Results 81 to 90 of about 1,750,371 (298)

Efficacy and safety of empagliflozin for treating neutropenia and neutrophil dysfunction in paediatric patients with glycogen storage disease type Ib: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Glycogen storage disease type Ib (GSD‐Ib) is a rare genetic disorder causing neutropenia and neutrophil dysfunction in children. G‐CSF has been the primary treatment, but emerging data support the potential of empagliflozin, an SGLT2 inhibitor, as a promising investigational option.
Elizabeth Iwasyk, Ryan Jin, Fabio Tuzzolino, Giusy Ranucci, Donatella Madonia, Alessio Provenzani   +5 more
wiley   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin, Marie A. Onyamboko, Caterina Fanello, Nicholas J. White, Nicholas P. J. Day, Richard M. Hoglund, Joel Tarning   +6 more
wiley   +1 more source

Moxifloxacin: A Unique Cause of Severe Hypoglycemia

, 2016
As a class, quinolone antibiotics have been rarely associated with hypoglycemia in non-diabetic patients and rare reversible episodes of hypoglycemia documented in the literature typically occur within the duration of action of the medication.
Raschke, Jeremy, Khashaei, Sepehr, Ball, Emily   +2 more
core  

Comparative risk of severe hypoglycemia among concomitant users of thiazolidinedione antidiabetic agents and antihyperlipidemics

, 2016
We conducted high-dimensional propensity score-adjusted cohort studies to examine whether thiazolidinedione use with a statin or fibrate was associated with an increased risk of severe hypoglycemia.
Brensinger, Colleen M., Bilker, Warren B., Gagne, Joshua J., Cardillo, Serena, Flockhart, David A., Hennessy, Sean, Leonard, Charles E., Han, Xu, Flory, James H.   +8 more
core   +1 more source

Current practice and guideline adherence in renal dose adjustment for patients with chronic kidney disease: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed, Ahmed Tehemar, Mohamed Gasimelseed, Ahmed Gharaibeh, Muhammad Abdul Hadi, Kazeem Yusuff, Amani Zidan, Ahmed Awaisu   +7 more
wiley   +1 more source

The Effect of Recurrent Severe Hypoglycemia on Cognitive Performance in Children With Type 1 Diabetes

, 2011
The purpose of this study was to investigate the existence and extent of cognitive impairment in type 1 diabetic children with episodes of recurrent severe hypoglycemia, using meta-analysis to synthesize data across studies.
Verrotti, Alberto, Tocco, Anna Maria, Peter A. Mattei, BALLONE, ENZO, Annalisa Blasetti, Concetta Di Giulio, Blasetti, Annalisa, Chiuri, Rosa Maria, Mattei, Peter A., Alberto Verrotti, Chiarelli, Francesco, Enzo Ballone, Francesco Chiarelli, Giulio, Concetta Di, Rosa Maria Chiuri, Anna Maria Tocco   +15 more
core   +1 more source

Multidisciplinary strategies to treat severe hypoglycemia in hospitalized patients with diabetes mellitus reduce inpatient mortality rate: Experience from an academic community hospital.

PLoS ONE, 2019
ObjectiveSevere hypoglycemia (blood glucose < 50 mg/dl) in hospitalized patients with diabetes mellitus is associated with poor outcomes such as increased mortality and readmission rates.
Deepak Kana Kadayakkara, Priyadarshini Balasubramanian, Katherine Araque, Karri Davis, Fahad Javed, Pontea Niaki, Sachin Majumdar, Gregory Buller   +7 more
doaj   +1 more source

Safety outcomes of antidiabetic medications: A comprehensive review of the EU summaries of product characteristics and international clinical practice guidelines

British Journal of Clinical Pharmacology, EarlyView.
Aims Information on the safety profile of antidiabetic medications is essential for informed treatment decisions in type 2 diabetes mellitus. Although this information is available in regulatory documents of individual drugs, a comprehensive overview across all approved antidiabetics is lacking.
David Liang, Daniala L. Weir, Safana Thevasahayam, Vera H. M. Deneer, Arno Siebes, Helga Gardarsdottir   +5 more
wiley   +1 more source

Observational study of the relationship between the use of real-time continuous glucose monitoring and glycemic control in patients with diabetes in Japan: the REALJ study

Endocrine Journal
Although randomized controlled trials have demonstrated the efficacy of real-time continuous glucose monitoring (rtCGM), evidence from routine clinical practice remains limited, particularly in Asian populations.
Masao Toyoda, Naoki Sakane, Akiko Suganuma, Masahito Ogura, Junnosuke Miura, Daisuke Tsuriya, Akinori Hayashi, Hideaki Sawaki, Shota Suzuki, Tatsuhiko Urakami, Yushi Hirota, Arata Itoh, Shu Meguro, Kenji Kamiuchi, Tomokazu Matsuda, Hitomi Nakayama, Yoshihiko Yuyama, Tomoyuki Kawamura, Atsuhito Tone, Ken Kato, Akira Kuroe, Akio Kuroda, Munehide Matsuhisa, Akira Shimada, Takashi Murata, The REALJ Study Group   +25 more
doaj   +1 more source