Results 101 to 110 of about 110,606 (268)

Investigation of host candidate malaria-associated risk/protective SNPs in a Brazilian Amazonian population. [PDF]

, 2012
The Brazilian Amazon is a hypo-endemic malaria region with nearly 300,000 cases each year. A variety of genetic polymorphisms, particularly in erythrocyte receptors and immune response related genes, have been described to be associated with ...
Rockett, Kirk A., Fernandes, O, da Silva Santos, S, Campino Susana, Martha Cecília Suarez-Mutis, Martha Cecília Suarez-Mutis (164115), Simone da Silva Santos, Santos, Simone da Silva, Fernandes, Octavio, Dominic P. Kwiatkowski (106264), Susana Campino, Kirk A Rockett, Kirk A. Rockett (138127), Kwiatkowski, DP, Rockett, Kirk A, Octavio Fernandes (16216), Kwiatkowski, Dominic, Dominic P Kwiatkowski, Kwiatkowski Dominic P., Taane G Clark, Suarez-Mutis, MC, Campino, Susana, da Silva Santos Simone, Taane G. Clark (106263), Susana Campino (56411), Clark, Taane G., Rockett, KA, Rockett Kirk A., Suarez-Mutis, Martha Cecília, Clark Taane G., Octavio Fernandes, Simone da Silva Santos (164105), Kwiatkowski, Dominic P., Campino, S, Suarez-Mutis Martha Cecília, da Silva Santos, Simone, Clark, Taane G, Clark, TG, Kwiatkowski, Dominic P, Fernandes Octavio   +39 more
core   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

The Economic Costs of Malaria in Children in three Sub-Saharan Countries: Ghana, Tanzania and Kenya. [PDF]

, 2013
Malaria causes significant mortality and morbidity in sub-Saharan Africa (SSA), especially among children less than five years of age (U5 children).
Sicuri, E, Constenla, Dagna, Dagna Constenla, Elisa Sicuri, Sicuri, Elisa, Vieta, Ana, Constenla, D, Christophe Sauboin, Lindner, Leandro, Vieta, A, Ana Vieta, Lindner, L, Sauboin, C, Sauboin, Christophe, Leandro Lindner   +14 more
core   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

The Hidden Costs of Coffee Production in the Eastern African Value Chains

Sustainable Development, EarlyView.
ABSTRACT There is increasing recognition that significant hidden costs associated with agrifood systems are not reflected in market prices. Coffee is among the three most traded agricultural commodities in the world and supports the livelihoods of more than 30 million smallholder households.
Annet Adong, Lukas Kornher, Bezawit Beyene Chichaibelu, Aslihan Arslan   +3 more
wiley   +1 more source

Disease progression in Plasmodium knowlesi malaria is linked to variation in invasion gene family members. [PDF]

