Results 51 to 60 of about 110,606 (268)

Assessment of perinatal outcomes of pregnant women with severe versus simple malaria.

PLoS ONE, 2021
ObjectiveMalaria in pregnancy is associated with adverse perinatal outcomes. The objective was to compare outcomes of simple and severe malaria and to determine whether they vary by trimester or severity of infection.MethodsProspective cohort study ...
Alfred Kwizera, Diomede Ntasumumuyange, Maria Small, Stephen Rulisa, Alexandra N Moscovitz, Urania Magriples   +5 more
doaj   +1 more source

Relation between Increased IL-10 Levels and Malaria Severity: A Systematic Review and Meta-Analysis

Tropical Medicine and Infectious Disease, 2023
The roles of anti-inflammatory cytokines in the pathogenesis of severe malaria have been widely studied, and the role of IL-10 in the pathogenesis of severe malaria remains unclear.
Phoomjai Sornsenee, Polrat Wilairatana, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay, Chonticha Romyasamit, Manas Kotepui   +5 more
doaj   +1 more source

A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

Advanced Science, EarlyView.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu, Ting Wang, Jietao Liu, Jiacheng Qin, Bin Yang, Yihang Liu, Pengfei Li, Gaoxue Wang, Fei Ling   +8 more
wiley   +1 more source

Treatment guided by rapid diagnostic tests for malaria in Tanzanian children: safety and alternative bacterial diagnoses. [PDF]

, 2011
BACKGROUND: WHO guidelines for the treatment of young children with suspected malaria have recently changed from presumptive treatment to anti-malarial treatment guided by a blood slide or malaria rapid diagnostic test (RDT).
Christopher JM Whitty, Mrema, H, Manjurano Alphaxard, Mandia Victor, Manjurano, A, Amos, Ben, Manjurano, Alphaxard, Mandia, V, Muro, F, Florida Muro, Alma Sykes, Sykes, Alma, Whitty, Christopher JM, Mandia, Victor, Mtove, G, Amos, B, Hedwiga Mrema, Victor Mandia, Hendriksen, ICE, George Mtove, Whitty Christopher JM, Helena Hildenwall, Mrema, Hedwiga, Whitty, CJM, Hendriksen Ilse CE, Hildenwall, H,, Hildenwall Helena, Muro, Florida, Hendriksen, Ilse Ce, Hugh Reyburn, Muro Florida, Mrema Hedwiga, Reyburn Hugh, Reyburn, Hugh, Alphaxard Manjurano, Mtove George, Sykes, A, Sykes Alma, Hildenwall, Helena, Amos Ben, Mtove, George, Ilse CE Hendriksen, Ben Amos   +42 more
core   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

HMOX1 gene promoter alleles and high HO-1 levels are associated with severe malaria in Gambian children. [PDF]

, 2012
Heme oxygenase 1 (HO-1) is an essential enzyme induced by heme and multiple stimuli associated with critical illness. In humans, polymorphisms in the HMOX1 gene promoter may influence the magnitude of HO-1 expression.
Madi Njie (177625), Walther, Brigitte, Cunnington, A., De Caul, A, Sebastian Weis, Ebonyi, A., Deininger Susanne, Aka Peter, Deininger, S., Peter Aka, Takem, Ebako N, Predazzi, Irene M, Conway David J., Predazzi, IM, Cunnington, Aubrey, Walther, Michael, Conway, DJ, Aubrey Cunnington, Njie, M., Predazzi, I. M., Weis Sebastian, Augustine Ebonyi (177659), Sarah Rowland-Jones, Walther Michael, Amambua-Ngwa, A., Sarah Rowland-Jones (74678), Scott M. Williams (177668), Robert Walton, Susanne Deininger (173844), Sirugo, G, Cunnington Aubrey, Njie, Madi, Williams Scott M., Sirugo, Giorgio, Weis, S, Augustine Ebonyi, Walton Robert, Aka, P, Aka, P., Rowland-Jones Sarah, Williams, Scott M, Williams, S. M., Ebonyi, A, Alfred Amambua-Ngwa (122336), Weis, Sebastian, De Caul, Adam, Williams, SM, Sebastian Weis (161447), Amambua-Ngwa Alfred, Takem Ebako N., Deininger, Susanne, Adam De Caul (177612), Giorgio Sirugo, Ebako N. Takem (177656), Amambua-Ngwa, A, Walton, Robert T., Ebonyi, Augustine, Alfred Amambua-Ngwa, Madi Njie, Michael Walther, Rowland-Jones, S., Giorgio Sirugo (62489), Aka, Peter, Walton, R, Njie, M, De Caul Adam, Njie Madi, Rowland-Jones, Sarah, Takem, EN, Predazzi Irene M., Takem, E. N., Robert Walton (177664), Amambua-Ngwa, Alfred, Conway, D. J., Adam De Caul, Walther, B., Weis, S., Deininger, S, Susanne Deininger, Aubrey Cunnington (177640), Conway, David J, Peter Aka (177618), Sirugo, G., Ebako N Takem, David J Conway, David J. Conway (34880), de Caul, A., Irene M. Predazzi (177634), Brigitte Walther (130764), Walther, M, Walther, M., Walther Brigitte, Walton, Robert, Cunnington, A, Scott M Williams, Irene M Predazzi, Sirugo Giorgio, Walther, B, Rowland-Jones, S, Brigitte Walther, Michael Walther (130767), Ebonyi Augustine   +101 more
core   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Transforming growth factor beta 2 and heme oxygenase 1 genes are risk factors for the cerebral malaria syndrome in Angolan children. [PDF]

, 2010
BACKGROUND: Cerebral malaria (CM) represents a severe outcome of the Plasmodium falciparum infection. Recent genetic studies have correlated human genes with severe malaria susceptibility, but there is little data on genetic variants that increase the ...
Sambo, Maria Rosário, Carla Benchimol, Marques, Maria Isabel, Nuno Sepúlveda, Carlos Penha-Gonçalves, Maria Rosário Sambo, Maria Isabel Marques, Stefan Mustafa, Sepúlveda, Nuno, Sepúlveda Nuno, Gonçalves Lígia, Trovoada, Maria Jesus, Mustafa Stefan, Rute Velosa, Marques Maria Isabel, Velosa, Rute, António Coutinho, Benchimol, Carla, Vatúsia Quinhentos, Sambo Maria Rosário, Quinhentos Vatúsia, Oswald Wagner, Taane G Clark, Benchimol Carla, Penha-Gonçalves Carlos, Penha-Gonçalves, Carlos, Gonçalves, Lígia, Mustafa, Stefan, Coutinho, António, Maria Jesus Trovoada, Coutinho António, Clark Taane G., Lígia Gonçalves, Trovoada Maria Jesus, Quinhentos, Vatúsia, Wagner, Oswald, Wagner Oswald, Taane G. Clark, Clark, Taane G, Velosa Rute   +39 more
core   +1 more source

Severe imported malaria in a Serbian referral center [PDF]

Vojnosanitetski Pregled, 2019
Background/Aim. The World Health Organization estimates that 3.2 billion people are at a risk of being infected with malaria. Thus, the adequate diagnostic protocols for malaria, especially those aimed at determining disease severity, are paramount both ...
Poluga Jasmina, Karić Uroš, Dakić Zorica, Katanić Nataša, Lavadinović Lidija, Milošević Branko, Nikolić Nataša, Urošević Aleksandar, Jegorović Boris, Pavlović Milorad   +9 more
doaj   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source