Results 71 to 80 of about 1,917,601 (292)

Coexistence of immunophenotypically normal and aberrant mast cells in patients with clonal mast cell diseases associates with more indolent subtypes and less severe disease characteristics

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Aberrant antigen expression on mast cells (MCs) is one of the most accurate diagnostic markers for clonal MC diseases (CMCD). Although the coexistence of normal and pathologic MCs is frequently seen, the disease characteristics associated with it have been minimally investigated.
Abdulrazzaq Alheraky, Kees Meijer, Marije Nijk, Saskia K. Klein, Hanneke N. G. Oude Elberink, Ido P. Kema, André B. Mulder   +6 more
wiley   +1 more source

Tracheal wash culture is not associated with bronchial infection, remodelling or inflammation in horses with asthma

Equine Veterinary Journal, EarlyView.
Abstract Background Antimicrobials are commonly prescribed for the treatment of equine asthma, despite limited evidence supporting their use. Tracheal wash (TW) bacterial culture results are known to influence antimicrobial prescription decisions. Objectives To determine whether a positive TW bacterial culture in horses with asthma is associated with ...
Laurence Leduc, Guillaume St‐Jean, Jean‐Pierre Lavoie   +2 more
wiley   +1 more source

Regulatory T cell monitoring in severe eosinophilic asthma patients treated with mepolizumab

, 2021
Severe eosinophilic asthma (SEA) has been associated with T-helper type 2 (Th2) inflammatory response. A good understanding of T cell functions in asthma is important for therapy, especially in the choice of biological treatments for severe cases ...
Francesco Dotta, Bargagli, Elena, Pini, Laura, Miriana d’Alessandro, Biagini, Marco, Sestini, Piersante, Perruzza, Marco, Dotta, Francesco, Laura Bergantini, Cameli, Paolo, Bono, Clara, Marco Perruzza, Elena Bargagli, Bigliazzi, Caterina, Bergantini, Laura, Paolo Cameli, Piersante Sestini, Marco Biagini, d'Alessandro, Miriana, Caterina Bigliazzi, Clara Bono, Laura Pini   +21 more
core   +1 more source

System‐Local Axes and Metabolic Reprogramming From Health to Response in House Dust Mite‐Specific Subcutaneous Immunotherapy for Allergic Rhinitis

iMetaMed, EarlyView.
This study delineated nasal‐plasma metabolic reprogramming in house dust mite‐allergic rhinitis (HDM‐AR) and subcutaneous immunotherapy (SCIT) response, showing compartment‐specific signatures dominated by nasal lipid‐redox and plasma nucleotide‐NAD+ axes and across the HC–HDM‐AR–SCIT response continuum, dual‑compartment metabolites exhibited ...
Bixing Fang, Fei Pan, Yachun Li, Yimeng Wang, Ze Wang, Zhiheng Huang, Ming Chen, Yun Li, Mengli Huang, Cheng Guo, Chubo Xie, Lina Dong, Yadong Gao, Zhuohang Yu   +13 more
wiley   +1 more source

