Results 141 to 150 of about 5,229,135 (336)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Toll-Like Receptor 4 Polymorphisms (896A/G and 1196C/T) as an Indicator of COVID-19 Severity in a Convenience Sample of Egyptian Patients

Journal of Inflammation Research, 2021
Sara I Taha,1 Aalaa K Shata,2 Shereen A Baioumy,3 Shaimaa H Fouad,4 Sherif G Anis,5 Isis M Mossad,6 Nouran M Moustafa,7,8 Dina M Abdou,9 Mariam K Youssef1 1Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt ...
Taha SI, Shata AK, Baioumy SA, Fouad SH, Anis SG, Mossad IM, Moustafa NM, Abdou DM, Youssef MK   +8 more
doaj  

Developing Measures of Severity and Frequency of Reconviction [PDF]

, 2005
This report examines the scope for focusing on the seriousness and frequency of recidivism and presents methodology for determining how to measure offence seriousness, and how to measure frequency of offending.
Cutajar Bezzina, Audrienne, Francis, Brian, Humphreys, Leslie, Soothill, Keith   +3 more
core  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

The systemic immune-inflammation index is significantly associated with the severity of silicosis: a 9-year retrospective study in Beijing

Frontiers in Medicine
BackgroundSilicosis shows an increasing trend with the development of new industries. However, the potential biomarkers for predicting the disease severity are lacking.
Han-Yu-Jie Kang, Si-Yu Cao, Shuai Shao, Li-Rong Liang, Zhao-Hui Tong   +4 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Hypertriglyceridemia-Induced Acute Pancreatitis—The Milky Way Constellation—The Seven-Year Experience of a Large Tertiary Centre

Diagnostics
(1) Background: Hypertriglyceridemia (HTG) is a well-known metabolic condition associated with an increased risk of acute pancreatitis. In this study, we tried to establish whether there are any significant disparities concerning recurrence rate ...
Andrei Vicențiu Edu, Mihai Radu Pahomeanu, Andreea Irina Ghiță, Dalia Ioana Constantinescu, Daniela Gabriela Grigore, Andreea Daniela Bota, Daniela Maria Luta-Dumitrașcu, Cristian George Țieranu, Lucian Negreanu   +8 more
doaj   +1 more source

Severity of Work Disability and Work [PDF]

This paper analyzes the effect of severity of disability on labour force participation by using a self-reported work limitation scale. A dynamic labour force participation model is used to capture the feedback effect of past participation on current ...
Oguzoglu, Umut
core  

Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication.

Archives of General Psychiatry, 2005
R. Kessler, W. Chiu, Olga V Demler, K. Merikangas, E. Walters   +4 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source