, 2014
Emerging pathogens undermine initiatives to control the global health impact of infectious diseases. Zoonotic malaria is no exception. Plasmodium knowlesi, a malaria parasite of Southeast Asian macaques, has entered the human population. P.
Paul C. Divis (615586), Lynch, Sean, Ahmed Atique M., Wong, Ing Tien, Scott B. Millar, Scott B, Millar, Scott B Millar, Ahmed, Atique M., Paul C Divis, Chan Woon Lu (615590), Janet Cox-Singh (218129), Divis Paul C., Singh Balbir, Siner Angela, Balbir, Singh, Singh, Balbir, Miguel M. Pinheiro, Janet Cox-Singh, Ahmed, AM, Singh, B, Balbir Singh, Wong Ing Tien, Janet, Cox-Singh, Singh-Khaira, Sarina K., Millar, SB, Ramlah Zainudin (615588), Matthias, Willmann, Lynch, S, Ing Tien Wong (615589), Wong, IT, Scott B. Millar (615592), Ing Tien Wong, Sanjeev Krishna (4917), Siner, A, Paul C, Divis, Miguel M. Pinheiro (615585), Pinheiro, MM, Matthias Willmann (615594), Sanjeev, Krishna, Lu, CW, Atique M. Ahmed (615584), Millar Scott B., Atique M Ahmed, Lynch Sean, Atique M, Ahmed, Sanjeev Krishna, Sean Lynch (615593), Monsanto Pinheiro, Miguel, Sarina K Singh-Khaira, Pinheiro Miguel M., Lu Chan Woon, Cox-Singh, J, Miguel M, Pinheiro, Zainudin, Ramlah, Divis, Paul C., Siner, Angela, Cox-Singh, Janet, Miguel M Pinheiro, Balbir Singh (218132), Willmann, M, Zainudin Ramlah, Willmann, Matthias, Tien, Wong, Sean Lynch, Paul C. Divis, Millar, Scott B., Cox-Singh Janet, Atique M. Ahmed, Sarina K, Singh-Khaira, Chan Woon Lu, Krishna Sanjeev, Zainudin, R, Lu, Chan Woon, Sarina K. Singh-Khaira, Angela Siner, Cox Singh, Janet, Singh-Khaira Sarina K., Singh-Khaira, SK, Willmann Matthias, Ramlah, Zainudin, Matthias Willmann, Chan, Woon Lu, Angela, Siner, Krishna, S, Sean, Lynch, Krishna, Sanjeev, Angela Siner (615587), Sarina K. Singh-Khaira (615591), Ramlah Zainudin, Pinheiro, Miguel M., Divis, PC   +90 more
core   +1 more source

Diabetes and metabolic syndrome in adults with malaria and associations with severe disease: results from two tertiary hospitals in Cameroon

BMC Infectious Diseases
Background The prevalence of lifestyle-associated diseases is increasing in sub-Saharan Africa. This study investigated the prevalence of metabolic co-morbidities in adults with malaria and whether type 2 diabetes, obesity, and metabolic syndrome (Met-S)
George Awungafac, Sylvain Raoul Simeni Njonnou, Michel Noubom, Leila Ingrid Angeline Avezo’o Libon, Caroline Ngunyi Gesu, Anna Färnert, Siméon Pierre Choukem, Katja Wyss   +7 more
doaj   +1 more source

Clinical and epidemiological characterization of severe Plasmodium vivax malaria in Gujarat, India

Virulence, 2020
The mounting evidence supporting the capacity of Plasmodium vivax to cause severe disease has prompted the need for a better characterization of the resulting clinical complications. India is making progress with reducing malaria, but epidemics of severe
Anupkumar R. Anvikar, Anna Maria van Eijk, Asha Shah, Kamlesh J. Upadhyay, Steven A. Sullivan, Ankita J. Patel, Jaykumar M. Joshi, Suchi Tyagi, Ranvir Singh, Jane M. Carlton, Himanshu Gupta, Samuel C. Wassmer   +11 more
doaj   +1 more source

Illegal Gold Mining in the Brazilian Amazon: Environmental Degradation in Yanomami Indigenous Lands, and Regulatory Failures

Sustainable Development, EarlyView.
ABSTRACT Illegal gold mining has emerged as a major sustainability threat in the Amazon, eroding Indigenous rights, forest integrity, and climate mitigation efforts. This study examines how international market incentives relate to the expansion of illegal mining and associated deforestation within the Yanomami Indigenous Territory (YIT) from 2008 to ...
Shirléia Lago Santos, Ana Claudia de Araujo Moxotó, Jurandir Moura Dutra   +2 more
wiley   +1 more source

Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies. [PDF]

, 2008
BACKGROUND: Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain.
Hastings, Ian M, Day, Nicholas PJ, White, Nicholas J., Dondorp, AM, Hastings, Ian M., Dondorp, Arjen M, Dondorp, Adrianus, Hastings, Ian, Day, Nicholas P. J., Pongtavornpinyo, W, Hastings, IM, Pongtavornpinyo, Wirichada, White, Nicholas J, Day, Nicholas, Day, Nicholas P.J., Yeung, Shunmay, Day, NP, White, NJ, White, Nicholas, Dondorp, Arjen M., Yeung, S   +20 more
core   +1 more source