Results 51 to 60 of about 3,446,536 (312)

Sex differences in the inflammatory response of primary astrocytes to lipopolysaccharide

Biology of Sex Differences, 2011
Background Numerous neurological and psychiatric disorders show sex differences in incidence, age of onset, symptomatology or outcome. Astrocytes, one of the glial cell types of the brain, show sex differences in number, differentiation and function ...
Santos-Galindo María, Acaz-Fonseca Estefanía, Bellini María J, Garcia-Segura Luis M   +3 more
doaj   +1 more source

Sex and age interaction in fundamental circulatory volumetric variables at peak working capacity

Biology of Sex Differences, 2022
Background Whether the fundamental hematological and cardiac variables determining cardiorespiratory fitness and their intrinsic relationships are modulated by major constitutional factors, such as sex and age remains unresolved.
Candela Diaz-Canestro, David Montero
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Alterations in vasomotor systems and mechanics of resistance-sized mesenteric arteries from SHR and WKY male rats following in vivo testosterone manipulation

Biology of Sex Differences, 2012
Background Testosterone (T) and the sympathetic nervous system each contribute to the pathology of hypertension. Altered blood vessel reactivity is also associated with the pathology of high blood pressure.
Toot Jonathan D, Reho John J, Ramirez Rolando J, Novak Jacqueline, Ely Daniel L   +4 more
doaj   +1 more source

Sex Differences in Recombination in Sticklebacks. [PDF]

, 2018
Recombination often differs markedly between males and females. Here we present the first analysis of sex-specific recombination in Gasterosteus sticklebacks. Using whole-genome sequencing of 15 crosses between G. aculeatus and G.
Cheng, Changde, Dagilis, Andrius J, Ishikawa, Asano, Kirkpatrick, Mark, Kitano, Jun, Peichel, Catherine L, Sardell, Jason M   +6 more
core   +3 more sources

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Lower variability in female students than male students at multiple timescales supports the use of sex as a biological variable in human studies

Biology of Sex Differences, 2021
Background Men have been, and still are, included in more studies than women, in large part because of the lingering belief that ovulatory cycles result in women showing too much variability to be economically viable subjects.
Benjamin L. Smarr, Annick Laure Ishami, Aaron E. Schirmer   +2 more
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Treating sex and gender differences as a continuous variable can improve precision cancer treatments

Biology of Sex Differences
Background The significant sex and gender differences that exist in cancer mechanisms, incidence, and survival, have yet to impact clinical practice.
Wei Yang, Joshua B. Rubin
doaj   +1 more source

Estrogen modulation of pain perception with a novel 17β-estradiol pretreatment regime in ovariectomized rats

Biology of Sex Differences, 2020
Estrogen plays substantial roles in pain modulation; however, studies concerning sex hormones and nociception often yield confusing results. The discrepancy could be a result of lack of consensus to regard estrogen as a variable when working with animal ...
Wenxin Zhang, Hui Wu, Qi Xu, Sheng Chen, Lihong Sun, Cuicui Jiao, Luyang Wang, Feng Fu, Ying Feng, Xiaowei Qian, Xinzhong Chen   +10 more
doaj   +1 more source