Results 51 to 60 of about 235,554 (306)

Relation between Increased IL-10 Levels and Malaria Severity: A Systematic Review and Meta-Analysis

Tropical Medicine and Infectious Disease, 2023
The roles of anti-inflammatory cytokines in the pathogenesis of severe malaria have been widely studied, and the role of IL-10 in the pathogenesis of severe malaria remains unclear.
Phoomjai Sornsenee, Polrat Wilairatana, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay, Chonticha Romyasamit, Manas Kotepui   +5 more
doaj   +1 more source

Inter-Relationships of Cardinal Features and Outcomes of Symptomatic Pediatric Plasmodium falciparum Malaria in 1,933 Children in Kampala, Uganda [PDF]

, 2013
Malaria remains a challenging diagnosis with variable clinical presentation and a wide spectrum of disease severity. Using a structured case report form, we prospectively assessed 1,933 children at Mulago Hospital in Kampala, Uganda with acute Plasmodium
Cserti-Gazdewich, Christine M., Ddungu, Henry, Dhabangi, Aggrey, Dzik, Walter Henry, Mpimbaza, Arthur, Musoke, Charles, Nabukeera-Barungi, Nicolette, Nakiboneka-Ssenabulya, Deborah, Ssewanyana, Isaac   +8 more
core   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis. [PDF]

, 2015
Inhibition of nitric oxide (NO) signaling may contribute to pathological activation of the vascular endothelium during severe malaria infection. Dimethylarginine dimethylaminohydrolase (DDAH) regulates endothelial NO synthesis by maintaining homeostasis ...
Ackerman, H, Alkaitis, MS, Billker, O, Casals-Pascual, C, Chertow, JH, Conway, DJ, Correa, S, Cunnington, AJ, Ebonyi, AO, Ikeda, AK, Jayasooriya, S, Nardone, G, Njie, M, Okebe, J, Walther, M   +14 more
core   +9 more sources

Prevalence and risk factors related to poor outcome of patients with severe Plasmodium vivax infection: a systematic review, meta-analysis, and analysis of case reports

BMC Infectious Diseases, 2020
Background Plasmodium vivax rarely develops severe complications when compared to severe falciparum malaria. However, severe vivax malaria also needs urgent, intensive care and treatment as severe falciparum malaria.
Manas Kotepui, Kwuntida Uthaisar Kotepui, Giovanni De Jesus Milanez, Frederick Ramirez Masangkay   +3 more
doaj   +1 more source

Assessment of perinatal outcomes of pregnant women with severe versus simple malaria.

PLoS ONE, 2021
ObjectiveMalaria in pregnancy is associated with adverse perinatal outcomes. The objective was to compare outcomes of simple and severe malaria and to determine whether they vary by trimester or severity of infection.MethodsProspective cohort study ...
Alfred Kwizera, Diomede Ntasumumuyange, Maria Small, Stephen Rulisa, Alexandra N Moscovitz, Urania Magriples   +5 more
doaj   +1 more source

Molecular basis of severe malaria [PDF]

Proceedings of the National Academy of Sciences, 2012
Malaria is an ancient scourge that continues to plague many regions of the developing world. Despite its long history, many aspects of the disease remain difficult to explain. For example, why some individuals experience relatively mild symptoms and others progress to severe and sometimes lethal disease is not understood. Similarly, the molecular basis
Kirk W, Deitsch, Chetan E, Chitnis
openaire   +2 more sources

Changing pattern of malaria in Bissau, Guinea Bissau.

, 2008
OBJECTIVE: To describe the epidemiology of malaria in Guinea-Bissau, in view of the fact that more funds are available now for malaria control in the country.
Aaby, Peter, Greenwood, Brian, Kofoed, Poul-Erik, Rodrigues, Amabelia, Schellenberg, Joanna Armstrong   +4 more
core   +1 more source

Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM): a trial for children with sickle cell anemia [PDF]

, 2017
Hydroxyurea treatment is recommended for children with sickle cell anemia (SCA) living in high-resource malaria-free regions, but its safety and efficacy in malaria-endemic sub-Saharan Africa, where the greatest sickle-cell burden exists, remain unknown.
Hodges, James S., Hume, Heather A., John, Chandy C., Kasirye, Phillip, Lane, Adam, Latham, Teresa S., Ndugwa, Christopher M., Opoka, Robert O., Ware, Russell E.   +8 more
core   +2 more sources

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source