Results 71 to 80 of about 110,606 (268)

Xanthine oxidase levels and immune dysregulation are independently associated with anemia in Plasmodium falciparum malaria

Scientific Reports, 2023
Severe anemia is an important contributor to mortality in children with severe malaria. Anemia in malaria is a multi-factorial complication, since dyserythropoiesis, hemolysis and phagocytic clearance of uninfected red blood cells (RBCs) can contribute ...
Marilyn Vasquez, Margaux Sica, Ruth Namazzi, Robert O. Opoka, Julian Sherman, Dibyadyuti Datta, Miquel Duran-Frigola, John M. Ssenkusu, Chandy C. John, Andrea L. Conroy, Ana Rodriguez   +10 more
doaj   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

Morbidity from malaria in children in the year after they had received intermittent preventive treatment of malaria: a randomised trial. [PDF]

, 2011
BACKGROUND: Interventions that reduce exposure to malaria infection may lead to delayed malaria morbidity and mortality. We investigated whether intermittent preventive treatment of malaria in children (IPTc) was associated with an increase in the ...
Issa N Ouédraogo, Greenwood, Brian M, Amadou T. Konaté, Tiono, Alfred B, Amidou Z Ouédraogo, Kangoyé, David T, Youssouf Kaboré, Daniel Chandramohan, Ouédraogo, Amidou Z, Soulama, Issiaka, Sirima, Sodiomon B, Issa N. Ouédraogo, Diarra, Amidou, Ouédraogo, Issa N, Amadou T Konaté, Paul J. Milligan, Sodiomon B. Sirima, Yaro, Jean Baptiste, Milligan, Paul J, Gansané, Adama, Alphonse Ouédraogo, Simon Cousens, Alfred B. Tiono, Diallo, Diadier A, Jean Baptiste Yaro, Diadier A. Diallo, Espérance Ouédraogo, Amidou Z. Ouédraogo, Ouédraogo, Alphonse, Adama Gansané, Cousens, Simon, Diadier A Diallo, Alfred B Tiono, Sodiomon B Sirima, David T. Kangoyé, Ouédraogo, Espérance, Chandramohan, Daniel, David T Kangoyé, Paul J Milligan, Issiaka Soulama, Brian M Greenwood, Amidou Diarra, Konaté, Amadou T, Brian M. Greenwood, Kaboré, Youssouf   +44 more
core   +1 more source

Nanophotonic Biosensors and the Paradigm of Trans‐Scale Autonomous Bio‐Integrated Diagnostics for Addressing Health Complexities

Electron, EarlyView.
Physics‐driven advances in optical nanobiosensors for rapid, miniaturized, and point‐of‐care diagnostics for next‐generation decentralized and personalized healthcare based on sensor intelligence. ABSTRACT Public health emergencies and the escalating burden of chronic diseases necessitate a paradigm shift from centralized laboratory testing to rapid ...
Vishal Chaudhary, Harsh Sable, Sonu Sonu, Lakshita Phor, Reddicherla Umapathi, Pradeep Bhadola   +5 more
wiley   +1 more source

Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis. [PDF]

, 2010
With the functional demonstration of a role in erythrocyte invasion by Plasmodium falciparum parasites, implications in the aetiology of common conditions that prevail in individuals of African origin, and a wealth of pharmacological knowledge, the ...
Jallow, Muminatou, Andrew E Fry, Angela Green, Taylor Terrie E., Haldar, Kasturi, Diakite, M, Haldar Kasturi, Kirk A Rockett, Kwiatkowski, DP, Taylor, Terrie E, Richardson, Anna, Fry, AE, Green, A, Kwiatkowski, Dominic, Sisay-Joof, Fatou, Dominic P Kwiatkowski, Kwiatkowski Dominic P., Taane G Clark, Pinder Margaret, Rockett, KA, Sisay-Joof, F, Molyneux, ME, Kasturi Haldar, Mahamadou Diakite, Sisay-Joof Fatou, Green Angela, Haldar, K, Campino, S, Auburn Sarah, Clark, Taane G, Clark, TG, Fry Andrew E., Molyneux, Malcolm E, Green, Angela, Campino Susana, Molyneux Malcolm E., Auburn, Sarah, Fatou Sisay-Joof, Pinder, M, Auburn, S, Susana Campino, Sarah Auburn, Diakite, Mahamadou, Rockett, Kirk A, Richardson, A, Muminatou Jallow, Fry, Andrew E, Richardson Anna, Jallow Muminatou, Anna Richardson, Jallow, M, Malcolm E Molyneux, Campino, Susana, Diakite Mahamadou, Rockett Kirk A., Clark Taane G., Taylor, TE, Margaret Pinder, Terrie E Taylor, Pinder, Margaret, Kwiatkowski, Dominic P   +60 more
core   +1 more source

Quantitative electroencephalographic measures during postmalarial epileptogenesis

Epilepsia, EarlyView.
Abstract Objective Severe malaria with neurologic involvement contributes significantly to the global burden of acquired pediatric epilepsy. We studied quantitative electroencephalographic (EEG) measures in postmalarial epileptogenesis. Methods A total of 186 patients, aged 6 months to 11 years, with confirmed central nervous system malaria were ...
Rasesh B. Joshi, Suzanna Mwanza, Hitten P. Zaveri, Joseph Kasolo, Angela Masempela, Thelma Musakanya, Tina Mwale, Violet Nambeye, Rosemary Nyriongo, Ruth A. Tembo, Christopher Cortina, Bo Zhang, Gretchen L. Birbeck, Alexander Rotenberg, Archana A. Patel   +14 more
wiley   +1 more source

Genetic diversity of expressed Plasmodium falciparum var genes from Tanzanian children with severe malaria [PDF]

, 2012
BACKGROUND: Severe malaria has been attributed to the expression of a restricted subset of the var multi-gene family, which encodes for Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).
Rottman, Matthias, Beck, Hans-Peter, Beck, H. P., Rottmann, M., Beck Hans-Peter, Mugasa, Joseph, Rusch, Sebastian, Rottmann, Matthias, Mugasa, J., Qi, W., Qi Weihong, Qi, Weihong, Rusch, S., Rusch Sebastian, Rottmann Matthias, Mugasa Joseph   +15 more
core   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Case-control approach to identify Plasmodium falciparum polymorphisms associated with severe malaria. [PDF]

, 2009
BACKGROUND: Studies to identify phenotypically-associated polymorphisms in the Plasmodium falciparum 23 Mb genome will require a dense array of marker loci.
David J Conway, Conway, David J, Chokejindachai, Watcharee, Watcharee Chokejindachai   +3 more
core   +1 more source

An epidemiological analysis of severe imported malaria infections in Sri Lanka, after malaria elimination

Malaria Journal
Background Imported malaria continues to be reported in Sri Lanka after it was eliminated in 2012, and a few progress to life-threatening severe malaria.
Shilanthi Seneviratne, Deepika Fernando, Rajitha Wickremasinghe, Sujai Senarathne, Pubudu Chulasiri, Nethmini Thenuwara, Champa Aluthweera, Iromi Mohotti, Shamila Jayakuru, Thilan Fernando, Anula Wijesundara, Rohini Fernandopulle, Kamini Mendis   +12 more
doaj   +1 more source