Results 41 to 50 of about 98,247 (293)

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

COMMITMENT DURING NEMATOCYTE DIFFERENTIATION IN HYDRA [PDF]

, 1981
Nematocytes in Hydra differentiate from interstitial stem cells. Desmonemes differentiate mainly in the distal half of the body column while stenoteles differentiate predominantly in the proximal half.
Fujisawa, Toshitaka, David, Charles N.
core  

Disorders of Sexual Differentiation

, 2007
The establishment of chromosomal sex (46,XY or 46,XX) is considered the first step in normal sexual differentiation. However, the first sexual structures that form may be considered as either primordial or neutral.
Berkovitz, Gary
core   +1 more source

Male or female? Brains are intersex

Frontiers in Integrative Neuroscience, 2011
The underlying assumption in popular and scientific publications on sex differences in the brain is that human brains can take one of two forms male or female, and that the differences between these two forms underlie differences between men and women in
Daphna eJoel
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits

, 2002
We tested the hypothesis that genes encoded on the sex chromosomes play a direct role in sexual differentiation of brain and behavior. We used mice in which the testis-determining gene (Sry) was moved from the Y chromosome to an autosome (by deletion of ...
Robin Lovell-Badge, De Vries, Geert, Auger, CJ, Lovell-Badge, R, Catherine J. Auger, Elka M. Scordalakes, Swain, A, Simerly, Richard B., Lovell-Badge, Robin, Richard B. Simerly, Amanda Swain, Arnold, Arthur P., Simerly, RB, Burgoyne, PS, Scordalakes, Elka M., Emilie F. Rissman, Geert J. De Vries, Liang-Yo Yang, Burgoyne, Paul S., Yang, Liang-Yo, Yang, L-Y, Rissman, EF, Rissman, Emilie F., Paul S. Burgoyne, De Vries, G, Arnold, AP, Arthur P. Arnold, Scordalakes, EM, Swain, Amanda, Auger, Catherine J.   +29 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A genome-wide association study of female sexual dysfunction.

, 2012
PMCID: PMC3324410. CCBurri LC et al.PLOS Genet Doi:10.1371/journal.pone.0035041Female sexual dysfunction (FSD) is an important but controversial problem with serious negative impact on women's quality of life.
Spector Tim D., Rahman Qazi, Rahman, Qazi; id_orcid, Tim D Spector, Qazi Rahman, Clop Alex, Burri Andrea, Spector, Tim D., Pirro Hysi, Alex Clop, Burri, A, Rahman, Q, Spector, TD, Hysi, Pirro, Hysi Pirro, Hysi, P, Clop, Alex, Burri, Andrea, Andrea Burri, Clop, A   +19 more
core   +1 more source

ENDOCRINAL DISORDERS: ETIOLOGY AND PATHOGENESIS. DYSFUNCTIONS OF THE SEXUAL GLANDS

Вопросы современной педиатрии, 2012
The issues of etiology, pathogenesis, clinical manifestations and development mechanisms of the most common forms of endocrinalregulation of the sexual glands, impairments of the puberty in girls and boys and sexual dysfunction in women and men are ...
P. F. Litvitskii
doaj   +1 more source