Results 81 to 90 of about 2,162 (133)

Swimming Exercise Pretreatment Attenuates Postoperative Delirium‐Like Behavior in Type 2 Diabetic Rats by Enhancing Mitochondrial Biogenesis Through Activation of SIRT2 Deacetylation

MedComm, Volume 6, Issue 4, April 2025.
The reduction of SIRT2 following orthopedic surgery in the hippocampus of T2DM rats inhibits the acetylation process of PGC‐1α and the subsequent mitochondrial biogenesis process, leading to mitochondrial dysfunction and postoperative delirium‐like behavior.
Kaixi Liu, Lei Chen, Xinning Mi, Qian Wang, Yitong Li, Jingshu Hong, Xiaoxiao Wang, Yue Li, Yanan Song, Yi Yuan, Jie Wang, Dengyang Han, Taotao Liu, Ning Yang, Xiangyang Guo, Zhengqian Li   +15 more
wiley   +1 more source

DNMT3a Deficiency Contributes to Anesthesia/Surgery‐Induced Synaptic Dysfunction and Cognitive Impairment in Aged Mice

Aging Cell, Volume 24, Issue 4, April 2025.
DNMT3a downregulation appears to causally contribute to surgery‐induced cognitive impairment, whereas its overexpression effectively alleviated cognitive impairment behaviors. Mechanistically, DNMT3a downregulation induced by anesthesia/surgery could disrupt DNA methylation stability in the hippocampus of aged mice. This decreased the binding of DNMT3a
Peilin Cong, Xinwei Huang, Qian Zhang, Mengfan He, Hanxi Wan, Qianqian Wu, Huanghui Wu, Yuxin Zhang, Chun Cheng, Li Tian, Lize Xiong   +10 more
wiley   +1 more source

Total intravenous or inhalational volatile anaesthesia and survival after colorectal cancer surgery: a Swedish national registry study

Anaesthesia, Volume 80, Issue 4, Page 386-394, April 2025.
Summary Introduction Retrospective studies suggest that inhalational volatile anaesthetic agents may contribute to an increased risk of metastasis and reduction in survival rates when used during cancer surgery. This relationship may vary between cancer types due to different tumour biology and differences in surgical procedures.
Anna Enlund, Maziar Nikberg, Anders Berglund, Erland Östberg, Mats Enlund   +4 more
wiley   +1 more source

TRPC4 Mediates Trigeminal Neuropathic Pain via Ca2+‐ERK/P38‐ATF2 Pathway in the Trigeminal Ganglion of Mice

CNS Neuroscience &Therapeutics, Volume 31, Issue 4, April 2025.
The specific mechanism of trigeminal neuropathic pain (TNP) is not fully understood. Through the chronic constriction of the unilateral infraobital nerve (CION) mouse model, we found that nerve compression injury leads to increased expression levels of TRPC4, a sensory neuron in the trigeminal ganglion.
Xinlong Ke, Huajing Cai, Fangla Luo, Xing Zheng, Qian Hu, Youfa Zhou, Yongjie Wang, Xiangnan Zhang, Yeru Chen, Gang Chen   +9 more
wiley   +1 more source

Sevoflurane and analgesia [PDF]

British Journal of Anaesthesia, 2007
S. Grover, D.J. Wilkinson, S.T. Yeo, A. Holdcroft, S.M. Yentis   +4 more
openaire   +3 more sources

Sevoflurane Inhibits the Proliferation of Neural Precursor Cells and Neural Migration of Mice by Inducing Iron Metabolism Disorders

CNS Neuroscience &Therapeutics, Volume 31, Issue 4, April 2025.
Sevoflurane inhibits the proliferation of neural precursor cells and neural migration of embryo brain in mice by inducing iron metabolism disorders. Maintaining iron homeostasis may be an effective strategy for treating Sev‐induced cortical dysplasia.
Xincheng Li, Runjiao Cheng, Mahammad Naeem, Xiaoou Nie, Jiaqi Wang, Liqiang Zhao, Xiaopeng Liu, Zhenhua Shi, Jianhua Zhang   +8 more
wiley   +1 more source

Repeated Exposure to Sevoflurane in Neonatal Mice Induces Cognitive and Synaptic Impairments in a TTLL6‐Mediated Tubulin Polyglutamylation Manner

CNS Neuroscience &Therapeutics, Volume 31, Issue 4, April 2025.
Our findings suggest that sevoflurane treatment in neonatal mice may cause cognitive impairment by altering dendritic spine density and maturation in the CA3 region of the hippocampus. This effect is mediated by TTLL6‐induced tubulin polyglutamylation and Spastin overexpression, driven by Tau phosphorylation and missorting from axons to the ...
Yang Yu, Yue Zhao, Jingyu Feng, Naqi Lian, Jiafeng Yu, Yongyan Yang, Junyan Yao, Yonghao Yu   +7 more
wiley   +1 more source

A comparative study of induction, maintenance and recovery characteristics of sevoflurane and halothane anaesthesia in pediatric patients (6 months to 6 years)

Journal of Anaesthesiology Clinical Pharmacology, 2010
Patients & Methods: In a randomized , double blind clinical study, we studied 30 children, aged 6 months to 6 years, to compare halothane and sevoflurane anaesthesia in patients undergoing short surgical procedures under general anaesthesia.
Shruti Redhu, Gopal Krishan Jalwal, M Saxena, O P Shrivastava   +3 more
doaj  

Determination of Minimum Alveolar Concentrations of Isoflurane and Effective Plasma Concentration of Propofol in Common Marmosets (Callithrix jacchus)

Journal of Medical Primatology, Volume 54, Issue 2, April 2025.
ABSTRACT Background Common marmosets (Callithrix jacchus) have been widely used as laboratory animals; However, limited sedation and anesthetic protocols have yet to be established. In this study, the minimum alveolar concentration of an inhalant (isoflurane) and effective predicted plasma concentration of an injectable anesthetic (propofol) were ...
Kanako Muta, Makoto Koizumi, Takako Miyabe‐Nishiwaki, Yusuke Sotomaru, Asako Nobukiyo, Hiroki Ohta, Hirotaka James Okano, Masatoshi Kamata, Dai Nagakubo, Ryohei Nishimura   +9 more
wiley   +1 more source

Sevoflurane vaporizers [PDF]

Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 1999
J, Ngan, D, Cashen, G, Nichols
openaire   +2 more sources