Contribution of Sex‐Biased Expressed Genes in Osteoarthritis
Smart MedicineABSTRACT Human osteoarthritis (OA) displays sex‐specific patterns in its clinical presentation. Key features of the disease—such as prevalence, age of onset, progression, and response to treatment—vary between males and females.
Cuicui Wang +7 more
openaire +3 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
An evolutionarily conserved sexual signature in the primate brain. [PDF]
PLoS Genetics, 2008 The question of a potential biological sexual signature in the human brain is a heavily disputed subject. In order to provide further insight into this issue, we used an evolutionary approach to identify genes with sex differences in brain expression ...
Björn Reinius +6 more
doaj +1 more source
Conflict over condition-dependent sex allocation can lead to mixed sex-determination systems [PDF]
, 2014 Theory suggests that genetic conflicts drive turnovers between sex-determining mechanisms, yet these studies only apply to cases where sex allocation is independent of environment or condition.
Kuijper, B +3 more
core +1 more source
Evolutionary dynamics of sex-biased genes expressed in cricket brains and gonads [PDF]
Journal of Evolutionary Biology, 2020 Abstract Sex-biased gene expression, particularly sex-biased expression in the gonad, has been linked to rates of protein sequence evolution (nonsynonymous to synonymous substitutions, dN/dS) in animals. However, in insects, sex-biased expression studies remain centered on a few holometabolous species, and moreover ...
Carrie A. Whittle +2 more
openaire +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Sexual dimorphism and the evolution of sex-biased gene expression in the brown alga ectocarpus
, 2015 Males and females often have marked phenotypic differences, and the expression of these dissimilarities invariably involves sex differences in gene expression.
Luthringer, R. +7 more
core +2 more sources
Selection shapes turnover and magnitude of sex-biased expression in Drosophila gonads
BMC Evolutionary Biology, 2019 Background Sex-biased gene expression is thought to drive the phenotypic differences in males and females in metazoans. Drosophila has served as a primary model for studying male-female differences in gene expression, and its effects on protein sequence ...
Carrie A. Whittle, Cassandra G. Extavour
doaj +1 more source
Sex-biased gene expression during head development in a sexually dimorphic stalk-eyed fly. [PDF]
PLoS ONE, 2013 Stalk-eyed flies (family Diopsidae) are a model system for studying sexual selection due to the elongated and sexually dimorphic eye-stalks found in many species.
Gerald S Wilkinson +3 more
doaj +1 more source
Quality of sex-sampled and sex-biased lncRNAs at the Bmdsx gene locus.
, 2016 (A) Expression pattern of the W chromosome-specific gene, fem. (B) Sex-biased lncRNAs at the Bmdsx gene locus.
Yuqian Wu (549440) +7 more
core +1 more source