Results 61 to 70 of about 4,240,671 (271)

Extensive differential gene expression and regulation by sex in human skeletal muscle

Cell Genomics
Summary: The identification of sex-differential gene regulatory elements is essential for understanding sex-differential patterns of health and disease.
Sarah C. Hanks, Abigail S. Mauger, Arushi Varshney, Dan L. Ciotlos, Nandini Manickam, Narisu Narisu, Alexandria J. Shumway, Peter Orchard, Michael R. Erdos, Michael D. Sweeney, Jeffrey Okamoto, Anne U. Jackson, Heather M. Stringham, Lori L. Bonnycastle, Xiang Zhou, Timo A. Lakka, Karen L. Mohlke, Jaakko Tuomilehto, Markku Laakso, Michael Boehnke, Praveen Sethupathy, Francis S. Collins, Heikki A. Koistinen, Stephen C.J. Parker, Laura J. Scott   +24 more
doaj   +1 more source

Shared sex-biased enhancers.

, 2021
A, B. Venn diagrams showing the number of sex-biased H3K27ac peaks (ΔK27ac) (>2-fold sex difference at FDR 1.5-fold sex difference at FDR 119]. C. Genes from clusters MA and FA (Fig 1A) with matching sex-biased cis regulatory elements in both strains. C6
Tisha Melia (603850), David J. Waxman (8861903), Bryan J. Matthews (9138209)   +2 more
core   +1 more source

Sex-biased gene expression is repeatedly masculinized in asexual females. [PDF]

Nat Commun, 2019
Abstract Males and females feature strikingly different phenotypes, despite sharing most of their genome. A resolution of this apparent paradox is through differential gene expression, whereby genes are expressed at different levels in each sex.
Parker DJ, Bast J, Jalvingh K, Dumas Z, Robinson-Rechavi M, Schwander T.   +5 more
europepmc   +7 more sources

Plasma growth hormone pulses induce male-biased pulsatile chromatin opening and epigenetic regulation in adult mouse liver

eLife, 2023
Sex differences in plasma growth hormone (GH) profiles, pulsatile in males and persistent in females, regulate sex differences in hepatic STAT5 activation linked to sex differences in gene expression and liver disease susceptibility, but little is ...
Andy Rampersaud, Jeannette Connerney, David J Waxman   +2 more
doaj   +1 more source

INBREEDING AND SEX-BIASED GENE FLOW IN THE ANT FORMICA EXSECTA [PDF]

Evolution, 2003
The objective of this study was to assess breeding and dispersal patterns of both males and females in a monogyne (a single queen per colony) population of ants. Monogyny is commonly associated with extensive nuptial flights, presumably leading to considerable gene flow over large areas.
Sundström, L., Keller, L., Chapuisat, M.   +2 more
openaire   +3 more sources

Complement genes contribute sex-biased vulnerability in diverse disorders [PDF]

