Results 231 to 240 of about 31,435,271 (262)

Haplotype-resolved genome assembly of female <i>Vernicia montana</i> elucidates its W-specific sex-determination region. [PDF]

Hortic Res
Dong X, Zhu H, Cheng J, Wu L, Zhang F, Liu Y, Tang X, Cheng X, Li W, Zhang L.   +9 more
europepmc   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Downregulation of FTO aggravates osteoarthritis with obesity by erasing m⁶A methylation of PDP2. [PDF]

Mil Med Res
Sun XY, Su JY, Chen X, Yang YX, Yang SW, Zhang CW, Li YS, Xu J, Deng ZH.   +8 more
europepmc   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Anti-HDGFL2 cryptic protein antibodies provide a sensitive readout of TDP-43 pathology and clinical disease features. [PDF]

Cell Rep Med
Citrano KJ, Maheswari Jawahar VB, Reeves MM, Petrucelli L, Carlomagno Y, Yue M, Alaiz Noya J, Daughrity LM, Baena Tomé R, Jansen-West K, Rawlinson B, DeTure M, Engelberg-Cook E, Singh A, Graff-Radford NR, Day GS, Boeve BF, Boxer AL, Knopman DS, Josephs KA, Petersen RC, Oskarsson B, Ashton NJ, Dickson DW, Gendron TF, Prudencio M, Zhang YJ, Petrucelli L.   +27 more
europepmc   +1 more source

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

Hypoxia facilitates triple-negative breast cancer stem cells enrichment and stemness maintenance through oxidized ataxia telangiectasia mutated-induced one-carbon metabolism. [PDF]

World J Stem Cells
Yang D, Ou YL, Wang SH, Jin HJ, Chen SH, Han R, Zhang H.   +6 more
europepmc   +1 more source

DMRT1 is required at two steps of ovarian differentiation in rabbits. [PDF]

Sci Adv
Dujardin E, Poulat F, Aura IB, Dewaele A, André M, McKey J, Le Gras S, Frambourg A, Jouneau L, Lupiáñez DG, Mandon-Pépin B, Pailhoux E.   +11 more
europepmc   +1 more source

Whole-Genome Resequencing Analysis Reveals Insights into Sex Determination and Gene Loci Associated with Sex Differences in <i>Procambarus clarkii</i>. [PDF]

Int J Mol Sci
Li J, Chen Y, Wang Y, Liu S.
europepmc   +1 more source

PSI/Masc-Dsx Regulatory Network in Silkworm Sex Determination Pathway. [PDF]

Insects
Tan C, Chen D, Zhang S, Dai H, Ye Y, Liu B, Lu H, Xu J.   +7 more
europepmc   +1 more source