Results 91 to 100 of about 81,401 (321)

Euthanasia of laboratory mice: Are isoflurane and sevoflurane real alternatives to carbon dioxide?

PLoS ONE, 2018
In the European Union (EU) millions of laboratory mice are used and killed for experimental and other scientific purposes each year. Although controversially discussed, the use of carbon dioxide (CO2) is still permitted for killing rodents according to ...
N. Marquardt, Malte Feja, H. Hünigen, J. Plendl, L. Menken, H. Fink, B. Bert   +6 more
semanticscholar   +1 more source

Dexmedetomidine suppresses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3K/Akt/mTOR pathway

BMC Anesthesiology, 2019
BackgroundSevoflurane, an inhalational general anesthetic, has become one of the most widely used inhalational anesthetics in surgery. However, previous studies have found that sevoflurane anesthesia can trigger an inflammatory response, resulting in ...
Nan Wang, Mingyu Wang
semanticscholar   +1 more source

Sevoflurane inhibits migration and invasion of colorectal cancer cells by regulating microRNA-34a/ADAM10 axis.

Neoplasma (Bratislava), 2019
Sevoflurane is frequently used volatile anesthetic in cancer surgery. It has been suggested that treatment with sevoflurane could suppress migration and invasion of several human cancer cells in vitro.
S. Sun, L. Ren, J. Liu, P. Wang, S. Shan
semanticscholar   +1 more source

Sevoflurane pretreatment attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis through activation of AKT/pim-1 and AKT/GSK3β signaling pathways

Biotechnology & Biotechnological Equipment, 2019
Myocardial ischemia-reperfusion injury (IRI) is a severe trauma which is characterized by inflammatory reaction, oxidative stress and cardiomyocyte apoptosis.
Wensheng Zhao, Tieshan Zhang, Lulu Xu, Yue Yang, Yingchao Wang, Zhenni Jiang   +5 more
doaj   +1 more source

Autophagy Is Involved in the Sevoflurane Anesthesia-Induced Cognitive Dysfunction of Aged Rats. [PDF]

PLoS ONE, 2016
Autophagy is associated with regulation of both the survival and death of neurons, and has been linked to many neurodegenerative diseases. Postoperative cognitive dysfunction is commonly observed in elderly patients following anesthesia, but the ...
Xiaoming Zhang, Youfa Zhou, Mingmin Xu, Gang Chen   +3 more
doaj   +1 more source

Sevoflurane suppresses proliferation by upregulating microRNA-203 in breast cancer cells.

Molecular Medicine Reports, 2018
Rapid proliferation is one of the critical characteristics of breast cancer. However, the underlying regulatory mechanism of breast cancer cell proliferation is largely unclear.
Jiaying Liu, Longqiu Yang, Xia Guo, Guangli Jin, Qi-min Wang, Dongdong Lv, Junli Liu, Qiu Chen, Q. Song, Baolin Li   +9 more
semanticscholar   +1 more source

Cognitive Impairment and Endoplasmic Reticulum Stress Induced by Repeated Short-Term Sevoflurane Exposure in Early Life of Rats

Frontiers in Psychiatry, 2018
Sevoflurane is one of the most commonly used volatile anaesthetics for children, but the safety of prolonged or repeated clinical use of sevoflurane in infants or children is controversial.
Fu-Yi Shen, Ying-Cai Song, Fei Guo, Zhen-Dong Xu, Qian Li, Bing Zhang, Bing Zhang, Bing Zhang, Yu-Qin Ma, Yu-Qin Ma, Yue-Qi Zhang, Rong Lin, Yang Li, Zhi-Qiang Liu   +13 more
doaj   +1 more source

Sevoflurane post-conditioning attenuates traumatic brain injury-induced neuronal apoptosis by promoting autophagy via the PI3K/AKT signaling pathway

Drug Design, Development and Therapy, 2018
Background Sevoflurane post-conditioning exerts nerve-protective effects through inhibiting caspase-dependent neuronal apoptosis after a traumatic brain injury (TBI).
Hefan He, Wei-feng Liu, Ying-ying Zhou, Yibin Liu, Pei-qing Weng, Yasong Li, Huangde Fu   +6 more
semanticscholar   +1 more source

Effects of sevoflurane exposure on proliferation and differentiation of primary oligodendrocytes

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To investigate the effects of multiple sevoflurane exposures on the proliferation and differentiation of primary oligodendrocytes.Methods·Oligodendrocyte precursor cells (OPCs) were extracted from the cortex of rats on the day of birth and ...
SHI Lingling, CHENG Yanyong, ZHANG Lei
doaj   +1 more source

There are no dragons: Low-flow anaesthesia with sevoflurane is safe

Anaesthesia and Intensive Care, 2019
In this issue of Anaesthesia and Intensive Care, McGain et al. report the results of a survey of inhalational anaesthesia practice in Australia and New Zealand.
R Ross Kennedy, Jan FA Hendrickx, Jeffrey M. Feldman   +2 more
semanticscholar   +1 more source