically meaningful improvement in the Sino‐Nasal Outcome Test‐22 (SNOT‐22) was observed in patients with severe, eosinophilic asthma, and nasal polyposis (NP) treated with benralizumab in the ANDHI trial.
G. Canonica, T. Harrison, P. Chanez, F. Menzella, R. Louis, B. Cosío, N. Lugogo, A. Mohan, A. Burden, E. Garcia Gil   +9 more
semanticscholar   +1 more source

Sputum Hyaluronan and Versican in Severe Eosinophilic Asthma [PDF]

International Archives of Allergy and Immunology, 2012
<b><i>Background:</i></b> We examined levels of hyaluronan, a matrix glycosaminoglycan and versican, a matrix proteoglycan, in the sputum of asthmatics treated with mepolizumab (anti-IL-5 monoclonal antibody) versus placebo to evaluate the utility of these measurements as possible biomarkers of asthma control and airway ...
Thomas N. Wight, Parameswaran Nair, Katherine Radford, Leonard C. Altman, Andrew G. Ayars, Sue Potter-Perigo   +5 more
openaire   +2 more sources

May mepolizumab used in asthma correct subfertility?

Annals of Medicine, 2021
İntroduction Asthma is one of the most common chronic airway disease among reproductive period of women. Chronic inflammation in asthma, eosinophilia, high steroid treatment and uncontrolled asthma may cause infertility by affecting the reproductive ...
Guzin Ozden, Pelin Pınar Deniz
doaj   +1 more source

IoT-Based Remote Health Monitoring System Employing Smart Sensors for Asthma Patients during COVID-19 Pandemic [PDF]

, 2023
COVID19 and asthma are respiratory diseases that can be life threatening in uncontrolled circumstances and require continuous monitoring. A poverty stricken South Asian country like Bangladesh has been bearing the brunt of the COVID19 pandemic since its beginning.
arxiv   +1 more source

Benralizumab in Patients With Severe Eosinophilic Asthma With and Without Chronic Rhinosinusitis With Nasal Polyps: An ANANKE Study post-hoc Analysis

Frontiers in Allergy, 2022
Background Severe eosinophilic asthma (SEA) in the presence of chronic rhinosinusitis with nasal polyps (CRSwNP) indicates the presence of a more extensive eosinophilic inflammation.
M. D’Amato, F. Menzella, E. Altieri, E. Bargagli, P. Bracciale, L. Brussino, M. Caiaffa, G. Canonica, C. Caruso, S. Centanni, F. De Michele, F. Di Marco, E. Pastorello, G. Pelaia, P. Rogliani, M. Romagnoli, Pietro Schino, G. Senna, A. Vultaggio, A. Ori, L. Simoni, S. Boarino, G. Vitiello, M. Aliani, S. D. Del Giacco   +24 more
semanticscholar   +1 more source

Asthma Control in Patients with Severe Eosinophilic Asthma Treated with Reslizumab: Spanish Real-Life Data

Journal of Asthma and Allergy, 2022
Background Reslizumab is an anti-interleukin 5 monoclonal antibody that has demonstrated to reduce the risk of severe exacerbations and to improve symptoms, lung function, and quality of life in randomized controlled trials that included patients with ...
L. A. Pérez de Llano, B. Cosío, I. Lobato Astiárraga, G. Soto Campos, M. A. Tejedor Alonso, N. Marina Malanda, A. Padilla Galo, I. Urrutia Landa, F. J. Michel de la Rosa, I. García-Moguel   +9 more
semanticscholar   +1 more source

Eosinophil‐derived neurotoxin and clinical outcomes with mepolizumab in severe eosinophilic asthma [PDF]

Allergy, 2020
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Peter H. Howarth, Santiago Quirce, Steve Yancey, Namhee Kwon, Frank C. Albers, Stewart Bates, Alberto Papi, Alberto Papi, Stephen Mallett, Elliot Israel   +9 more
openaire   +5 more sources

Distinct functions of eosinophils in severe asthma with type 2 phenotype: clinical implications [PDF]

The Korean Journal of Internal Medicine, 2020
Asthma is commonly recognized as a heterogeneous condition with a complex pathophysiology. With advances in the development of multiple medications for patients with asthma, most asthma symptoms are well managed.
Youngwoo Choi, Soyoon Sim, Hae-Sim Park
doaj   +1 more source