Results 31 to 40 of about 6,189,888 (256)

Sex-biased gene expression across mammalian organ development and evolution. [PDF]

Science, 2023
Sexually dimorphic traits are common among mammals and are specified during development through the deployment of sex-specific genetic programs. Because little is known about these programs, we investigated them using a resource of gene expression profiles in males and females throughout the development of five organs in five mammals (human, mouse, rat,
Rodríguez-Montes L, Ovchinnikova S, Yuan X, Studer T, Sarropoulos I, Anders S, Kaessmann H, Cardoso-Moreira M.   +7 more
europepmc   +3 more sources

Sex-biased gene expression at single-cell resolution: cause and consequence of sexual dimorphism. [PDF]

Evol Lett, 2023
Gene expression differences between males and females are thought to be key for the evolution of sexual dimorphism, and sex-biased genes are often used to study the molecular footprint of sex-specific selection. However, gene expression is often measured
Darolti I, Mank JE.
europepmc   +2 more sources

Sex-Biased Gene Expression and Evolution in the Cerebrum and Syrinx of Chinese Hwamei (Garrulax canorus). [PDF]

Genes (Basel), 2021
It is common that males and females display sexual dimorphisms, which usually result from sex-biased gene expression. Chinese hwamei (Garrulax canorus) is a good model for studying sex-biased gene expression because the song between the sexes is quite ...
Jiang H, Lin JQ, Sun L, Xu YC, Fang SG.
europepmc   +2 more sources

Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma. [PDF]

Am J Respir Cell Mol Biol
Abstract Asthma prevalence and severity differs between male and female individuals across the lifespan. Prepubescent boys are more likely to experience asthma, but girls are disproportionately affected after puberty, with greater symptom burden and decreased type 2 inflammation.
Kay S, Rajeevan H, Son M, Kwah J, Ramirez M, Liu Y, Wang Z, Yan X, Nino G, Britto C, Chupp G, Gomez JL.   +11 more
europepmc   +3 more sources

Widespread Adaptive Evolution of Drosophila Genes With Sex-Biased Expression [PDF]

Genetics, 2006
Abstract Many genes in higher eukaryotes show sexually dimorphic expression, and these genes tend to be among the most divergent between species. In most cases, however, it is not known whether this rapid divergence is caused by positive selection or if it is due to a relaxation of selective constraint.
Proschel, M., Zhang, Z., Parsch, J.
openaire   +6 more sources

Analysis of sex-biased gene expression in a Eurasian admixed population. [PDF]

Brief Bioinform
Abstract Sex-biased gene expression differs across human populations; however, the underlying genetic basis and molecular mechanisms remain largely unknown. Here, we explore the influence of ancestry on sex differences in the human transcriptome and its genetic effects on a Eurasian admixed population: Uyghurs living in Xinjiang (XJU ...
Cheng S, Ning Z, Huang K, Yuan Y, Tan X, Pan Y, Zhang R, Tian L, Lu Y, Wang X, Lu D, Yang Y, Guan Y, Mamatyusupu D, Xu S.   +14 more
europepmc   +3 more sources

Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes. [PDF]

BMC Pharmacol Toxicol, 2023
Abstract Background Previous pharmacovigilance studies and a retroactive review of cancer clinical trial studies identified that women were more likely to experience drug adverse events (i.e., any unintended effects of medication), and men were more likely to experience adverse events that resulted ...
Fisher JL, Clark AD, Jones EF, Lasseigne BN.   +3 more
europepmc   +4 more sources

Relationship between sex biases in gene expression and sex biases in autism and Alzheimer’s disease

, 2023
Abstract Sex differences in the brain may play an important role in sex-differential prevalence of neuropsychiatric conditions. In order to understand the transcriptional basis of sex differences, we analyzed multiple, large-scale, human postmortem brain RNA-seq datasets using both within-region and pan-regional frameworks.
Fass, Stuart B., Mulvey, Bernard, Yang, Wei, Selmanovic, Din, Chaturvedi, Sneha, Tycksen, Eric, Weiss, Lauren A., Dougherty, Joseph D.   +7 more
openaire   +2 more sources

Sex-Biased Gene Expression and Evolution of the X Chromosome in Nematodes [PDF]

Genetics, 2014
Abstract Studies of X chromosome evolution in various organisms have indicated that sex-biased genes are nonrandomly distributed between the X and autosomes. Here, to extend these studies to nematodes, we annotated and analyzed X chromosome gene content in four Caenorhabditis species and in Pristionchus pacificus.
Albritton, S., Kranz, A., Rao, P., Kramer, M., Dieterich, C., Ercan, S.   +5 more
openaire   +3 more sources

Widespread sex differences in gene expression and splicing in the adult human brain. [PDF]

, 2013
There is strong evidence to show that men and women differ in terms of neurodevelopment, neurochemistry and susceptibility to neurodegenerative and neuropsychiatric disease. The molecular basis of these differences remains unclear. Progress in this field
Ramasamy, Adaikalavan, Ryten, Mina, Ramasamy, A, Smith, C, Ryten, M, Trabzuni, D, Walker, R, Smith, Colin, Smith, C; id_orcid, Trabzuni, Daniah, Imran, S, Weale, M, Hardy, John, ?, ?, Weale, Michael E, Hardy, J, North American Brain Expression Consortium, Weale, ME, Imran, Sabaena, Walker, Robert   +19 more
core   +1 more source