Chronic conditions associated with paediatric onset inflammatory bowel diseases: A population‐based study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objective Several conditions are associated with inflammatory bowel disease (IBD), including immune‐mediated inflammatory diseases (IMIDs), extraintestinal manifestations (EIMs), and psychiatric disorders. This study aimed to describe at population‐level the comorbidities and their relative burden in paediatric‐onset IBD (pIBD).
Nicolas Richard, Ariane Leroyer, Hélène Sarter, Claire Dupont, Dominique Turck, Valérie Bertrand, Pauline Wils, Corinne Gower‐Rousseau, Guillaume Savoye, Nathalie Guillon, Delphine Ley, Mathurin Fumery, EPIMAD Study Group, R. Al Hameedi, M. Al Khatib, S. Al Turk, E. Agoute, J.M. Andre, M. Antonietti, A. Aouakli, A. Armand, L. Armengol‐Debeir, I. Aroichane, F. Assi, J.P. Aubet, E. Auxenfants, A. Avram, F. Ayafi‐Ramelot, K. Azzouzi, D. Bankovski, B. Barbry, N. Bardoux, P. Baron, A. Baudet, P. Bayart, B. Bazin, A. Bebahani, J.P. Becqwort, S. Bellati, V. Benet, H. Benali, C. Benard, C. Benguigui, E. Ben Soussan, A. Bental, I. Berkelmans, J. Bernet, K. Bernou, C. Bernou‐Dron, P. Bertot, N. Bertiaux‐Vandaële, V. Bertrand, E. Billoud, N. Biron, B. Bismuth, M. Bleuet, F. Blondel, V. Blondin, M. Bobula, P. Bohon, V. Bondjemah, E. Boniface, D. Bonkovski, P. Bonnière, E. Bonvarlet, P. Bonvarlet, A. Boruchowicz, R. Bostvironnois, M. Boualit, A. Bouazza, B. Bouche, C. Boudaillez, C. Bourgeaux, M. Bourgeois, A. Bourguet, A. Bourienne, H. Boutaleb, A. Bouthors, J. Branche, G. Bray, F. Brazier, P. Breban, M. Bridenne, H. Brihier, L. Bril, V. Brung‐Lefebvre, P. Bulois, P. Burgiere, J. Butel, J.Y. Canva, V. Canva‐Delcambre, J.P. Capron, F. Cardot, S. Carette, P. Carpentier, E. Cartier, J.F. Cassar, M. Cassagnou, J.F. Castex, P. Catala, S. Cattan, S. Catteau, B. Caujolle, G. Cayron, C. Chandelier, M. Chantre, J. Charles, T. Charneau, M. Chavance‐Thelu, A. Cheny, D. Chirita, A. Choteau, J.F. Claerbout, P.Y. Clergue, H. Coevoet, G. Cohen, R. Collet, M. Colin, J.F. Colombel, S. Coopman, L. Cordiez, J. Corvisart, A. Cortot, F. Couttenier, J.F. Crinquette, V. Crombe, I. Dadamessi, H. Daoudi, V. Dapvril, T. Davion, S. Dautreme, J. Debas, S. Decoster, N. Degrave, F. Dehont, C. Delatre, R. Delcenserie, D. Delesalle, O. Delette, T. Delgrange, L. Delhoustal, J.S. Delmotte, S. Demmane, G. Deregnaucourt, P. Descombes, J.P. Desechalliers, P. Desmet, P. Desreumaux, G. Desseaux, P. Desurmont, A. Devienne, E. Devouge, M. Devred, A. Devroux, A. Dewailly, S. Dharancy, A. Di Fiore, D. Djedir, R. Djedir, W. Doleh, Ml. Dreher‐Duwat, R. Dubois, C. Duburque, P. Ducatillon, J. Duclay, B. Ducrocq, F. Ducrot, P. Ducrotte, A. Dufilho, C. Duhamel, D. Dujardin, C. Dumant‐Forest, J.L. Dupas, F. Dupont, Y. Duranton, A. Duriez, N. Duveau, K. El Achkar, M. El Farisi, C. Elie, M.C. Elie‐Legrand, A. Elkhaki, M. Eoche, E. Essmaeel, D. Evrard, J.P. Evrard, A. Fatome, B. Filoche, L. Finet, M. Flahaut, C. Flamme, D. Foissey, P. Fournier, Mc. Foutrein‐ Comes, P. Foutrein, D. Fremond, T. Frere, M. Fumery, P. Gallais, C. Gamblin, S. Ganga, R. Gerard, G. Geslin, Y. Gheyssens, N. Ghossini, S. Ghrib, T