Results 91 to 100 of about 110,606 (268)

Bayesian Model Averaging in Causal Instrumental Variable Models

Journal of Applied Econometrics, EarlyView.
ABSTRACT Instrumental variables are a popular tool to infer causal effects under unobserved confounding, but choosing suitable instruments is challenging in practice. We propose gIVBMA, a Bayesian model averaging procedure that addresses this challenge by averaging across different sets of instrumental variables and covariates in a structural equation ...
Gregor Steiner, Mark Steel
wiley   +1 more source

Admission Diagnosis of Cerebral Malaria in Adults in an Endemic Area of Tanzania:Implications and Clinical Description [PDF]

, 2003
Cerebralmalariais commonly diagnosed in adults in endemic areas in Africa, both in hospitals and in the community. This presents a paradox inconsistent with the epidemiological understanding that the development of immunity during childhood confers ...
Liyombo, E, Matuja, W, Snow, RW, Makani, J, Snow, R. W, Marsh, K, Warrell, D, Makani, Julie, Marsh, Kevin, Snow, Robert, Warrell, DA   +10 more
core   +1 more source

Beyond Skin and Eyes: The Medical and Social Burden of Oculocutaneous Albinism in Africa: A Narrative Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Oculocutaneous albinism (OCA) is a genetic disorder found worldwide, but its impact is particularly pronounced in the African continent. This results from both a higher prevalence and the persistent myths and superstitions surrounding the condition in many African communities.
Rebecca Donadoni, Niccolò Capurro, Alessandro Svizzero, Valeria Brazzelli   +3 more
wiley   +1 more source

Deubiquitinase USP38 Stabilizes PLK1 Expression to Boost DNA Damage Repair in Ovarian Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ovarian cancer (OC) is one of the most prevalent and severe gynecological malignant tumors. DNA damage repair (DDR) is essential in maintaining genome stability. This study aims to investigate the effects and mechanisms of USP38 and PLK1 on DNA damage repair and malignant behavior in OC cells.
Yuan Ma, Ying Li, Kai‐Li Li
wiley   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Impact of Malaria Severity on Serum Levels of Hepcidin and Iron Status in Children

Online Journal of Health & Allied Sciences, 2019
Malaria is a life threatening disease and one of the leading causes of death in Africa especially in children. This study aimed to assess the impact of malaria on levels of hepcidin and iron status (haemoglobin, serum iron and total iron binding capacity)
Oluboyo, O. Adeola, Iwuchukwu Theodora, Oluboyo, O. Bernard, Olayanju, O. Ayodeji   +3 more
doaj  

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Effect of α(+)-Thalassaemia on Episodes of Fever due to Malaria and Other Causes: A Community-Based Cohort Study in Tanzania. [PDF]

, 2011
It is controversial to what degree α(+)-thalassaemia protects against episodes of uncomplicated malaria and febrile disease due to infections other than Plasmodium. In Tanzania, in children aged 6-60 months and height-for-age z-score < -1.5 SD (n = 612),
Veenemans, J., Veenemans, Jacobien, Mbugi Erasto V, Huub FJ Savelkoul, Savelkoul, H.F.J., Demir, Ayşe Y, Savelkoul, Huub FJ, Hans Verhoef, Baidjoe, Amrish Y, Esther JS Jansen, Amrish Y Baidjoe, Kraaijenhagen, Rob J, Jansen Esther JS, Savelkoul, Huub F J, Veenemans Jacobien, Demir Ayşe Y, Mbugi, Erasto V, Rob J Kraaijenhagen, Savelkoul, H.F.J, Baidjoe, A.Y., Verhoef, H., Verhoef Hans, Kraaijenhagen Rob J, Erasto V Mbugi, Jansen, Esther JS, Savelkoul Huub FJ, Ayşe Y Demir, Baidjoe Amrish Y, Jansen, E.J.S., Mbugi, E.V., Jacobien Veenemans, Verhoef, Hans, Jansen, Esther J S, Demir, A.Y., Kraaijenhagen, R.J.   +34 more
core   +1 more source

Malaria in rural Mozambique. Part II: children admitted to hospital

Malaria Journal, 2008
Background Characterization of severe malaria cases on arrival to hospital may lead to early recognition and improved management. Minimum community based-incidence rates (MCBIRs) complement hospital data, describing the malaria burden in the community ...
Macete Eusébio, Nhacolo Ariel, Bardají Azucena, Nhampossa Tacilta, Sacarlal Jahit, Aide Pedro, Sigaúque Betuel, Guinovart Caterina, Bassat Quique, Mandomando Inácio, Aponte John J, Menéndez Clara, Alonso Pedro L   +12 more
doaj   +1 more source

The Mexico City Policy in US Development Policy and Its Backlash‐Frontlash‐Logic

Public Administration and Development, EarlyView.
ABSTRACT The Mexico City Policy provides for the discontinuation of U.S. government funding for foreign non‐governmental organizations (NGOs) that provide legal abortion services. While Republican administrations have repeatedly pushed for the introduction of the Mexico City Policy after their re‐election, those regulations have been rescinded by ...
Thomas Lange
wiley   +1 more source