Results 151 to 160 of about 235,554 (306)
Assessing Risk Thresholds in Controlled Human Infection Models (CHIM)
Bioethics, EarlyView.ABSTRACT Controlled Human Infection Models (CHIMs) are a type of clinical trial involving deliberately exposing human volunteers to an infectious agent. Compared to studies of natural infection, CHIMs offers distinctive benefits, from the ability to study presymptomatic infection to a direct assessment of the efficacy of vaccines and therapeutics in a ...
Alexa Nord‐Bronzyk +4 more
wiley +1 more source
Birth, EarlyView.New analysis from 15 years of Indonesian Demographic Health Survey Data has identified a shift from home birth to hospital birth. However, 65% of women who gave birth in hospital had no risk factors, while 13% of women who gave birth at home did report pregnancy‐related risk factors.
Kai Hodgkin +2 more
wiley +1 more source
Using customs data to understand overlooked trade in non‐CITES birds between Africa and Asia
Conservation Biology, EarlyView.Abstract The international trade in live birds poses risks to animals, people, and biodiversity. To effectively mitigate these risks, decision‐makers require information on the volume, dynamics, and direction of trade. Despite Africa once being the largest exporter of birds by region, very little data exist on recent trade in live birds not listed on ...
Alisa Davies +4 more
wiley +1 more source
Management of severe falciparum malaria.
Journal of postgraduate medicine, 2004 Plasmodium falciparum is the most common cause of severe and life-threatening malaria. Falciparum malaria causes over one million deaths every year. In Africa, a vast majority of these deaths occur in children under five years of age. The presentation of severe malaria varies with age and geographical distribution.
Njuguna, PW, Newton, CRJC
openaire +2 more sources
Reframing Justice in Healthcare AI: An Ubuntu‐Based Approach for Africa
Developing World Bioethics, EarlyView.ABSTRACT There is an ongoing debate on how to balance the benefits and risks of artificial intelligence (AI), especially in healthcare. In resource‐constrained settings, such as Africa, where access to quality care remains a challenge, AI has the potential to improve efficiency, accessibility, and patient outcomes.
Aloysius Ochasi +3 more
wiley +1 more source
Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders
The FEBS Journal, EarlyView.Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo +6 more
wiley +1 more source
PEG400 regulates Falcipain 2 activity through an allosteric mechanism
The FEBS Journal, EarlyView.Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath +2 more
wiley +1 more source
Gender, Work &Organization, EarlyView.ABSTRACT The infrastructure of precarious work is racialized and gendered, affecting disenfranchised Black women who carry the burden of low paid caregiving within the healthcare system. In South Africa, Community Health Workers, predominantly Black women from marginalized communities, have been vital in providing primary healthcare services at home ...
Sivuyisiwe Wonci
wiley +1 more source