Gilbert, B. Gillet, D. Godart, P. Godard, J.M. Godchaux, R. Godchaux, G. Goegebeur, O. Goria, F. Gottrand, P. Gower, B. Grandmaison, M. Groux, C. Guedon, L. Guerbeau, M. Gueroult‐Dero, J.F. Guillard, L. Guillem, F. Guillemot, D. Guimberd, B. Haddouche, S. Hakim, D. Hanon, V. Hautefeuille, P. Heckestweiller, G. Hecquet, J.P. Hedde, H. Hellal, P.E. Henneresse, B. Heyman, M. Heraud, S. Herve, P. Hochain, L. Houssin‐Bailly, P. Houcke, B. Huguenin, S. Iobagiu, S. Istanboli, A. Ivanovic, I. Iwanicki‐Caron, E. Janicki, M. Jarry, J. Jeu, Jp. Joly, C. Jonas, A. Jouvenet, F. Katherin, A. Kerleveo, A. Khachfe, A. Kiriakos, J. Kiriakos, O. Klein, M. Kohut, R. Kornhauser, D. Koutsomanis, Je. Laberenne, E. Lacotte, G. Laffineur, M. Lagarde, A. Lalanne, A. Lalieu, P. Lannoy, J. Lapchin, M. Laprand, D. Laude, R. Leblanc, P. Lecieux, S. Lecleire, N. Leclerc, C. Le Couteulx, J. Ledent, J. Lefebvre, P. Lefiliatre, C. Le Goffic, C. Legrand, A. Le Grix, P. Lelong, B. Leluyer, C. Lemaitre, C. Lenaerts, G. Lepeut, L. Lepileur, A. Leplat, E. Lepoutre‐Dujardin, H. Leroi, M.Y. Leroy, P. Le Roy, B. Lesage, Jp. Lesage, X. Lesage, J. Lesage, I. Lescanne‐Darchis, J. Lescut, D. Lescut, B. Leurent, P. Levy, M. Lhermie, L. Libier, A. Lion, B. Lisambert, I. Loge, F. Loire, J. Loreau, S. Louf, A. Louvet, L. Lubret, M. Luciani, D. Lucidarme, J. Lugand, O. Macaigne, D. Maetz, D. Maillard, H. Mancheron, O. Manolache, Ab. Marks‐Brunel, C. Marre, R. Marti, F. Martin, G. Martin, E. Marzloff, P. Mathurin, J. Mauillon, V. Maunoury, J.L. Maupas, Ma. Medam Djomo, C. Mechior, Z. Melki, B. Mesnard, P. Metayer, L. Methari, B. Meurisse, F. Meurisse, L. Michaud, X. Mirmaran, P. Modaine, A. Monthe, L. Morel, P.E. Mortier, E. Moulin, O. Mouterde, N. Mozziconaci, J. Mudry, M. Nachury, Md. Ngo, E. N'Guyen Khac, B. Notteghem, V. Ollevier, A. Ostyn, A. Ouraghi, B. Oussadou, D. Ouvry, B. Paillot, C. Painchart, N. Panien‐Claudot, C. Paoletti, A. Papazian, B. Parent, B. Pariente, Jc. Paris, P. Patrier, T. Paupard, B. Pauwels, M. Pauwels, E. Penninck, R. Petit, M. Piat, S. Piotte, C. Plane, B. Plouvier, E. Pollet, P. Pommelet, D. Pop, C. Pordes, G. Pouchain, P. Prades, A. Prevost, Jc. Prevost, G. Quartier, B. Quesnel, A.M. Queuniet, Jf. Quinton, A. Rabache, P. Rabelle, G. Raclot, S. Ratajczyk, D. Rault, V. Razemon, N. Reix, T. Renaut‐Vantroys, M. Revillion, G. Riachi, C. Richez, P. Robinson, J. Rodriguez, J. Roger, J.M. Roux, A. Rudelli, A. Saber, G. Savoye, P. Schlossberg, D. Sefrioui, M. Segrestin, D. Seguy, C. Seminur, M. Serin, A. Seryer, F. Sevenet, N. Shekh, J. Silvie, V. Simon, C. Spyckerelle, N. Talbodec, N. Tavernier, H. Tchandeu, A. Techy, J.L. Thelu, A. Thevenin, H. Thiebault, J. Thomas, J.M. Thorel, C. Thuillier, G. Tielman, M. Tode, J. Toisin, J. Tonnel, Jy. Touchais, P. Toumelin, Y. Touze, J.L. Tranvouez, C. Triplet, N. Triki, D. Turck, S. Uhlen, E. Vaillant, C. Valmage, D. Vanco, N. Vandaele‐Bertiaux, H. Vandamme, E. Vanderbecq, E. Vander Eecken, P. Vandermolen, P. Vandevenne, L. Vandeville, A. Vandewalle, C. Vandewalle, P. Vaneslander, J.P. Vanhoove, A. Vanrenterghem, C. Vanveuren, P. Varlet, I. Vasies, G. Verbiese, J. Verlynde, G. Vernier‐Massouille, P. Vermelle, C. Verne, P. Vezilier‐Cocq, B. Vigneron, M. Vincendet, J. Viot, Y.M. Voiment, A. Wacrenier, L. Waeghemaecker, J.Y. Wallez, M. Wantiez, F. Wartel, J. Weber, J.L. Willocquet, N. Wizla, E. Wolschies, O. Zaharia, S. Zaoui, A. Zalar, B. Zaouri, A. Zellweger, C. Ziade   +480 more
wiley   +1 more source