Nature, 2020
Many common illnesses, for reasons that have not been identified, differentially affect men and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and Sjögren's syndrome affect nine times more women than men1, whereas schizophrenia affects men with greater frequency and severity relative to women2.
Kamitaki, Nolan, Sekar, Aswin, Handsaker, Robert E., de Rivera, Heather, Tooley, Katherine, Morris, David L., Taylor, Kimberly E., Whelan, Christopher W., Tombleson, Philip, Loohuis, Loes M.Olde, Ripke, Stephan, Neale, Benjamin M., Corvin, Aiden, Walters, James T.R., Farh, Kai How, Holmans, Peter A., Lee, Phil, Bulik-Sullivan, Brendan, Collier, David A., Huang, Hailiang, Pers, Tune H., Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W., Bruggeman, Richard, Buccola, Nancy G., Buckner, Randy L., Byerley, William, Cahn, Wiepke, Cai, Guiqing, Cairns, Murray J., Campion, Dominique, Cantor, Rita M., Carr, Vaughan J., Carrera, Noa, Catts, Stanley V., Chambert, Kimberly D., Chan, Raymond C.K., Chen, Ronald Y.L., Chen, Eric Y.H., Cheng, Wei, Cheung, Eric F.C., Chong, Siow Ann, Cloninger, C. Robert, Cohen, David, Cohen, Nadine, Cormican, Paul, Craddock, Nick, Crespo-Facorro, Benedicto, Crowley, James J., Curtis, David, Davidson, Michael, Davis, Kenneth L., Degenhardt, Franziska, Del Favero, Jurgen, DeLisi, Lynn E., Demontis, Ditte, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Dudbridge, Frank, Durmishi, Naser, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Essioux, Laurent, Fanous, Ayman H., Farrell, Martilias S., Frank, Josef, Franke, Lude, Freedman, Robert, Freimer, Nelson B., Friedl, Marion, Friedman, Joseph I., Fromer, Menachem, Genovese, Giulio, Georgieva, Lyudmila, Gershon, Elliot S., Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., Golimbet, Vera, Gopal, Srihari, Gratten, Jacob, de Haan, Lieuwe, Mitjans, Marina, Hamshere, Marian L., Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Hartmann, Annette M., Henskens, Frans A., Herms, Stefan, Hirschhorn, Joel N., Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V., Hougaard, David M., Ikeda, Masashi, Joa, Inge, Julià, Antonio, Kahn, René S., Kalaydjieva, Luba, Karachanak-Yankova, Sena, Karjalainen, Juha, Kavanagh, David, Keller, Matthew C., Kelly, Brian J., Kennedy, James L., Khrunin, Andrey, Kim, Yunjung, Klovins, Janis, Knowles, James A., Konte, Bettina, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kuzelova-Ptackova, Hana, Kähler, Anna K., Laurent, Claudine, Keong, Jimmy Lee Chee, Lee, S. Hong, Legge, Sophie E., Lerer, Bernard, Li, Miaoxin, Li, Tao, Liang, Kung Yee, Lieberman, Jeffrey, Limborska, Svetlana, Loughland, Carmel M., Jan Lubinski, Lubinski, Lönnqvist, Jouko, Macek, Milan, Magnusson, Patrik K.E., Maher, Brion S., Maier, Wolfgang, Mallet, Jacques, Marsal, Sara, Mattheisen, Manuel, Mattingsdal, Morten, McCarley, Robert W., McDonald, Colm, McIntosh, Andrew M., Meier, Sandra, Meijer, Carin J., Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mokrab, Younes, Morris, Derek W., Mors, Ole, Murphy, Kieran C., Murray, Robin M., Myin-Germeys, Inez, Müller-Myhsok, Bertram, Nelis, Mari, Nenadic, Igor, Nertney, Deborah A., Nestadt, Gerald, Nicodemus, Kristin K., Nikitina-Zake, Liene, Nisenbaum, Laura, Nordin, Annelie, O’Callaghan, Eadbhard, O’Dushlaine, Colm, O’Neill, F. Anthony, Oh, Sang Yun, Olincy, Ann, Olsen, Line, Van Os, Jim, Pantelis, Christos, Papadimitriou, George N., Steixner, Agnes A., Parkhomenko, Elena, Pato, Michele T., Paunio, Tiina, Pejovic-Milovancevic, Milica, Perkins, Diana O., Pietiläinen, Olli, Pimm, Jonathan, Pocklington, Andrew J., Powell, John, Price, Alkes, Roussos, Panos, Schall, Ulrich, Scott, Rodney J., Sigurdsson, Engilbert, Sim, Kang, Slominsky, Petr, Stogmann, Elisabeth, Stroup, T. Scott, Tooney, Paul A., Tosato, Sarah, Wang, Qiang, Webb, Bradley T., Zai, Clement C., Wray, Naomi R., Bramon, Elvira, Buxbaum, Joseph D., Cichon, Sven, Liu, Jianjun, McQuillin, Andrew, Mowry, Bryan J., Ophoff, Roel A., Palotie, Aarno, Petryshen, Tracey L., Posthuma, Danielle, Brown, Matthew A., Plomin, Robert, Wood, Nicholas W., Bellenguez, Céline, Giannoulatou, Eleni, Hellenthal, Garrett, Pearson, Richard, Boehnke, Michael, Seidman, Christine E., Vyse, Timothy J.   +233 more
openaire   +16 more sources

Neurocognitive, School‐Based, and Quality of Life Outcomes for Youth With Sickle Cell Disease and Thalassemia: A Scoping Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The medical burdens of sickle cell disease (SCD) and transfusion‐dependent β‐thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement.
Mary Ann Etling, Hakim Tokhi, Alexander A. Boucher   +2 more
wiley   +1 more source

The genome and sex-dependent responses to temperature in the common yellow butterfly, Eurema hecabe

BMC Biology, 2023
Background Lepidoptera (butterflies and moths) is one of the most geographically widespread insect orders in the world, and its species play important and diverse ecological and applied roles.
Ivy H. T. Lee, Wenyan Nong, Wai Lok So, Chris K. H. Cheung, Yichun Xie, Toby Baril, Ho Yin Yip, Thomas Swale, Simon K. F. Chan, Yingying Wei, Nathan Lo, Alexander Hayward, Ting Fung Chan, Hon-ming Lam, Jerome H. L. Hui   +14 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source