Results 91 to 100 of about 4,240,671 (271)

Identification of the Sex-Biased Gene Expression and Putative Sex-Associated Genes in Eucommia ulmoides Oliver Using Comparative Transcriptome Analyses

Molecules, 2017
Eucommia ulmoides is a model representative of the dioecious plants with sex differentiation at initiation. Nevertheless, the genetic mechanisms of sexual dimorphism and sex determination in E. ulmoides remain poorly understood.
Wencai Wang, Xianzhi Zhang
doaj   +1 more source

Inter- and Intraspecific Variation inDrosophilaGenes with Sex-Biased Expression [PDF]

International Journal of Evolutionary Biology, 2012
Genes with sexually dimorphic expression (sex-biased genes) often evolve rapidly and are thought to make an important contribution to reproductive isolation between species. We examined the molecular evolution of sex-biased genes inDrosophila melanogasterandD. ananassae, which represent two independent lineages within themelanogastergroup. We find that
Müller, Lena, Grath, Sonja, von Heckel, Korbinian, Parsch, John   +3 more
openaire   +2 more sources

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Species and sex-specific chemosensory gene expression in Anopheles coluzzii and An. quadriannulatus antennae

Parasites & Vectors, 2020
Background Olfactory cues drive mosquito behaviors such as host-seeking, locating sugar sources and oviposition. These behaviors can vary between sexes and closely related species.
Giridhar Athrey, Zachary Popkin-Hall, Luciano Veiga Cosme, Willem Takken, Michel Andre Slotman   +4 more
doaj   +1 more source

Prediction of sex-determination mechanisms in avian primordial germ cells using RNA-seq analysis

Scientific Reports, 2022
In birds, sex is determined through cell-autonomous mechanisms and various factors, such as the dosage of DMRT1. While the sex-determination mechanism in gonads is well known, the mechanism in germ cells remains unclear.
Kennosuke Ichikawa, Yoshiaki Nakamura, Hidemasa Bono, Ryo Ezaki, Mei Matsuzaki, Hiroyuki Horiuchi   +5 more
doaj   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

SexAnnoDB, a knowledgebase of sex-specific regulations from multi-omics data of human cancers

Biology of Sex Differences
Background Sexual differences across molecular levels profoundly impact cancer biology and outcomes. Patient gender significantly influences drug responses, with divergent reactions between men and women to the same drugs.
Mengyuan Yang, Yuzhou Feng, Jiajia Liu, Hong Wang, Sijia Wu, Weiling Zhao, Pora Kim, Xiaobo Zhou   +7 more
doaj   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Sex-biased expression of sex-linked transcripts in spiny frogs with homomorphic sex chromosomes

BMC Genomics
Background The accumulation of sexually antagonistic mutations on chromosomes has been favored in driving the evolution of sex chromosomes. However, empirical evidence has been limited to species with heteromorphic sex chromosomes, where the patterns of ...
Yu Xiao, Yun Xia, Xiaomao Zeng
doaj   +1 more source

Positive selection and relaxed purifying selection contribute to rapid evolution of male-biased genes in a dioecious flowering plant

eLife
Sex-biased genes offer insights into the evolution of sexual dimorphism. Sex-biased genes, especially those with male bias, show elevated evolutionary rates of protein sequences driven by positive selection and relaxed purifying selection in animals ...
Lei Zhao, Wei Zhou, Jun He, De-Zhu Li, Hong-Tao Li   +4 more
doaj   +1 more source