Results 91 to 100 of about 1,804,243 (315)

An epidemiological analysis of severe imported malaria infections in Sri Lanka, after malaria elimination

Malaria Journal
Background Imported malaria continues to be reported in Sri Lanka after it was eliminated in 2012, and a few progress to life-threatening severe malaria.
Shilanthi Seneviratne, Deepika Fernando, Rajitha Wickremasinghe, Sujai Senarathne, Pubudu Chulasiri, Nethmini Thenuwara, Champa Aluthweera, Iromi Mohotti, Shamila Jayakuru, Thilan Fernando, Anula Wijesundara, Rohini Fernandopulle, Kamini Mendis   +12 more
doaj   +1 more source

Clinical Features and Mortality Associated with Severe Malaria in Adults in Southern Mauritania

Tropical Medicine and Infectious Disease, 2020
Severe malaria in adults is not well-studied in Sahelian Africa. Clinical features and mortality associated with severe Plasmodium falciparum malaria in adult patients hospitalized in Kiffa, southern Mauritania, were analysed.
Boushab Mohamed Boushab, Mohamed Salem Ould Ahmedou Salem, Ali Ould Mohamed Salem Boukhary, Philippe Parola, Leonardo Basco   +4 more
doaj   +1 more source

Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. [PDF]

, 2009
BACKGROUND: Limited tools exist to identify which individuals infected with Plasmodium falciparum are at risk of developing serious complications such as cerebral malaria (CM). The objective of this study was to assess serum biomarkers that differentiate
Hawkes, Michael, Nimerta Rajwans, Michael Hawkes, Kevin C Kain, Lafferty, Erin I., John, Chandy C, Sornchai Looareesuwan, Srivicha Krudsood, Tangpukdee, Noppadon, Lafferty, Erin I, Looareesuwan Sornchai, Fiona E Lovegrove, Krudsood, Srivicha, John Chandy C., Rajwans, Nimerta, Opoka, Robert, Noppadon Tangpukdee, Hawkes Michael, Lafferty Erin I., Lovegrove Fiona E., Kain, Kevin C, Looareesuwan, Sornchai, Lovegrove, Fiona E., Opoka Robert O., Krudsood Srivicha, Kain, Kevin C., Erin I Lafferty, Kain Kevin C., Robert O Opoka, Lovegrove, Fiona E, Rajwans Nimerta, John, Chandy C., W Conrad Liles, Liles, W. Conrad, Tangpukdee Noppadon, Liles, W Conrad, Chandy C John, Opoka, Robert O, Liles W. Conrad   +38 more
core   +1 more source

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source

Acidosis in severe childhood malaria [PDF]

QJM, 1997
Data were prospectively collected on 306 Kenyan children, including blood gases in 258 (75%). Severe malaria caused a predominantly high-anion-gap metabolic acidosis in at least 43% of children. Children with coma and respiratory distress (CM + RD) had greater evidence of renal dysfunction, lower mean pH and higher mean plasma osmolality than those ...
English, M., Sauerwein, R.W., Waruiru, C., Mosobo, M., Obiero, J., Lowe, B., Marsh, K.   +6 more
openaire   +5 more sources

Serum Angiopoietin-1 and -2 and VEGF are associated with severe disease in vivax malaria

Journal of Vector Borne Diseases, 2020
Background & objectives: Malaria continues to be a significant public health problem in tropical countries including India; however, there are limited tools to predict occurrence of severe disease due to malaria.
Srinivas H Gowda, Hiren Anghan, Hridesh Mishra, Kunzang Chosdol, Manasvini Bhatt, Vinod Kumar, Piyush Ranjan, Praveen Aggarwal, Naveet Wig, Manish Soneja   +9 more
doaj   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

The ABO blood group and Plasmodium falciparum malaria in Awash, Metehara and Ziway areas, Ethiopia

Malaria Journal, 2010
Background The virulence of Plasmodium falciparum is associated with the capacity of the infected red blood cell (iRBC) to adhere to uninfected RBCs, a process known as rosetting, which has been linked to the occurrence of severe malaria.
Tekeste Zinaye, Petros Beyene
doaj   +1 more source

CR1 Knops blood group alleles are not associated with severe malaria in the Gambia [PDF]

, 2003
The Knops blood group antigen erythrocyte polymorphisms have been associated with reduced falciparum malaria-based in vitro rosette formation (putative malaria virulence factor).
D T McNamara, McNamara, D T, Moulds, JM, Kasehagen, LJ, Zimmerman, P A, J Alexandra Rowe, Hill, Adrian, Zimmerman, PA, McNamara, DT, A V S Hill, Fitness, J, P A Zimmerman, J M Moulds, Moulds, J M, Rowe, J Alexandra; id_orcid, Hill, A V S, L J Kasehagen, J Fitness, Kasehagen, L J, Rowe, JA, Hill, AV   +20 more
core   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source