Mepolizumab, quality of life, and severe eosinophilic asthma [PDF]

The Lancet Respiratory Medicine, 2017
It is now ten years since the publication of the first clinical trial, eight years since the first key proof of concept studies in a population selected on the basis of inflammatory pattern and two years since approval of Mepolizumab as a treatment for severe eosinophilic asthma.
openaire   +3 more sources

Type II achalasia unmasked by EndoFLIP and high‐resolution manometry in a child with eosinophilic esophagitis

JPGN Reports, EarlyView.
ABSTRACT Eosinophilic esophagitis (EoE) is a chronic immune‐mediated disease characterized by esophageal dysfunction and eosinophilic inflammation. Persistent dysphagia despite histologic remission should prompt evaluation for alternative etiologies. A 10‐year‐old male with asthma and eczema presented with progressive solid food dysphagia, daily non ...
Rasha Abi Radi Abou Jaoudeh, Jose M. Garza, Chathruckan Rajendra   +2 more
wiley   +1 more source

Achieving clinical and histologic remission with tezepelumab in an adolescent with refractory eosinophilic gastrointestinal disease: A case report

JPGN Reports, EarlyView.
Abstract Tezepelumab is a human monoclonal antibody that binds to human thymic stromal lymphopoietin (TSLP), an epithelial cytokine that plays a role in Type 2 signaling. We describe a 17‐year‐old with a history of eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis who demonstrated response to tezepelumab with both clinical and histologic ...
Destiny Newsome, Colby Sharlin, Cindy Salm Bauer, Shauna Schroeder   +3 more
wiley   +1 more source

Aerodigestive evaluation in patients with eosinophilic asthma

Respiratory Medicine Case Reports
We present two pediatric patients with severe uncontrolled asthma who underwent aerodigestive evaluation revealing eosinophilic asthma and eosinophilic esophageal inflammation.
Chloe Citron, Jessica Erkman, Mikhail Kazachkov, Anna Nowak-Wegrzyn, Deniz Kesebir   +4 more
doaj   +1 more source

Determinação do componente inflamatório das doenças das vias aéreas através do escarro induzido: utilização na prática clínica [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-graduação em Ciências MédicasIntrodução: Além de um importante instrumento de pesquisa, a celularidade do escarro induzido (EI) vem sendo ...
Moritz, Pablo
core