Results 221 to 230 of about 180,085 (282)

Non-canonical K27 polyubiquitination is a sex-specific regulator of contextual fear memory in the hippocampus but not the amygdala. [PDF]

Behav Brain Res
Patrick MB, Kincaid SE, Arndt KC, Bae Y, Ball ON, Cummings A, Abraham JR, Bhanot G, Ray WK, Jarome TJ.   +9 more
europepmc   +1 more source

Studies on Plant Bile Pigments [PDF]

, 1979
Kufer, Werner, Scheer, Hugo
core  

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Non-canonical sex chromosome evolution revealed by extreme heterogeneity in homomorphic Y chromosome differentiation in the common frog

Carpentier F, Veltsos P, Unal E, Doucette K, Fontseré R, Brelsford A, Toups M, Perrin N, Ma W.   +8 more
europepmc   +1 more source

Differentiation of <i>Dmrt1</i> Z and W Homologs Occurred Independently in Two <i>Gekko hokouensis</i> Populations. [PDF]

Biomolecules
Senga M, Kaneko N, Matsuda Y, Matsubara K.   +3 more
europepmc   +1 more source

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Recreating viable YY^h genotype uncovers the role of CpYYL underlying YY lethality in papaya. [PDF]

Nat Commun
Yue J, Liu J, Zeng Q, Wai CM, Deng B, Tong Y, Zuo L, Xiang T, Xie W, Zhao X, Lai J, Liao J, Lai Q, Xu L, Zhu Y, He J, Zhang M, Nie S, Lin Z, Liang Y, Jiang S, Chen X, Wang B, Huang Y, Xu Y, Nguyen-Edquilang J, Ma Y, Fumia N, Jones T, Quesada-Rojas P, Mora-Newcomer E, Zhang J, Yu Q, Wang ML, Ming R.   +34 more
europepmc   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

<i>PRSSLY</i>-Based Molecular Sex Determination of Syrian Hamster (<i>Mesocricetus auratus</i>) Pups Using Placental Tissues. [PDF]

Genes (Basel)
Kumpanenko Y, Piessens L, Neven V, Dallmeier K, Alpizar YA.   +4 more
europepmc   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source