Results 131 to 140 of about 1,804,243 (315)

The management and treatment of malaria [PDF]

, 1989
Falciparum malaria can create severe complications. Antimalarial drugs such as quinine or chloroquine help in the treatment and management to these complications. The use of chemoprophylaxis is a must for persons travelling abroad to countries subject to
Gilles, Herbert M.
core  

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Severe falciparum malaria in young children of the Kassena-Nankana district of northern Ghana

Malaria Journal, 2007
Study design Severe falciparum malaria in children was studied as part of the characterization of the Kassena-Nankana District Ghana for future malaria vaccine trials.
Anto Francis, Ansah Akosua, Anyorigiya Thomas, Ansah Patrick, Atuguba Frank, Rogers William, Koram Kwadwo A, Oduro Abraham R, Mensah Nathan, Hodgson Abraham, Nkrumah Francis   +10 more
doaj   +1 more source

Estimating the potential public health impact of seasonal malaria chemoprevention in African children. [PDF]

, 2012
Seasonal malaria chemoprevention, previously known as intermittent preventive treatment in children, is highly effective in areas with a short malaria transmission season.
Greenwood, Brian M, Roca-Feltrer, A., Ghani, Azra C, Cairns, M., Garske, Tini, Diallo, Diadier, Wilson, Anne L, Ghani, A.C., Greenwood, B.M., Milligan, Paul J, Diallo, D., Roca-Feltrer, Arantxa, Wilson, A.L., Milligan, P.J., Garske, T., Cairns, Matthew   +15 more
core   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Comparative assessment of clinic-laboratory profile of different species of severe malaria in a tertiary care institute in southern India

Journal of Vector Borne Diseases, 2019
Background & objectives: Majority of the studies on severe malaria in India have concentrated on falciparum and have been done in northern part.
Thomas Kuncheria, Nithyananda K Chowta, Deepak Madi, Mukta N Chowta, A Basavaprabhu   +4 more
doaj  

The effect of alpha+-thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya.

PLoS Medicine, 2006
BackgroundThe alpha-thalassaemias are the commonest genetic disorders of humans. It is generally believed that this high frequency reflects selection through a survival advantage against death from malaria; nevertheless, the epidemiological description ...
Sammy Wambua, Tabitha W Mwangi, Moses Kortok, Sophie M Uyoga, Alex W Macharia, Jedidah K Mwacharo, David J Weatherall, Robert W Snow, Kevin Marsh, Thomas N Williams   +9 more
doaj   +1 more source

Malaria and susceptibility to other infections [PDF]

Malaria is widely perceived as immunosuppressive. Despite extensive phenomenological description, the underlying mechanisms remain poorly described. The aim of this thesis was to identify possible mechanisms by which malaria modifies host defence, and
Cunnington, Aubrey Justin
core   +1 more source

The Changing Epidemiology of Malaria in Ifakara Town, Southern Tanzania. [PDF]

, 2004
Between 1995 and 2000 there were marked changes in the epidemiology of malaria in Ifakara, southern Tanzania. We documented these changes using parasitological and clinical data from a series of community- and hospital-based studies involving children up
Guinovart, Caterina, Alonso, Pedro, Schellenberg, David, Aponte, John, Mshinda, Hassan, Menendez, Clara, Tanner, Marcel   +6 more
core   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source